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sqv-6

Gene
sqv-6
Protein
Xylosyltransferase sqv-6
Organism
Caenorhabditis elegans
Length
806 amino acids
Function
Catalyzes the first step in biosynthesis of glycosaminoglycan. Transfers D-xylose from UDP-D-xylose to specific serine residues of the core protein. Initial enzyme in the biosynthesis of chondroitin sulfate and dermatan sulfate proteoglycans in fibroblasts and chondrocytes. Required for vulval morphogenesis and zygotic cytokinesis, suggesting that glycosaminoglycans play a central role in vulval morphogenesis.
Similarity
Belongs to the glycosyltransferase 14 family. XylT subfamily.
Mass
93.115 kDa
Sequence
MLFNGTTKYRDYAIVISLFFLLNVYLLYNTAQHTQVGNSKHISSDSGEKTSNPLPSCEITDDLAKSAISRAITPSCKAKLQLEACQLKNGTFTINFPENQCPNHDSRLIDQRIGCFLDKKEARVLTEFEYKLPKSNGKATCRKHCYKAGFLYFGLEFGHECFCGNDVSNATAVDDVECRAYKCPGNENSEEFCGGFNAVEIFRTGFRSKVNHRKPTYLPPSSDSIKNPVKILFLLQLNGRNERQVKRFLKSIYLPHHYYYIHVDARQNYMFSEMQKVADFLDNIHITERRFSTIWGGASLLQMFLQVIRDSMKIEKFKDWDYIINFSESDFPILPISDFERLITVNNGKSFLASHGYNTGKFIQKQGFEYVFSECDNRMFRIGKREFPQNLRIDGGSDWVGIHRNLAEFSISDEELPRKLRKTYESILLPLESFYHTLAFNSEFCDDLLMSNLRLTNWYRKQGCRCASLKPIVDWCGCSPLVFREETMKKFELQKAISKPTYFARKFDSMVDIDSIEAAEMQSISPEKLQLNHPTYHFAFANIFKTGIDEQKLHFESLANFALKSTETRAKFRKVLRIDALRAHHNALIEIVMKIETTDGATFEFLIHRLSHVNLTENEEKLVEHGYLLRAVSFGTKFEWKEELCREYMGFVTDNDTLHTRLQWHPTEHVKKVGDKTSPEMIFKYRKGDELIEQTVVKPYDSVFGGQFDSWNVGKKLSNLTTCSNFFVDIISPSSPDDAPPLATLHFPVYTDQNAHCHVDYLRQFFKIADFCTSGDACKEKIWSTSYPDPKSDIFVGYDEDTQTLI
Protein
Xylosyltransferase sqv-6: sqv-6

Gene
sqv-6
Protein
Xylosyltransferase sqv-6
Organism
Caenorhabditis briggsae
Length
803 amino acids
Function
Catalyzes the first step in biosynthesis of glycosaminoglycan. Transfers D-xylose from UDP-D-xylose to specific serine residues of the core protein. Initial enzyme in the biosynthesis of chondroitin sulfate and dermatan sulfate proteoglycans in fibroblasts and chondrocytes.
Similarity
Belongs to the glycosyltransferase 14 family. XylT subfamily.
Mass
92.745 kDa
Sequence
MVVVGGVNTNYRHYALVIVLFFFLNVYLLYSAQNSVQIRKDEGETREKFQTPKVPLVDPISTCEIVDELAKSAISRATSPGCKSKLQLEACQLKNGTFSESFPQSTCSNHQDALIDQRIGCFLDKKDARVLKEFEYKFPQSNSKSTCRKNCYKAGFLYYGLEFGLECFCGNDVANATEIDSGECRNYKCPGAEDEFCGGFNAVEIFRTDKLVMLKPKYLPPAENVSKPPIKILFLLQLNGRNERQVKRFLKSIYLPNHYYYIHVDKRQNYMYSEMAKIAEKVPNIHITSTRYSTIWGGASLLQMFQQVIRDSMEIEMFKDWDYIFNFSESDFPILPIQDFERLITEHQGKSFLASHGYNTGKFIQKQGFEFVFSECDQRMFRIGKREFPENLRIDGGSDWVGIHRDLAEYSISNEELPQKLRKTFESILLPLESFYHTLAFNSKFCDDLMMSNLRLTNWLRKQGCRCASLKQIVDWCGCSPLVFREDTKIKFEMQKAISKPTYFARKFDSMVDIEAIESAEQQSMSTSKIQMDHPTYHFAYANIFKFGIDEEKIAHRSLASFALNTIKSHEKMAKIVQIDALRAHHNAQIEIVMKVETQSGANFEFLIHRKSHVNLSTSGALEVDGYVLKDVVYGTKFEWKEEICREYMGFVTEKDTLHTRLEWSPTERVKKNDKTSPEIEFQYRNGPEKIDKSIVKPYDSVFGGQFDSWDVGKRLSNLSTCPDFFVDVFSPSSSESPLATLRFSVYTEQNVDCHVAYLRDFFEIVDFCTSETACGEKIWSMSYPDPKSDIQVGWDEEARILR
Protein
Xylosyltransferase sqv-6: sqv-6