Protein
RNA polymerase II subunit A C-terminal domain phosphatase ssu-72
Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Function
Component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. Ssu-72 is required for 3'-end formation of snoRNAs (By similarity).
Similarity
Belongs to the SSU72 phosphatase family.
Sequence
MSAVDTPTGAASSSKPDQNEQNGQNGGREDSGGFKLKFCTVCASNQNRSMEGHLRLSLANYPVISFGTGSLVRLPGPSITQPNVYKFNETSYDSIYRELEAKDPRLYRANGLLNMLGRNRQVKWGPERWQDWQIGMPRTKHKDDKGADGMEGGVADVVITCEERCWDAVIEDLLNRGSPLNRPVHVINIDIKDNHEEASVGGRAIVDLADSLNKIAAEEREKVGASAFDSGSVGARSGFDERVPDVLAEWQERWPNLPATWTLAWF