Protein
Afadin- and alpha-actinin-binding protein A
Function
Belongs to an adhesion system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). Involved in cell movement (By similarity). Acts as a centrosome maturation factor, probably by maintaining the integrity of the pericentriolar material and proper microtubule nucleation at mitotic spindle poles. The function seems to implicate at least in part WRAP73; the SSX2IP:WRAP73 complex is proposed to act as regulator of spindle anchoring at the mitotic centrosome.
Similarity
Belongs to the ADIP family.
Sequence
MGDRRTISLPESDKILQYCSEIRMSPTSLLPSPSHSVANNLSGSVYTFCTEDNLEQCITYIDQELRTIGFPTVQAVSKNGEGRKLHLVSIINCIYELLQRNSQTMRSNEEVETQLLKINGDLEYLQSIHQRQKDQLEATKRENCALQERDRQMQCKNRNLLQLLKNEKEEVQKLQNIIASRSTQYNHSVKRKEREYNKLKERLYQLVMDKRDKKISIDVLNYVGRADGKRSSWRTGKTDAKNEEEMYKVLLNDYEQRQKQLMVENVELKKVLQQMKKEMISIVSQRKTKEKLEDSTGTVTSDIEEEIADSSKENLSELSCEAVREQLISSIRQQWRILKSHMEKLDNQACLVNVPTPDENGLIARAEHEQELDKLISEIQQCKETIRSQQQLLKQQLSVPRDDDTSKLLQDCYLLEDKERLQEEWKLFNAQKKNFEKERRNFTEAAIRLGHEKKVFEEDRAAWLKHQFLNMTVFSDHKNLEERKVPGVHFSSEQDNCRLHSRPHDKVLASSGDYSRRPSKALPITSSSKHSLTQIESISWRDSSISPNDTDFLN