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srtD

Gene
srtD
Protein
Sortase D
Organism
Bacillus subtilis (strain 168)
Length
198 amino acids
Function
Transpeptidase that anchors surface proteins to the cell wall (PubMed:21906378, PubMed:21800427, PubMed:22020651). Recognizes and modifies its substrate by proteolytic cleavage of a C-terminal sorting signal. Following cleavage, a covalent intermediate is formed via a thioester bond between the sortase and its substrate, which is then transferred and covalently attached to the cell wall (Probable). This sortase recognizes a Leu-Pro-Asp-Thr-Ser/Ala (LPDTS/A) motif (PubMed:21906378, PubMed:22020651). It has two substrates, YhcR and YfkN (PubMed:21906378, PubMed:21800427, PubMed:22020651).
Similarity
Belongs to the bacterial sortase family. Class D subfamily.
Mass
21.976 kDa
Sequence
MKKVIPLFIIAAGLVIAGYGGFKLIDTNTKTEQTLKEAKLAAKKPQEASGTKNSTDQAKNKASFKPETGQASGILEIPKINAELPIVEGTDADDLEKGVGHYKDSYYPDENGQIVLSGHRDTVFRRTGELEKGDQLRLLLSYGEFTYEIVKTKIVDKDDTSIITLQHEKEELILTTCYPFSYVGNAPKRYIIYGKRVT