sspH1

E3 ubiquitin-protein ligase SspH1

700 amino acids

Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein is an E3 ubiquitin-protein ligase that interferes with the host's ubiquitination pathway and targets host proteins for proteasomal degradation. Can ubiquitinate ubiquitin, giving rise to polyubiquitin chains (in vitro). Polyubiquitinates host PKN1, leading to its proteasomal degradation. Down-modulates production of host proinflammatory cytokines by inhibiting NF-kappa-B-dependent gene expression; this depends only partially on its E3 ubiquitin-protein ligase activity.

Belongs to the LRR-containing bacterial E3 ligase family.

77.119 kDa

MFNIRNTQPSVSMQAIAGAAAPEASPEEIVWEKIQVFFPQENYEEAQQCLAELCHPARGMLPDHISSQFARLKALTFPAWEENIQCNRDGINQFCILDAGSKEILSITLDDAGNYTVNCQGYSEAHDFIMDTEPGEECTEFAEGASGTSLRPATTVSQKAAEYDAVWSKWERDAPAGESPGRAAVVQEMRDCLNNGNPVLNVGASGLTTLPDRLPPHITTLVIPDNNLTSLPELPEGLRELEVSGNLQLTSLPSLPQGLQKLWAYNNWLASLPTLPPGLGDLAVSNNQLTSLPEMPPALRELRVSGNNLTSLPALPSGLQKLWAYNNRLTSLPEMSPGLQELDVSHNQLTRLPQSLTGLSSAARVYLDGNPLSVRTLQALRDIIGHSGIRIHFDMAGPSVPREARALHLAVADWLTSAREGEAAQADRWQAFGLEDNAAAFSLVLDRLRETENFKKDAGFKAQISSWLTQLAEDAALRAKTFAMATEATSTCEDRVTHALHQMNNVQLVHNAEKGEYDNNLQGLVSTGREMFRLATLEQIAREKAGTLALVDDVEVYLAFQNKLKESLELTSVTSEMRFFDVSGVTVSDLQAAELQVKTAENSGFSKWILQWGPLHSVLERKVPERFNALREKQISDYEDTYRKLYDEVLKSSGLVDDTDAERTIGVSAMDSAKKEFLDGLRALVDEVLGSYLTARWRLN

sspH1

Small, acid-soluble spore protein H 1

65 amino acids

Belongs to the SspH family.

6.947 kDa

MDASRASQLINSKASYVYCKGKPVIIKSVDESSKMATVQSVDNGATMIAPLNDIRESGVINNQNS

sspH1

Small, acid-soluble spore protein H 1

62 amino acids

Belongs to the SspH family.

6.858 kDa

MDASRASQLINSRETDVYCKSEPVIIRSVDEYSKMATVESLNNGTTIMAPLNDIRDSGVINH

sspH1

Small, acid-soluble spore protein H 1

62 amino acids

Belongs to the SspH family.

6.858 kDa

MDASRASQLINSRETDVYCKSEPVIIRSVDEYSKMATVESLNNGTTIMAPLNDIRDSGVINH

sspH1

Small, acid-soluble spore protein H 1

60 amino acids

Belongs to the SspH family.

6.698 kDa

MDVRRAQEIASSPVMANVTYNGQRIYIEHVDQQKGVATIHPLDNPNQKQSVPVASLEEHS

sspH1

Small, acid-soluble spore protein H 1

59 amino acids

Belongs to the SspH family.

6.545 kDa

MDVKRVKQILSSSSRIDVTYEGVPVWIESCDEQSGVAQVYDVSNPGESVHVHVNALEEK

sspH1

Small, acid-soluble spore protein H 1

59 amino acids

Belongs to the SspH family.

6.509 kDa

MDVKRVKQILSSSSRIDVTYEGVPVWIESCDEQSGVAQVYDVSNPGESVHVNVTALEEK

sspH1

Small, acid-soluble spore protein H 1

59 amino acids

Belongs to the SspH family.

6.552 kDa

MDVKRVKQILSSSSQIDVTYQGVPVWIESCDEGRGIAQVHDITAPHETVEVDITALEEK

sspH1

Small, acid-soluble spore protein H 1

59 amino acids

Belongs to the SspH family.

6.539 kDa

MDVKRVKQILSSSSRIDVTYEGVPVWIESCDEQKGSAQVYDVSNPGESVHVDVTALEEK

sspH1

Small, acid-soluble spore protein H 1

59 amino acids

Belongs to the SspH family.

6.958 kDa

METLRAKRIAEAGEVVPVMYEGKSVIIQHVDEEQEMARIYFVDEPEREQDVPVRLLEER