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tal-3A

Gene
tal-3A
Protein
Peptide tarsal-less 3A
Organism
Drosophila melanogaster
Length
11 amino acids
Function
One of four peptides (tal-1A, tal-2A, tal-3A and tal-AA) produced from a polycistronic gene that function redundantly in several developmental processes (PubMed:17439302, PubMed:17486114, PubMed:25344753, PubMed:21527259). Required in early stages of leg development for the intercalation of the tarsal segments during the mid-third instar stage and later for tarsal joint formation (PubMed:17439302, PubMed:18801356, PubMed:21527259). Promotes the post-translational modification of ovo isoform B (svb) into its active form which in turn initiates trichome development and promotes tarsal joint development (PubMed:21527259, PubMed:20647469, PubMed:26383956). This is likely due to recruitment of the E3 ubiquitin-protein ligase Ubr3 to svb for ubiquitination of its N-terminus, converting svb into a transcriptional activator (PubMed:26383956). Also enhances interaction of Ubr3 with Diap1 (PubMed:26383956). Required for correct wing and leg formation through its regulation of several genes including those in the Notch signaling pathway (PubMed:18801356, PubMed:21527259, PubMed:21682860). Essential for denticle formation and may have a role in the developmental timing of trichome differentiation (PubMed:17486114, PubMed:25344753). Essential for the development of taenidial folds in the trachea (PubMed:17486114).
Mass
1.236 kDa
Sequence
MSHDLDPTGTY