tbh-1

Tyramine beta-hydroxylase

657 amino acids

Required for the conversion of tyramine to octopamine, a precursor of octapamine but probably itself a neurotransmitter (PubMed:15848803). Involved in the regulation of egg laying, which is inhibited by tyramine (PubMed:15848803). Due to its involvement in octopamine biosynthesis, also required for crtc-1-dependent regulation of AMPK-mediated longevity (PubMed:25723162).

Belongs to the copper type II ascorbate-dependent monooxygenase family.

74.963 kDa

MEPTASQGIQYLRGGVEWILKLLNLHILNVKHENKPLLFRLIDLKVYIPSSVSTVRWSSGASSYVILGEYRKMRSAVALLFLLVAYCGGVVHAGEIVAELYHTNVTVKWHTDYERQLVDFSIWFGASTPDVLFLGFSDFGDTNNSDVLMYYNSKKEIKDAYTNRDFKITSDLQQDFQLLRKRKDHIVVRRKLTTCDSRDYAFLPGTTQFYIAASWGSTNLVDIRDKRWVVDKKFGKVIEGPTDQPNIEEEPAALEKDVKVVIVNSNSPDPIPNVETTYKCIIRKMPFDTVNNMYHVVRMEPYVTPGNEHLVHHMEIFMCRDEVEEWSGSCNDPKKPPKSKSCSHVIAAWAMGEGPIHYPKEAGLPIGGKGKNAYVMVEIHYNNPELHKGVIDSSGFQFFVTGQLRKYDAGIMELGLIYSDANSVPPNQKAWAMNGYCPSQCTKNLPEEGINIFASQLHAHLTGRKLFTSQYRSGVRIGDVNRDEHYSPHWQHLQQLRPVVKVMPGDTLVTTCVYDTRKRSKVTFGGYRIVDEMCVNYIYYYPASDVEVCKSAISNSTLRAYFSERHGMDGKRMQISDMYSNVKDWGNGVDEEFYNVLNVGNMNMNCLKSNGEPFEFESKDSRQSWENMARPTFVSGSFITTRDRFQCPAINDMINFE

tbh-1

Tyramine beta-hydroxylase

585 amino acids

Converts tyramine into octopamine, a neurotransmitter involved in pharyngeal pumping and egg laying.

Belongs to the copper type II ascorbate-dependent monooxygenase family.

67.137 kDa

MKCANAAALLFFVLCDIGVHGGEIVAELLHSNVTVKWQTDYERQTVDFSIWFGAKTPDLLFLGFSDFGDMNSSDVLMYDNVKREIMDSYTNRDYKIIPDLSQDFQQLRRRKDHFVVRRKLTTCDSRDYAFQRGTTQFYIAASFGYRNLVDIRDKKWILDKKFGKVIEGPTDQPSTDEGVSSLERDVQLVIVNSNSPDPVPNVETTYECIIRKMPFDTVHKTYHIVRMEPYITPGNEHLVHHMEVFLCRDEVEEWSGNCNDPKKPKKSKSCSHVIAAWAMGEGPIHYPREAGLPIGGKGKNEYVMVEIHYNNPELHKGVMDTSGFQFYVTGLLRIYDAGIMELGLIYSDANSVPPNQKAWAMNGYCPSQCTQNLPEEGINIFASQMHAHLTGRKLWTSQYRDGVQIGDVNRDEHYSPHWQHLQQLRPMVRVMPGDTLVTTCVYDTRRRSNVTFGGYGITDEMCVNYIYYYPASEVEVCKSAISNSTLRAYFSQRHGMDGKTMKISDMYNGVKDWSNGVDEEFYNVLNVGNVNMNCLKSNGESFEFKSKDPRQGWENMARPRLFSGSFIRTRDRFQCPAINDMINFE