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stard3

Gene
stard3
Protein
StAR-related lipid transfer protein 3
Organism
Danio rerio
Length
448 amino acids
Function
Sterol-binding protein that mediates cholesterol transport from the endoplasmic reticulum to endosomes. Creates contact site between the endoplasmic reticulum and late endosomes: localizes to late endosome membranes and contacts the endoplasmic reticulum. Acts as a lipid transfer protein that redirects sterol to the endosome at the expense of the cell membrane and favors membrane formation inside endosomes.
Similarity
Belongs to the STARD3 family.
Mass
50.751 kDa
Sequence
MPSAVDYSELGGSLPAIASLNASYSQASLSLPSPYYCPLPPGERKAFSDVRRTFCLFVTFDLLFITLLWIIELNISKSIWNSLENEVVHYNFKSSFFDIFLLAVFRFLCLQLGYAAFRLRHWWVIAITTLVTTAFLIAKVILSDLFSQNAFGYVLPITSFVVAWLETWFLDFKVLTQEAEDERVYLAAVNAACEPAPLICPRPVSDGQFYSPPESLAGSEDDLDEEGLGRRAVTEQEKAFVRQGREAMAVVEQILTQEENWKFEKTNELGDAVYTLEIPFHGKTFILKGLLQCTAELVYQEVILQPEKMVQWNRTVSVCQILQRVDDNTMVSYDVSAGAAGGVVSPRDFVNVRRVERRRDCYISAGMATNHNSKPHHSRYVRGENGPGGFVVLKSSSNPSVCTFIWVLNTDLKGRLPRYLIHQSLAATMFEFMSHLRQRINEVHVSYR

Gene
Stard3
Protein
StAR-related lipid transfer protein 3
Organism
Mus musculus
Length
446 amino acids
Function
Sterol-binding protein that mediates cholesterol transport from the endoplasmic reticulum to endosomes (By similarity). Creates contact site between the endoplasmic reticulum and late endosomes: localizes to late endosome membranes and contacts the endoplasmic reticulum via interaction with VAPA and VAPB (By similarity). Acts as a lipid transfer protein that redirects sterol to the endosome at the expense of the cell membrane and favors membrane formation inside endosomes (By similarity). May also mediate cholesterol transport between other membranes, such as mitochondria membrane or cell membrane (By similarity). However, such results need additional experimental evidences; probably mainly mediates cholesterol transport from the endoplasmic reticulum to endosomes (By similarity). Does not activate transcriptional cholesterol sensing (By similarity).
Similarity
Belongs to the STARD3 family.
Mass
50.47 kDa
Sequence
MSKRPGDLACDLERSLPALASLGTSLSHSQSLSSHFIPPPLEKRRAISDVRRTFCLFVTFDLLFISLLWIIELNTNTGIRKNLEQEVIHYSFQSSFFDIFVLAFFRFSGLLLGYAVLRLQHWWVIAVTTLVSSAFLIVKVILSELLSKGAFGYLLPIVSFVLAWLETWFLDFKVLPQEAEEERWYLAAQAAVARGPLLFSGALSEGQFYSPPESFAGSDNESDEEVTGKKSFSAQEREYIRQGKEATAVVDQILAQEENWKFERSNEYGDTVYTIEVPFHGKTFILKTFLPCPAELVYQEVILQPERMVLWNKTVTACQILQRVEDNTLVSYDVSSGAAGGVVSPRDFVNVRRIERRRDRYLSSGIATTHCSKPPTHKYVRGENGPGGFIVLKSANNPRVCTFVWILNTDLKGRLPRYLIHQSLGATMFEFAFHLRQRVGELGARA

Gene
STARD3
Protein
StAR-related lipid transfer protein 3
Organism
Homo sapiens
Length
445 amino acids
Function
Sterol-binding protein that mediates cholesterol transport from the endoplasmic reticulum to endosomes (PubMed:11053434, PubMed:15930133, PubMed:22514632, PubMed:28377464). Creates contact site between the endoplasmic reticulum and late endosomes: localizes to late endosome membranes and contacts the endoplasmic reticulum via interaction with VAPA and VAPB (PubMed:24105263, PubMed:28377464). Acts as a lipid transfer protein that redirects sterol to the endosome at the expense of the cell membrane and favors membrane formation inside endosomes (PubMed:28377464). May also mediate cholesterol transport between other membranes, such as mitochondria membrane or cell membrane (PubMed:12070139, PubMed:19965586). However, such results need additional experimental evidences; probably mainly mediates cholesterol transport from the endoplasmic reticulum to endosomes (PubMed:28377464). Does not activate transcriptional cholesterol sensing (PubMed:28377464). Able to bind other lipids, such as lutein, a xanthophyll carotenoids that form the macular pigment of the retina (PubMed:21322544).
Similarity
Belongs to the STARD3 family.
Mass
50.502 kDa
Sequence
MSKLPRELTRDLERSLPAVASLGSSLSHSQSLSSHLLPPPEKRRAISDVRRTFCLFVTFDLLFISLLWIIELNTNTGIRKNLEQEIIQYNFKTSFFDIFVLAFFRFSGLLLGYAVLRLRHWWVIAVTTLVSSAFLIVKVILSELLSKGAFGYLLPIVSFVLAWLETWFLDFKVLPQEAEEERWYLAAQVAVARGPLLFSGALSEGQFYSPPESFAGSDNESDEEVAGKKSFSAQEREYIRQGKEATAVVDQILAQEENWKFEKNNEYGDTVYTIEVPFHGKTFILKTFLPCPAELVYQEVILQPERMVLWNKTVTACQILQRVEDNTLISYDVSAGAAGGVVSPRDFVNVRRIERRRDRYLSSGIATSHSAKPPTHKYVRGENGPGGFIVLKSASNPRVCTFVWILNTDLKGRLPRYLIHQSLAATMFEFAFHLRQRISELGARA

Gene
STARD3
Protein
StAR-related lipid transfer protein 3
Organism
Macaca mulatta
Length
445 amino acids
Function
Sterol-binding protein that mediates cholesterol transport from the endoplasmic reticulum to endosomes (By similarity). Creates contact site between the endoplasmic reticulum and late endosomes: localizes to late endosome membranes and contacts the endoplasmic reticulum via interaction with VAPA and VAPB (By similarity). Acts as a lipid transfer protein that redirects sterol to the endosome at the expense of the cell membrane and favors membrane formation inside endosomes (By similarity). May also mediate cholesterol transport between other membranes, such as mitochondria membrane or cell membrane (By similarity). However, such results need additional experimental evidences; probably mainly mediates cholesterol transport from the endoplasmic reticulum to endosomes (By similarity). Does not activate transcriptional cholesterol sensing (By similarity). Able to bind other lipids, such as lutein, a xanthophyll carotenoids that form the macular pigment of the retina (PubMed:21322544).
Similarity
Belongs to the STARD3 family.
Mass
50.229 kDa
Sequence
MSKLPGELARDLECSLPAVASLGSSLSHSQSLSSHLLPPPEKRRAISDVRRTFCLFVTFDLLFISLLWIIELNTNTGIRKNLEQEIIQYNFKTSFFDIFVLAFFRFSGLLLGYAVLRLQHWWVIAVTTLVSSAFLIVKVILSELLSKGAFGYLLPIVSFVLAWLETWFLDFKVLPQEAEEERWYLAAQAAVARGPLLFSGALSEGQFYSPPESFAGSDNESDEEVAGKKSFSAQEREYIRQGKEATAVVDQILAQEENWKFEKNNEYGDTVYTIEVPFHGKTFILKTFLPCPAELVYQEVILQPERMVLWNKTVTACQILQRVEDNTLISYDVSAGAAGGMVSPRDFVNVRRIERRRDRYLSSGIATAHSAKPLTHKYVRGENGPGGFVVLKSASNPCVCTFVWILNTDLKGRLPRYLIHQSLAATMFEFAFHLRQRISELGARA

Gene
stard3
Protein
StAR-related lipid transfer protein 3
Organism
Salvelinus fontinalis
Length
294 amino acids
Function
Sterol-binding protein that mediates cholesterol transport from the endoplasmic reticulum to endosomes. Creates contact site between the endoplasmic reticulum and late endosomes: localizes to late endosome membranes and contacts the endoplasmic reticulum. Acts as a lipid transfer protein that redirects sterol to the endosome at the expense of the cell membrane and favors membrane formation inside endosomes.
Similarity
Belongs to the STARD3 family.
Mass
32.807 kDa
Fragment
single
Sequence
DGYICNNGMDKEERKMCGLLLLPLRSVSPSAYLAAVNAASERAPMIYPRAVSEGQFYSPPESLAGSEEDLDEEGLGRRAVSPQEKALVRQGKEAMAVVEQILAQEENWKFEKNNDVGDSVYTLEIPFHGKTFILKAFMQCPAELVYQEVILQPEKMAQWNKTVSGCQILQRVDDNTLVSYDIASGAAGGVVSARDFVNVRRVERKRDCYVSAGMATDHDGKPPHSRYVRGENGPGGFVVLKSSSNPSVCTFIWVLNTDLKGRLPRYLIHQSLAATMFEFMAHLRQRIRDLRSTR