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sqv-8

Gene
sqv-8
Protein
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase sqv-8
Organism
Caenorhabditis elegans
Length
356 amino acids
Function
Glycosyltransferase required for the biosynthesis of the tetrasaccharide (GlcA-Gal-Gal-Xyl-)Ser core linker of heparan sulfate and chondroitin sulfate (PubMed:11005858). May be involved in the biosynthesis of the HNK-1 carbohydrate epitope on glycoproteins (PubMed:11005858). Required for embryonic development (PubMed:9927677). Involved in the elongation of the pharyngeal isthmus during the later stages of embryonic development (PubMed:16828468). Involved in vulval epithelium invagination (PubMed:9927677).
Similarity
Belongs to the glycosyltransferase 43 family.
Mass
41.089 kDa
Sequence
MFPSRLLEKWWLRAFIALVIFFVWQLFYAINRVQSLEEERATLQATIEVLTRKSDGLRTQIFEKERNLVRLNGKVEEIDTQIRDHLSLLPRVNRSTPFIYFITPTHFRAAQRADLTRLSYTLSHVPNLHWIVVEDSDELTPSIAGILKRSKIPNTHLNARTPSDQKMRYDDPNWTLPRGVEQRNRALLWIQNQLSGVKEGVVYFGDDDNTYDLKIFGEMRKVKNAGVWPVGIVGGMFVETPILEKNGSISHFNAVWKPERPFPIDMAAFAVNISLVLSNANALFSFDVPRGYQESTFLENLGIHRYNMEPLAEMCTKVYVWHTRTEKPKLSKESIDRLTKKTGFNSLEAHALGVDN