STIL

SCL-interrupting locus protein

1287 amino acids

Immediate-early gene. Plays an important role in embryonic development as well as in cellular growth and proliferation; its long-term silencing affects cell survival and cell cycle distribution as well as decreases CDK1 activity correlated with reduced phosphorylation of CDK1. Plays a role as a positive regulator of the sonic hedgehog pathway, acting downstream of PTCH1 (PubMed:16024801, PubMed:9372240). Plays an important role in the regulation of centriole duplication. Required for the onset of procentriole formation and proper mitotic progression. During procentriole formation, is essential for the correct loading of SASS6 and CENPJ to the base of the procentriole to initiate procentriole assembly (PubMed:22020124).

142.955 kDa

MEPIYPFARPQMNTRFPSSRMVPFHFPPSKCALWNPTPTGDFIYLHLSYYRNPKLVVTEKTIRLAYRHAKQNKKNSSCFLLGSLTADEDEEGVTLTVDRFDPGREVPECLEITPTASLPGDFLIPCKVHTQELCSREMIVHSVDDFSSALKALQCHICSKDSLDCGKLLSLRVHITSRESLDSVEFDLHWAAVTLANNFKCTPVKPIPIIPTALARNLSSNLNISQVQGTYKYGYLTMDETRKLLLLLESDPKVYSLPLVGIWLSGITHIYSPQVWACCLRYIFNSSVQERVFSESGNFIIVLYSMTHKEPEFYECFPCDGKIPDFRFQLLTSKETLHLFKNVEPPDKNPIRCELSAESQNAETEFFSKASKNFSIKRSSQKLSSGKMPIHDHDSGVEDEDFSPRPIPSPHPVSQKISKIQPSVPELSLVLDGNFIESNPLPTPLEMVNNENPPLINHLEHLKPLQPQLYDEKHSPEVEAGEPSLRGIPNQLNQDKPALLRHCKVRQPPAYKKGNPHTRNSIKPSSHNGPSHDIFEKLQTVSAGNVQNEEYPIRPSTLNSRQSSLAPQSQPHDFVFSPHNSGRPMELQIPTPPLPSYCSTNVCRCCQHHSHIQYSPLNSWQGANTVGSIQDVQSEALQKHSLFHPSGCPALYCNAFCSSSSPIALRPQGDMGSCSPHSNIEPSPVARPPSHMDLCNPQPCTVCMHTPKTESDNGMMGLSPDAYRFLTEQDRQLRLLQAQIQRLLEAQSLMPCSPKTTAVEDTVQAGRQMELVSVEAQSSPGLHMRKGVSIAVSTGASLFWNAAGEDQEPDSQMKQDDTKISSEDMNFSVDINNEVTSLPGSASSLKAVDIPSFEESNIAVEEEFNQPLSVSNSSLVVRKEPDVPVFFPSGQLAESVSMCLQTGPTGGASNNSETSEEPKIEHVMQPLLHQPSDNQKIYQDLLGQVNHLLNSSSKETEQPSTKAVIISHECTRTQNVYHTKKKTHHSRLVDKDCVLNATLKQLRSLGVKIDSPTKVKKNAHNVDHASVLACISPEAVISGLNCMSFANVGMSGLSPNGVDLSMEANAIALKYLNENQLSQLSVTRSNQNNCDPFSLLHINTDRSTVGLSLISPNNMSFATKKYMKRYGLLQSSDNSEDEEEPPDNADSKSEYLLNQNLRSIPEQLGGQKEPSKNDHEIINCSNCESVGTNADTPVLRNITNEVLQTKAKQQLTEKPAFLVKNLKPSPAVNLRTGKAEFTQHPEKENEGDITIFPESLQPSETLKQMNSMNSVGTFLDVKRLRQLPKLF

stil

SCL-interrupting locus protein homolog

1281 amino acids

Plays an essential role in early embryonic development. Plays an important role in the regulation of centriole duplication.

140.986 kDa

MSTSINLKNTQFYKEVRGVSMENQRNLRSMSNRMLSVNFPPSKCALWDPAPMGDPFGLHFSYYRNPRLLVSEKALRLSSRHAKTGRKPFSCFLLGTFSVDEDEEGVTLTVDRFDPGREKTGSGSSKVPTAQLPGDFIIPCTISIGKGSNNVIVHTPEDFTSSFMSLQSHLHGKEALDLAKLLAMRAHITYTENMDNLHFDLHWAAVTVANTFESTPIKPVPIIPTALARNLGSHNNIAHLQGTHKSGYLTMDQTRKLLLVLESDPKVYMLPLVGIWLSGITHIHSPQVWAACLRYIFSSSIHERVLSESGSFLIILYSLTHKEPEFYECSPCVKHDPLGFQLLTCQDTLHLFKNAEVSKNPLLRFELSSECQELEADLFNETCKNKSTTVFKQSPLPNKLSTSDHDSGVEEEDFSPRPSPRPHPSVQQVSRIHPSVPELSLVFSSFFDPKSASHNPENRTRNNSPFSSTPQNVNNMFAGAPKPNKEPQPCDNQASGLLPRPAPSLNTNSTAMKPSKVKSSPADYQPPHLQSSNQIRRNSTSTSSAFSTPRSGCSPDSTVHQVKGSCEQEQNINGSAQPQGTTPLMRSGSYSRQVSSNFPNHNVTFPLHSRHVAEVAKPSPNLAPFHQTNVCTSCHSLVSCHSKNCWPAMGHLTYHTMENPPETCESVMPAYQNVVCPSVCCPQTAGKTEFCSPVDLVLLSPGRRDSLPLNPCSPHTCRHTPPPVIPTATGMLGLSTEAYRLFAEQDKQLKLLQAQIQRLLEAQAAESEPSKTTIPNNSKQKQVESVSTEQEIKTSVSIAVSTGASLFWNPPCPEKEESMDKQDDSAFCNEFSVNVNTEDTSHATITSSIRAVDIHSFSESTQLTDRGNCTASLHVSHERDDASYPLPDVQQDINNSKSLSNQTDHTESPNTAEIDSGVSAVPPEKFYQDLLAQVNNLLKTSSTEDEMTSTKIDSGHIIEKTESLPCNPTENNDKNVLKATLKQLKSLGVNIDMNTSELQATKADTADSASILACINPEAVIPRLNYMSFSNIGLSGFVPNGVDLSMEANAIALKYLNESQLNQLSLSHANKNKQSDSISYNSLLPGTTEKSMVGLSLISPSNMSFATKKYMKRYGLIESSDSSMEEPDLANASSFALTPMSSDSTSENRLFFNDSCKDGNFVTCEEQKRKNADVDSAIGWAHHPETNKLRNITNEISGKLINVAPLQEDRPLHFLKDLKARTKLSAGKAQFTQHPEKENTGDVQFFHEKHDGFSGKKSLGGPSTVGDILDVNRLRQLPKLF

stil

SCL-interrupting locus protein homolog

1263 amino acids

Plays an essential role in early embryonic development (PubMed:12006978). Plays an important role in the regulation of centriole duplication (By similarity).

138.246 kDa

MNRVQVDFKGLPAHILENSIAAESLQNTRSSDNVLTPLTFPKSKVALWDPSANGEVVSLHFSYYRNPRLFLVEKALRLAHRHARQTNKPRFFCFLLGTLAVDSDEEGVTITLDRFDPGREQTGCLGKAPTALLPGDILVPCVFEAQHAASSTVHSSEDLNISFKMLQHFCCSKELLELSKLLTLRAQLSCSENMDRLTFNLSWAAVTLACTLDAVPIRAVPIIPTALARNLSSPAGVTQNSKRGFLTMDQTRKLLLILESDPKAYTLPLVGIWLSGVTHIHNPLVWAWCLRYLHSSSLQDKVLSEGGTFLVVLYSLTHRDPEFYQCKPSTGQQQLSFQLLTSRDSLTLYKNVEPSEGRPLQFELSSENQNQETVLFEEVLSQSVLTGTTLGAASAAPQNKLSISDHDSGVEDEDLSPRPSPNPHPVSQQTKRVHPLVPELSMVLDGSFLDGSVVNTQGSTPLSHSQSNVHRRNSSPALQGLSVLRPLVQGSVTKPPPIRRPLTPILSQPKNKLHPNPSQQTPQHSVSRKSLPSMRRSREGSSASSVSSSSSSSSTKNASPNGSFHQQRQRLSQGFPNKPQLIYSGPPTSGHSSAKKSSSVPSQTPVPHPSQHRIFHSTPAVNPCNCCTNHPSVAPLYQNNTWQGTPGYPTAVHSPCVFHCSPETVPPGDHCLSPSRQSLGCRVSPTKSPVCYHSTPPHYSPSSGPCVPTIISNKGLVEQTPSCQAQCCQVKGSKEPCLDTPMGLLPADAYRMLIDQERQLKLLQLQIQKLLESQSKVPEVSSEQNAQQQRPNQVPASPPKRTSVSIAVGTGASLFWSTPQETSTHEASSLEWQTETEPKSGCQNDSTVTSRDRSESACHYSEEHCPGSPQHPTSPQHNTSSGFGVQMFQSPVLGESASMYYQSQSQSKDLSENREIDDPRFYHELLGQVQSRLQDSVIVEDKVEQDQQSLLKTQSLSPVVHQSRKPLTTSSIPQTQKTKQPSSPPNQDRVLSATLKQLQQFGVNIDLDSSQEKTTRATVESASTLACINPEAVIPRLALSEPVGASIWGPSGSVDLSLEANAIALKYLSDSQLSRLSLGSQSSSPHSDPSTILLRRPAVEKSNVALSILSPSNMSLATCKYMKKYGLIEGEISSEEEQEDPIQVDSALGCSVQHETSKTISLGQEREEQNTAVLKNITNKPVVNLHTSPIDSQEQILQDLRPKMQLLLRGGTNSEKENATKRNLIERRSSLTENQRTQEVVDPQGSVGNFLDLSRLRQLPKLF

Stil

SCL-interrupting locus protein homolog

1262 amino acids

Immediate-early gene. Plays an important role in embryonic development as well as in cellular growth and proliferation; its long-term silencing affects cell survival and cell cycle distribution as well as decreases CDK1 activity correlated with reduced phosphorylation of CDK1. Plays a role as a positive regulator of the sonic hedgehog pathway, acting downstream of PTCH1. Plays an important role in the regulation of centriole duplication. Required for the onset of procentriole formation and proper mitotic progression. During procentriole formation, is essential for the correct loading of SASS6 and CENPJ to the base of the procentriole to initiate procentriole assembly (By similarity).

138.757 kDa

MNTRFPSSKMVPFHFPPSKLALWNPMPIGECIYLHLSYYRKPKLMVTEKAIRLAYRHAKQNKKNVPCFLLGSLTVDEDEEGVTLTIDRFDPGREIPECLERTPTASLPGDFLIPCRVHIQGLGSRDVIVHNADDFSSALKALQYHVCSKDFLDCGKLLCLRAQITPRESLDGVDFNLQWTAVTLANSFKCVPVKPIPIIPTALARNLSSNLNISQVQGTYKHGYITMDETRKLLLLLQSDPKVSSLPLVGIWLAGIIHVYSPQVWACCLRYMFSSSIQERVFSESGNFIIVLYSLTHKEPEFYECLPCESRTPDLQFQLLTNKETLHLFNNVEPSGKNPIHFELSAESQDAEAEAEVLSKISKTLPVKRSSQKVSPGKIPINKHDTDLEDEDFSPRPIPSPHPVSQKISKVQPSVPELSLVLDNNFTESSNQSNPLEMMTVENPLLIKPSQPELCDAKHSSEATTGEPFRRGPTNQLSQDTALRQSRGKQSSTCKKESLQFRNTNAKPSLSVPSPDVAEKLQAVSAGSMQKEDYPVRPSTLDSRQPSLAPQAQPHNLVFSTHNSTRPMELQVPTPSLPSYYPTNVCSCCQHHGHIQYSTINSWQGNTVGSIQDLRSESLPKHAFFHSSGCPSLCPNAIYSSSSPVSMKQGGMGAYSPHSNGEPSPVAGPSHVDSCVPHPCAMCMHTPNTAPDNGMMGLSPDAYRFVTEQDRQLRLLQAQIQRLLEAQSLDPGSHKTVATMEDTVKAARQMELVSMEAQSSPGLHMRKSVSIAVSTGASLFWNAAGDDQEPDSQPKQDDTKISSEDMNFSVDINNEATSLPGSASSLKAVDIPSFEESNLAVEEVNQPLPESNSSSEQSKEPGVPVFFPNALLAESVSMCLQTAPTEGASNSTELPQGTKDEPYRPSDNQKIYQDLLGQVNHLLSNASQETEEPPTKAVVTNHECAKTQNTHHARKKRHNSGLVDKDCVLSATIKQLRSLGVKIDSPTKVKKNEQKVDHASVLACISPEAVISGLNYMSFGNVGMSSLSPTGVDLSMEANAIALKYLSENQLSQLSLARSKQNNGDSSVGLLHINSDRSTVGLSLVSPSNMSFATKKYMKRYGLLQSSDNSEDEEEPPSHADSESDHVLNRNPACRPVQCGHEKEPSWNACEIAQCSDCGSADTRTDVPVLRNITNQAVQPRATEHLNEDSAISLRNLKPNPAMNLRTGKAEFTHHPEKENERDIAVFPGTLPSPETLKQMNSMDSVGTFLDVKRLRQLPKLF

stil

Protein stand still

321 amino acids

Essential in the female germline for proper survival, sex determination and differentiation. Participates in the transcriptional activation of Otu. Does not regulate the expression of Ovo.

35.776 kDa

MSVNLDGSEEKMELKKHVPYILNGELYRIEKQVGDNVTVKCCYCPPDRIYRGSVRSTGNFHMHIKRRHSSLLGKLHEMKVAALEERRDRIMKNRRFAKSRKKAPVAVAATSTAAQSDSGVFVDMQAAVPSGNESHELKIKTVFQRHKQEQEGATRKLEDSTSDKANLPNIPKNLGIVVQNVSNISVETLPGGSTPASVSFLGRPVKPEQGSGPSFLADQPAAIDLSQVPPVQGESKSSGSLASSMEDVSMEYSRSQALSQSLSMAHFLEHPQRDVLQRLERSMAQISQELHCRNRIEHNRMLLEAAKFKFLNPNFQFEPNL