ssl3

MAU2 chromatid cohesion factor homolog

559 amino acids

Involved in sister chromatid cohesion. Forms a complex with mis4, which is required for the association of the cohesin complex with chromosomes.

Belongs to the SCC4/mau-2 family.

64.772 kDa

MTGLNETDARILVTSRHLFLWPLAETYFKNAEKVLQDCGVCDSFGRLLSTGLQCLYSVLMDTKMEPRVELLTRKRICEVLLSHTVEYADVEAILNRALIIAEQHNLTEYKFSLQLLLSRVFCRTSPKAAKVLLTRCVREAEEYAKVAEIYHSNNQSNPHRWVYEFLLATLEFQNVSQVANSIHNYANHHKHQHLQLLAMILNQSLPMDEISTDSDQISILCLVTQIAQCLRKGEILLAREILPKIHSKLESETFVWPSSYIDFFIDDTSKISIKWMSINQLYLLIYLISGFCYISDSTSGRASRFLQEGLRITGDFKHQERCVLEYLESQKWINNITKDMKYYLIATYLSRSRLSKAERILQSTEDDQTGFLGILKGMYLQKRGDLKKAEVHYRETAKNFSFRTDTFIISTLNLINILEDSAAASRCLESIEPLCNKHEKKIFKLWLLVLKVIREGPQVHQSNVLPRVIQQSSEYANTQLQYISLTELSERFGKLEHAEKMAISALELAKKSKDELWCLISGRILEDFYRSVQKYDKMRQQALENSAYSKLIEDIYSFV

SSL3

Protein STRICTOSIDINE SYNTHASE-LIKE 3

390 amino acids

Belongs to the strictosidine synthase family.

44.037 kDa

MAMSILAKIFLVFAIYCAIDPFSHSSISKFPDFKTYKIDMPPLSSLPKERDRQNLLQNSEIRFLNEVQGPESIAFDPQGRGPYTGVADGRILFWNGTRWTDFAYTSNNRSELCDPKPSLLDYLKDEDICGRPLGLRFDKKNGDLYIADAYLGIMKVGPEGGLATSVTNEADGVPLRFTNDLDIDDEGNVYFTDSSSFFQRRKFMLLIVSGEDSGRVLKYNPKTKETTTLVRNLQFPNGLSLGKDGSFFIFCEGSIGRLRKYWLKGEKAGTSEVVALLHGFPDNIRTNKDGDFWVAVHCHRNIFTHLMAHYPRVRKFFLKLPISVKFQYLLQVGGWPHAVAVKYSEEGKVLKVLEDSKGKVVKAVSEVEEKDGKLWMGSVLMSFIAVYDLP

ssl3

Staphylococcal superantigen-like 3

356 amino acids

Secreted protein that plays an essential role in immune innate response inhibition by interacting with and inhibiting host TLR2. In turn, bacteria recognition by immune cells is impaired and cytokine production is inhibited (PubMed:22665377, PubMed:22714643). Mechanistically, by interacting with TLR2, blocks ligand binding and thus inhibits activation (PubMed:26283364). Second, by interacting with an already formed TLR2-lipopeptide complex, prevents TLR heterodimerization and downstream signaling. The interaction with host TLR2 does not involve sialyl Lewis X interactions (PubMed:26283364).

Belongs to the staphylococcal/streptococcal toxin family.

40.181 kDa

MKMRTIAKTSLALGLLTTGAITVTTQSVKAEKIQSTKVDKVPTLKAERLAMINITAGANSATTQAANTRQERTPKLEKAPNTNEEKTSASKIEKISQPKQEEQKTLNISATPAPKQEQSQTTTESTTPKTKVTTPPSTNTPQPMQSTKSDTPQSPTIKQAQTDMTPKYEDLRAYYTKPSFEFEKQFGFMLKPWTTVRFMNVIPNRFIYKIALVGKDEKKYKDGPYDNIDVFIVLEDNKYQLKKYSVGGITKTNSKKVNHKVELSITKKDNQGMISRDVSEYMITKEEISLKELDFKLRKQLIEKHNLYGNMGSGTIVIKMKNGGKYTFELHKKLQEHRMADVIDGTNIDNIEVNIK

ssl3

Staphylococcal superantigen-like 3

352 amino acids

Secreted protein that plays an essential role in immune innate response inhibition by interacting with and inhibiting host TLR2. In turn, bacteria recognition by immune cells is impaired and cytokine production is inhibited. Mechanistically, by interacting with TLR2, blocks ligand binding and thus inhibits activation. Second, by interacting with an already formed TLR2-lipopeptide complex, prevents TLR heterodimerization and downstream signaling. The interaction with host TLR2 does not involve sialyl Lewis X interactions.

Belongs to the staphylococcal/streptococcal toxin family.

39.739 kDa

MKMRTIAKTSLALGLLTTGAITVTTQSVKAEKIQSTKVDKVPTLKAERLAMINITAGANSATTQAANTRQERTPKLEKAPNTNEEKTSASKIEKISQPKQEEQKTLNISATPAPKQEQSQTTTESTTPKTKVTTPPSTNTPQPMQSTKSDTPQSPTIKQAQTDMTPKYEDLRAYYTKPSFEFEKQFGFMLKPWTTVRFMNVIPNRFIYKIALVGKDEKKYKDGPYDNIDVFIVLEDNKYQLKKYSVGGITKTNSKKVNHKVELSITKKDNQGMISRDVSEYMITKEEISLKELDFKLRKQLIEKHNLYGNMGSGTIVIKMKNGGKYTFELHKKLQEHRMAGTNIDNIEVNIK