Function
GATA-type transcription repressor that regulates iron- acquisition genes through specific binding the GATA sequence element 5'-(G/A)ATC(T/A)GATAA-3' of target promoters in an iron- and zinc-dependent manner (PubMed:18549241, PubMed:22117028). Regulation occurs via direct binding of iron ions (PubMed:18549241). Iron acquisition regulation is critical for survival under both iron-limiting conditions (to acquire essential iron) and iron-replete conditions (to limit iron toxicity) (PubMed:22117028). SRE1 targets include genes encoding a number of key iron-regulated factors such as those involved in siderophore biosynthesis, presumed ferric reductase activity, iron-responsive transcriptional regulation, oxidative stress response, as well as genes encoding a number of putative oxidoreductases, metabolic and mitochondrial enzymes, superoxide dismutase, and genes previously identified as induced during nitrosative stress (PubMed:22117028).
Sequence
MTGLLASRLRAEGARSPTKGTDIPMRQPSAEDLDAAHQLVSSARGGRDNVMNFRSDRQEMTGKALDNTQGDGSRNMDSQLQNGHKAPVEQRAGESPPESGANPIDHPTSSKKSPKAQSKEQAFTGHSCSNCGTKRTPLWRRSPTGATICNACGLYLKARNTDRPTHRSRSLLTPYGSSSAQTLDKSRSSTSPTNDGNDPRLTDTWSNYAVKECTPSGSCPGGGSCNGTGGAEGCDGCPAYNNRVYKSAARNAMALHTPRTSPQVSTQGGPGSTEGDAGSSNPETMTLHIACQNCQTTVTPLWRRDENGHPICNACGLYHKLHGAYRPPTMKKSIIKRRKRVVPAMREQSPPSATQSSNGSVSPEASPAALAHNHDSHRQYQNVEHGNGHPPPHTRPLYSHAYHAPPPADFTGYTSNVISLPHHPPSTSQQLRPYDNNHNNGETTNTHRAPMPALHNPKKRTISESSIEDSQRPQASQILTHIPQINPPTPPSSSSASFPNNNPGRFNSISSLLNHPGEAATVTAHDRDDSRVDPALSSAVAPRTQQPQQEHQHASAGSHSPPRFSPSLSPAPPSTTAVPVGGGSGSGAAAVAGVVDHRDAKAERRARLQREAQDMREALKAKERELALLE