Protein
5'/3'-nucleotidase SurE
Organism
Photorhabdus luminescens subsp. laumondii (strain DSM 15139 / CIP 105565 / TT01)
Function
Nucleotidase with a broad substrate specificity as it can dephosphorylate various ribo- and deoxyribonucleoside 5'-monophosphates and ribonucleoside 3'-monophosphates with highest affinity to 3'-AMP. Also hydrolyzes polyphosphate (exopolyphosphatase activity) with the preference for short-chain-length substrates (P20-25). Might be involved in the regulation of dNTP and NTP pools, and in the turnover of 3'-mononucleotides produced by numerous intracellular RNases (T1, T2, and F) during the degradation of various RNAs.
Similarity
Belongs to the SurE nucleotidase family.
Sequence
MLRILLSNDDGVTAPGIQVLAAALRENYHVQVVAPDRNRSGASNALTLDRSLSVNTLENGDISVLGGTPTDCVYLGVNRLVLPRPEIVVSGINRGPNLGDDVIYSGTVAAAMEGRHLGLPALAISLNGELHYQTAAEITCRLLQMLQTTPLRAGNILNVNVPDLPLEHIKGFRVTRCGSRHAAEEVYSMQDPKGNMLYWLGPPGDKHDAGPETDFAAVEQGYVSITPLQVDLTAYKAQALVRDWLAKAEVDGEC