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sqv-5

Gene
sqv-5
Protein
Chondroitin sulfate synthase sqv-5
Organism
Caenorhabditis elegans
Length
736 amino acids
Function
Has both beta-1,3-glucuronic acid and beta-1,4-N-acetylgalactosamine transferase activity (PubMed:12761549). The beta-1,3-glucuronic acid transferase activity is controversial as it is not detected using the purified recombinant enzyme (PubMed:12761550). Adds the first N-acetylgalactosamine(GalNAc) to initiate the chondroitin chain. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and GalNAc from UDP-GalNAc to the non-reducing end of the elongating chondroitin polymer (PubMed:12761549, PubMed:12761550). Together with mig-22, required for chondroitin synthesis (PubMed:15485872). Plays a role in early embryonic development by controlling cell division and cytokinesis (PubMed:12761550). In addition, involved in vulva morphogenesis and in the directed migration of gonadal distal tip cells and hermaphrodite specific neurons (PubMed:12761549, PubMed:16982046, PubMed:24052309). May be required for nunc6/netrin-mediated dorsal guidance of distal tip cells (PubMed:16982046).
Similarity
Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
Mass
83.557 kDa
Sequence
MRVFQRSTCRMPVSRATVTILLGILFGFSITYYLTALKSLTNPIICGPEQQIGGFDYLDVISQRADADVFTRSQSLPGHRRGLILVAIMTAAKYVDTRAYNVWKTWAQHIPGRVLIFVAEGTESVHEDMPLIRLKGVDDTYPPQKKSFAMVKWLAENMADEYDWFLRADDDLYIRGEELALFLRSVDSSKAHIIGQAGLGNSAEYGLLALGSTDNYCMGGPGIVMSRDTLLKVSPHLESCLQHMLTSHEDVELGRCIRKHVGVACTWNYEMQKLFHNNQSAIKESYAKNMKELKDAITLHPIKDPAVMRKVHLRNREIKLREARAKRSLLSSELSTAKAQTLVRMTPNRTNDLTPWEYINNNKILFCADRVNCPRHTVDLSIRTEMADTITQLFDEFNTNARQRGRVLQFQSLQYGYMRVEPTKGVDYVLDMLLWFKKFRPPNRTTISVRRHAYVQQTFGKLRSLSEGVFRSNMRANSTLIEDPTLHMIMPLRGRAAIFARFAQHLKSICARGGDDLAVSLTIVLYSSEDEMENRETIEMLRASFIPVTVIEMGDVSFSRGVALMRGAETLPANALLFFTDVDMLFTCDALKRIKSNTILNAQIYFPIVFSEFSHESWSENDKLLADAFHYGRGRGYFRHFGYGLAAMYKADLMDVGGFDTKIEGWGKEDVDLFEKAIKNGRLRVIRVPEPGLVHIYHPIHCDENMPTAQKDMCHGSKAASLASIDTLVEQIAQYT