SPY

Probable UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase SPINDLY

944 amino acids

Probable O-linked N-acetylglucosamine transferase (OGT) involved in various processes such as gibberellin (GA) signaling pathway. OGTs catalyze the addition of nucleotide-activated sugars directly onto the polypeptide through O-glycosidic linkage with the hydroxyl of serine or threonine. Probably acts by adding O-linked sugars to yet unknown proteins.

Belongs to the glycosyltransferase 41 family. O-GlcNAc transferase subfamily.

103.828 kDa

MESLQGKESNGAVPVCNGGGGAAAPPAKQQLPEGTDALRYANILRSRNKFADALQLYTTVLDKDGANVEALIGKGICLQAQSLPRQALDCFTEAVKVDPKNACALTHCGMIYKDEGHLVEAAEAYQKARSADPSYKAASEFLAIVLTDLGTSLKLAGNTEDGIQKYCEALEVDSHYAPAYYNLGVVYSEMMQFDVALTCYEKAALERPLYAEAYCNMGVIYKNRGELDAAIACYDRCLTISPNFEIAKNNMAIALTDLGTKVKIEGDINQGVAYYKKALFYNWHYADAMYNLGVAYGEMLNFEMAIVFYELALHFNPRCAEACNNLGVIYKDRDNLDKAVECYQMALSIKPNFSQSLNNLGVVYTVQGKMDAAASMIEKAILANPTYAEAYNNLGVLYRDAGSITLSVQAYERCLQIDPDSRNAGQNRLLAMNYIDEGSDDKLYDAHREWGKRFMKLYAQYTSWDNPKVADRPLVIGYVSPDFFTHSVSYFVEAPLTHHDYTKCKVVVYSGVVKADAKTLRFKDKVLKKGGVWRDIYGIDEKKVATLVREDKVDILVELTGHTANNKLGTMACRPAPIQVTWIGYPNTTGLPAIDYRITDSLADSPNTNQKHVEELVRLPESFLCYTPSPEAGPVCPTPAISNGFITFGSFNNLAKITPKVMQVWARILCAVPNSRLVVKCKPFCCDSIRQKFLSTLEELGLESLRVDLLPLIHLNHDHMQAYSLMDISLDTFPYAGTTTTCESLYMGVPCVTMAGSVHAHNVGVSLLTKVGLGRLVAKTEDEYVSLALDLASDVSALEELRKSLRELMIKSPVCDGESFTRGLESAYRSMWHRYCDGDSPALRRLEVLADQTGEDLNKTAVKLADLKAQRVNATAEEDNQSPVTKFDATSKGGEQPQPQIMVNGVTSPEGNQAVKAQPQIMVNGVSSPHSPSGRCEANGHSSR

SPY

Probable UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase SPINDLY

932 amino acids

Probable O-linked N-acetylglucosamine transferase (OGT) involved in various processes such as gibberellin (GA) signaling pathway. OGTs catalyze the addition of nucleotide-activated sugars directly onto the polypeptide through O-glycosidic linkage with the hydroxyl of serine or threonine. Probably acts by adding O-linked sugars to yet unknown proteins.

Belongs to the glycosyltransferase 41 family. O-GlcNAc transferase subfamily.

103.94 kDa

MAWTEKDVENGKESDSLGNNGFLKGVQSSSDSKGSPVRISPVKKSFEGKDAITYANILRSRNKFVDALAIYESVLQKDSGSIESLIGKGICLQMQNMGRLAFESFAEAIKLDPQNACALTHCGILYKDEGRLVEAAESYQKALKADPSYKPAAECLAIVLTDIGTSLKLAGNSQEGIQKYYEAIKIDSHYAPAYYNLGVVYSEMMQYDMALNCYEKAAIERPMYAEAYCNMGVIYKNRGDLESAIACYERCLAVSPNFEIAKNNMAIALTDLGTKVKLEGDINQGVAYYKKALYYNWHYADAMYNLGVAYGEMLKFDMAIVFYELAFHFNPHCAEACNNLGVIYKDRDNLDKAVECYQMALTIKPNFSQSLNNLGVVYTVQGKMDAAASMIEKAIIANPTYAEAYNNLGVLYRDAGNISLAIEAYEQCLKIDPDSRNAGQNRLLAMNYINEGSDDKLYEAHRDWGWRFMRLYQQYNSWDNSKDPERQLVIGYVSPDYFTHSVSYFIEAPLAYHDYANYKVVIYSAVVKADAKTNRFRDKVLKKGGVWRDIYGIDEKKVSSMIREDKVDIMIELTGHTANNKLGMMACRPAPVQVTWIGYPNTTGLPTIDYRITDSMADPPSTKQKHVEELVRLPDSFLCYTPSPEAGPVSPAPALTNGFVTFGSFNNLAKITPKVLQVWARILCAVPHSRLIVKCKPFGCDSVRQRFLSILEQLGLEPQRVDLVPLILLNHDHMQAYSLMDISLDTFPYAGTTTTCESLYMGVPCVTMGGSVHAHNVGVSLLKTVGLRKLVARNEDEYVELAIQLASDVTSLSNLRMSLRELMAKSPLCDGAQFTQNLESTYRSMWRRYCDGDVPSLRRMELLQQQQQTLAELVVPEESPVSPIEKTRISASKDGPIKENGFTVSPALVYNSSTIEENGVQLNQAGNPGKQS

SPY

Probable UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase SPINDLY

931 amino acids

Probable O-linked N-acetylglucosamine transferase (OGT) involved in various processes such as gibberellin (GA) signaling pathway. OGTs catalyze the addition of nucleotide-activated sugars directly onto the polypeptide through O-glycosidic linkage with the hydroxyl of serine or threonine. Probably acts by adding O-linked sugars to yet unknown proteins (By similarity).

Belongs to the glycosyltransferase 41 family. O-GlcNAc transferase subfamily.

103.492 kDa

MAWTEKDVENGKESESLGNNGFLKGGQSSSGSKGSPGRISHVKKIFEDKDAITYANILRSRNKFVDALAIYESVLEKDSKSIESLIGKGICLQMQNTGRLAFESFSEAIKVDPQNACALTHCGILYKDEGRLVEAAESYEKALKADPSYTPAAECLAIVLTDIGTSLKLAGNTQEGIQKYYEAIKIDSHYAPAYYNLGVVYSEMMQYDMALNCYEKAALERPMYAEAYCNMGVIFKNRGDLESAIACYERCLAVSPNFEIAKNNMAIALTDLGTKVKLEGDINQGVAYYKKALCYNWHYADAMYNLGVAYGEMLKFDMAIVFYELAFHFNPHCAEACNNLGVIYKDRDNLDKAVECYQLALSIKPNFSQSLNNLGVVYTVQGKMDAAASMIEKAIIANPTYAEAYNNLGVLYRDAGNISLAIEAYEQCLKIDPDSRNAGQNRLLAMNYINEGTDDKLYEAHRDWGRRFMKLYPQYTSWDNSKVPERPLVIGYVSPDYFTHSVSYFIEAPLAHHDYTNYKVVVYSSVVKADAKTNRFRDKVMKKGGLWRDIYGIDEKKVSSMIREDKVDIMVELTGHTANNKLGTMACRPAPVQVTWIGYPNTTGLPTIDYRITDAMADPPNAKQKHVEELVRLPNSFLCYTPSPEAGPVCPAPALSNGFVTFGSFNNLAKITPKVLKVWARILSAVPHSRLIVKCKPFCCDSVRQRFLSILEQLGLEPQRVDLLPLILLNHDHMQAYSLMDISLDTFPYAGTTTTCESLYMGVPCVTMGGSVHAHNVGVSLLKTVGLENLVARNEDEYVESAIQLASDVTSLSNLRMSLRELMSKSPLCDGAKFTRNIESIYRSMWRRYCDGDVPSLRRMELLQQQQTQTESVVPEESSVNPSERTITSAPTDGSIKENGFTAVPALALKSSTSEENGVQSNHNGNHGNLS

SPY

Probable UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase SPINDLY

927 amino acids

Probable O-linked N-acetylglucosamine transferase (OGT) involved in various processes such as gibberellin (GA) signaling pathway. OGTs catalyze the addition of nucleotide-activated sugars directly onto the polypeptide through O-glycosidic linkage with the hydroxyl of serine or threonine. Probably acts by adding O-linked sugars to yet unknown proteins (By similarity).

Belongs to the glycosyltransferase 41 family. O-GlcNAc transferase subfamily.

102.548 kDa

MGRPGMDSSEGRESNGVVPERNGGAVPAKQQLDGKDTLRYANILRSRNKFAEALQLYNNVLEKDEANVEALIGKGICLQAQSLPMQAIECFNEAVRIDPGNACALTYCGMIYKDEGHLVEAAEAYQKARNADPSYKPAAEFLAIVLTDLGTSLKLAGNTEEGIQKYCEALEVDSHYAPAYYNLGVVYSEMMQFDLALTCYEKAALERPLYAEAYCNMGVIYKNRGELEAAIACYERCLTISPNFEIAKNNMAIALTDLGTKVKIEGDINQGVAYYKKALFYNWHYADAMYNLGVAYGEMLNFEMAIVFYELALHFNPRCAEACNNLGVIYKDRDNLDKAVECYQMALSIKPNFSQSLNNLGVVYTVQGKMDAASSMIQKAIFANSTYAEAYNNLGVLYRDAGSITSAVQAYEKCLQIDPDSRNAGQNRLLALNYIDEGFDDKLYQAHREWGKRFLKLYPQYTSWDNPKVADRPLVIGYVSPDYFTHSVSYFIEAPLAHHDYSNYKVVVYSGVVKADAKTLRFKDKVLKKGGLWRDIYGIDEKKVASLVREDKVDILVELTGHTANNKLGTMACRPAPIQVTWIGYPNTTGLPTIDYRITDSLADPPDTTQKHVEELVRLPESFLCYSPSPEAGPVCPTPAILNGFITFGSFNNLAKITPKVLQVWAKILCAVPNSRLVVKCKPFCCDSIRQKFLSTLAELGLEPLRVDLLPLIHLNHDHMQAYSLMDISLDTFPYAGTTTTCESLYMGVPCVTMAGSVHAHNVGVSLLTKVGLGRLVAKSENEYVSLALDLAADVTALQELRMSLRGLMAKSPVCDGENFTRGLESAYRNMWRRYCDGDAPALRRLDLLQEEPCSNNNKQDFDDNQVAKLADLKAQRVDAAVDGDKQSQLTAHAAVVGEVQQAPIMVNGVSSPVSSGKVEANGHISR

SPY

Probable UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase SPINDLY

918 amino acids

Probable O-linked N-acetylglucosamine transferase (OGT) involved in various processes such as gibberellin (GA) signaling pathway. OGTs catalyze the addition of nucleotide-activated sugars directly onto the polypeptide through O-glycosidic linkage with the hydroxyl of serine or threonine. Probably acts by adding O-linked sugars to yet unknown proteins (By similarity). May function as a negative regulator of GA signal transduction during vernalization, inhibiting adventitious shoot elongation during vernalization.

Belongs to the glycosyltransferase 41 family. O-GlcNAc transferase subfamily.

102.154 kDa

MIEKAIVAKPKGLLKGVQSSSDSKGSPVKKSLEGKEAITYAKILRSRNKFVDALAIYELEKDSKNVEAHIGKGICLQTQNKGNLAFDCFSEAIRLDPHNACALTHCGILYKDEGRLVEAASYQKALQADPSYKPAAECLATVLNDLGTSLKGNTQEGIQKYYEAVKIDPHYAPACYNLGVVYSEMMQYDVALSCYERAATESPTYADAYCNTGIIYKNRGDLCLAVSPNFEIAKNNMGIALTDLGTKEKLEGDIDQGVAYYKKALYYNWHYSDAMYNLGVAYGEMLKFDMAIIFDELAFHFNPHCAEACNNLGVIYKDRDNLDKAVECYQKALSIKPNFSQSLNNLGVVFTVQGKMDAAASMIEKAIVANPTYAEAYNNLGVLYRDAGNIFLAIEAYEQCLKIDPDSRNAGQNRLLAMNYINEGADDRLYEAHRDWGGRFMRLYSQYTSWDNPKDPERPLVIGYGSPDHFLSYFIEAPLLYHDYENFKVVTYSAVVKADAKTNRFRERVLKKGGIWRDIYGIDEKKVASMIREDKVDILIELTGHTANNKLGMMACRPAPIQVTWIGYPNTTGLPTIDYRITDSLADPLDTKQKHVEELIQLPACFLCYTPSPEAGPVSPTPALSNGFITFGSFNNLAKITPKVLQVWARILCAVSNSRLIVKCKPFCCESVRQTFLSTLEQLGLESTRVDLLPLILLNHDHMQAYSLMDISLDTFPYAGTTTTCESLYMGVPCITMRGLVHAHNVGVSLLSTVGLGHLVAKNEDDYVRLAVQLASDVTALSNLRLTLRELMSKSPLCDGPKFIQDLELTYRSMWHRYCKGDIPSLSRMEILQKEELDVVQEQLHQQPNTSPQKLVKDEPADDASGPEHGPASKDNPLVLIKINGYNTSPSSITSPSSEENGVSQTRMLNCGDQCFRV

SPY

Probable UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase SPINDLY

914 amino acids

Probable O-linked N-acetylglucosamine transferase (OGT) involved in various processes such as gibberellin (GA) signaling pathway and circadian clock. OGTs catalyze the addition of nucleotide-activated sugars directly onto the polypeptide through O-glycosidic linkage with the hydroxyl of serine or threonine. Probably acts by adding O-linked sugars to yet unknown proteins. Acts as a repressor of GA signaling pathway to inhibit hypocotyl elongation. Functions with GIGANTEA (GI) in pathways controlling flowering, circadian cotyledon movements and hypocotyl elongation. Acts as a light-regulated promoter of elongation via its interaction with GI. Acts as an activator of cytokinin signaling. Required with SEC for gamete and seed development. Its OGT activity has been proved in vitro but not in vivo.

Belongs to the glycosyltransferase 41 family. O-GlcNAc transferase subfamily.

101.43 kDa

MVGLEDDTERERSPVVENGFSNGSRSSSSSAGVLSPSRKVTQGNDTLSYANILRARNKFADALALYEAMLEKDSKNVEAHIGKGICLQTQNKGNLAFDCFSEAIRLDPHNACALTHCGILHKEEGRLVEAAESYQKALMADASYKPAAECLAIVLTDLGTSLKLAGNTQEGIQKYYEALKIDPHYAPAYYNLGVVYSEMMQYDNALSCYEKAALERPMYAEAYCNMGVIYKNRGDLEMAITCYERCLAVSPNFEIAKNNMAIALTDLGTKVKLEGDVTQGVAYYKKALYYNWHYADAMYNLGVAYGEMLKFDMAIVFYELAFHFNPHCAEACNNLGVLYKDRDNLDKAVECYQMALSIKPNFAQSLNNLGVVYTVQGKMDAAASMIEKAILANPTYAEAFNNLGVLYRDAGNITMAIDAYEECLKIDPDSRNAGQNRLLAMNYINEGLDDKLFEAHRDWGWRFTRLHPQYTSWDNLKDPERPITIGYISPDFFTHSVSYFIEAPLTHHDYTKYKVVVYSAVVKADAKTYRFRDKVLKKGGVWKDIYGIDEKKIASMVREDKIDILVELTGHTANNKLGTMACRPAPVQVTWIGYPNTTGLPTVDYRITDSLADPPDTKQKQVEELVRLPDCFLCYTPSPEAGPVCPTPALSNGFVTFGSFNNLAKITPKVLQVWARILCAVPNSRLVVKCKPFCCDSIRQRFLTTLEQLGLESKRVDLLPLILFNHDHMQAYSLMDISLDTFPYAGTTTTCESLYMGVPCVTMAGSVHAHNVGVSLLTKVGLGHLVAKNEDEYVQLSVDLASDVTALSKLRMSLRDLMAGSPVCNGPSFAVGLESAYRNMWKKYCKGEVPSLRRMEMLQKEVHDDPLISKDLGPSRVSVTGEATPSLKANGSAPVPSSLPTQSPQLSKRMDSTS

spy

Periplasmic chaperone Spy

161 amino acids

An ATP-independent periplasmic chaperone, decreases protein aggregation and helps protein refolding. Binds substrate over a large region. Protect proteins in vitro against tannin inactivation; tannins have antimicrobial activity. Overexpression enhances the stability of otherwise unstable periplasmic proteins (PubMed:21317898).

Belongs to the CpxP/Spy family.

18.171 kDa

MRKLTALFVASTLALGAANLAHAADTTTAAPADAKPMMHHKGKFGPHQDMMFKDLNLTDAQKQQIREIMKGQRDQMKRPPLEERRAMHDIIASDTFDKAKAEAQIAKMEEQRKANMLAHMETQNKIYNILTPEQKKQFNANFEKRLTERPAAKGKMPATAE

spy

Periplasmic chaperone Spy

161 amino acids

An ATP-independent periplasmic chaperone, decreases protein aggregation and helps protein refolding. Binds substrate over a large region.

Belongs to the CpxP/Spy family.

18.229 kDa

MRKLTALFVASTLALGAANLAHAADTTTAAPADAKPMMHHKGKFGPHQDMMFKDLNLTDAQKQQIREIMKGQRDQMKRPPLEERRAMHDIITSDTFDKVKAEAQIAKMEEQRKANMLAHMETQNKIYNILTPEQKKQFNANFEKRLTERPAAKGKMPATAE

spy

Periplasmic chaperone Spy

161 amino acids

An ATP-independent periplasmic chaperone, decreases protein aggregation and helps protein refolding. Binds substrate over a large region of its convex inner surface (PubMed:21317898, PubMed:24497545). Substrate protein folds while it is bound to chaperone (PubMed:26619265). Increasing Spy flexibility increases its substrate affinity and overall chaperone activity (shown for 3 different substrates) (PubMed:24497545). Protects proteins in vitro against tannin inactivation; tannins have antimicrobial activity (PubMed:21317898). Overexpression enhances the stability of otherwise unstable periplasmic proteins (PubMed:21317898).

Belongs to the CpxP/Spy family.

18.199 kDa

MRKLTALFVASTLALGAANLAHAADTTTAAPADAKPMMHHKGKFGPHQDMMFKDLNLTDAQKQQIREIMKGQRDQMKRPPLEERRAMHDIIASDTFDKVKAEAQIAKMEEQRKANMLAHMETQNKIYNILTPEQKKQFNANFEKRLTERPAAKGKMPATAE