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spxA

Gene
spxA
Protein
Regulatory protein Spx
Organism
Streptococcus agalactiae serotype III (strain NEM316)
Length
137 amino acids
Function
Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress.
Similarity
Belongs to the ArsC family. Spx subfamily.
Mass
15.846 kDa
Sequence
MITLFLSPSCTSCRKARAWLSKHEVAFEEHNIITSPLNKEELLQILSFTENGTEDIISTRSKVFQKLAIDVDELSTSSLMELISENPSLLRRPIILDKKRMQIGFNEDEIRAFLPRDYRKQELKQATIRAEIEGKHD

Gene
spxA
Protein
Regulatory protein Spx
Organism
Streptococcus agalactiae serotype V (strain ATCC BAA-611 / 2603 V/R)
Length
137 amino acids
Function
Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress.
Similarity
Belongs to the ArsC family. Spx subfamily.
Mass
15.846 kDa
Sequence
MITLFLSPSCTSCRKARAWLSKHEVAFEEHNIITSPLNKEELLQILSFTENGTEDIISTRSKVFQKLAIDVDELSTSSLMELISENPSLLRRPIILDKKRMQIGFNEDEIRAFLPRDYRKQELKQATIRAEIEGKHD

Gene
spxA
Protein
Regulatory protein Spx
Organism
Streptococcus mutans serotype c (strain ATCC 700610 / UA159)
Length
137 amino acids
Function
Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress.
Similarity
Belongs to the ArsC family. Spx subfamily.
Mass
15.968 kDa
Sequence
MVTLFLSPSCTSCRKARAWLNRHDVVFQEHNIMTSPLSRDELLKILSYTENGTEDIISTRSKVFQKLDIDVDELSVSELINLISKNPSLLRRPIIMDNKRMQIGFNEDEIRAFLPRDYRKQELRQATIRAEVEGEDD

Gene
spxA
Protein
Regulatory protein Spx
Organism
Streptococcus pyogenes serotype M1
Length
134 amino acids
Function
Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress.
Similarity
Belongs to the ArsC family. Spx subfamily.
Mass
15.528 kDa
Sequence
MVTLFLSPSCTSCRKARAWLVKHEVDFQEHNIITSPLSRDELMSILSFTENGTEDIISTRSKVFQKLDIDVEELSISDLIDLIAKNPSLLRRPIIMDQKRMQIGFNEDEIRAFLSRDYRKQELRQATIKAEIEG

Gene
spxA
Protein
Regulatory protein Spx
Organism
Streptococcus pyogenes serotype M3 (strain ATCC BAA-595 / MGAS315)
Length
134 amino acids
Function
Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress.
Similarity
Belongs to the ArsC family. Spx subfamily.
Mass
15.514 kDa
Sequence
MVTLFLSPSCTSCRKARAWLVKHEVDFQEHNIITSPLSRDELMSILSFTENGTEDIISTRSKVFQKLDVDVEELSISDLIDLIAKNPSLLRRPIIMDQKRMQIGFNEDEIRAFLSRDYRKQELRQATIKAEIEG

Gene
spxA
Protein
Regulatory protein Spx
Organism
Streptococcus pyogenes serotype M6 (strain ATCC BAA-946 / MGAS10394)
Length
134 amino acids
Function
Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress.
Similarity
Belongs to the ArsC family. Spx subfamily.
Mass
15.47 kDa
Sequence
MVTLFLSPSCTSCRKARAWLVKHEVDFQEHNIITSPLSRDELMSILSFTENGTEDIISTRSKVFQKLDIDVEELSISGLIDLIAKNPSLLRRPIIMDQKRMQIGFNEDEIRAFLSRDYRKQELRQATIKAEIEG

Gene
spxA
Protein
Regulatory protein Spx
Organism
Streptococcus pyogenes serotype M18 (strain MGAS8232)
Length
134 amino acids
Function
Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress.
Similarity
Belongs to the ArsC family. Spx subfamily.
Mass
15.528 kDa
Sequence
MVTLFLSPSCTSCRKARAWLVKHEVDFQEHNIITSPLSRDELMSILSFTENGTEDIISTRSKVFQKLDIDVEELSISDLIDLIAKNPSLLRRPIIMDQKRMQIGFNEDEIRAFLSRDYRKQELRQATIKAEIEG

Gene
spxA
Protein
Regulatory protein Spx
Organism
Streptococcus pyogenes serotype M3 (strain SSI-1)
Length
134 amino acids
Function
Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress.
Similarity
Belongs to the ArsC family. Spx subfamily.
Mass
15.514 kDa
Sequence
MVTLFLSPSCTSCRKARAWLVKHEVDFQEHNIITSPLSRDELMSILSFTENGTEDIISTRSKVFQKLDVDVEELSISDLIDLIAKNPSLLRRPIIMDQKRMQIGFNEDEIRAFLSRDYRKQELRQATIKAEIEG

Gene
spxA
Protein
Regulatory protein Spx
Organism
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Length
133 amino acids
Function
Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress.
Similarity
Belongs to the ArsC family. Spx subfamily.
Mass
15.45 kDa
Sequence
MITLFLSPSCTSCRKAKAWLEKHKVPFVEHNIMTSPLTRKELQHILSLTENGTDDIISTRSKIFQKLNIDVESISVSELLHLIEQYPSLLRRPIIIDAKRMQIGFNEDEIRAFLPRSYRKQELKEARMRAGIS

Gene
spxA
Protein
Regulatory protein Spx
Organism
Streptococcus pneumoniae (strain ATCC BAA-255 / R6)
Length
133 amino acids
Function
Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress.
Similarity
Belongs to the ArsC family. Spx subfamily.
Mass
15.45 kDa
Sequence
MITLFLSPSCTSCRKAKAWLEKHKVPFVEHNIMTSPLTRKELQHILSLTENGTDDIISTRSKIFQKLNIDVESISVSELLHLIEQYPSLLRRPIIIDAKRMQIGFNEDEIRAFLPRSYRKQELKEARMRAGIS

Gene
spxA
Protein
Regulatory protein Spx
Organism
Enterococcus faecalis (strain ATCC 700802 / V583)
Length
132 amino acids
Function
Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress.
Similarity
Belongs to the ArsC family. Spx subfamily.
Mass
15.51 kDa
Sequence
MLTLYTSPSCTSCRKARAWLQEHEIPFKERNIFSEPLNIEELKAILIMTEDGTEEIISTRSKVFQKLNMDLDELPLQDLLELVQENPGLLRRPIMIDEKRLQVGFNEDEIRRFLPRDVRQLELRQAQLMAGL

Gene
spxA
Protein
Regulatory protein Spx
Organism
Lactococcus lactis subsp. cremoris (strain MG1363)
Length
132 amino acids
Function
Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity).
Similarity
Belongs to the ArsC family. Spx subfamily.
Mass
15.03 kDa
Sequence
MITIYTAPSCTSCKKAKTWLSYHHIPFNERNLIADPLSTTEISQILQKCDDGVEGLISSRNRFVKTLGVDFEDISLSQAIKIISENPQIMRRPIIMDEKRLHVGYNEEEIRAFLPRTVRVLENGGARLRSAI

Gene
spxA
Protein
Regulatory protein Spx
Organism
Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)
Length
132 amino acids
Function
Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress.
Similarity
Belongs to the ArsC family. Spx subfamily.
Mass
15.485 kDa
Sequence
MVILYTAPSCTSCRKAKAWLQTHDIDFQEHNLFTEPLSIEKIKQILQLTESGTEEIISTRSKAFQQLNVDINDLSLNELFDMITHDPSLLRRPIMLDEKRLQVGYNEDEIRRFLPRKIRTLELLRAQQLANM

Gene
spxA
Protein
Regulatory protein Spx
Organism
Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)
Length
131 amino acids
Function
Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress.
Similarity
Belongs to the ArsC family. Spx subfamily.
Mass
15.29 kDa
Sequence
MVTLLTSPSCTSCRKAKAWLEEHNIPFEERNIFSSPLTVEEVKEVVRMTEDGTDEIISTRSKVFQELDVELEALPLQTLFKIISENPGLLRRPIIFDEKRLQVGYNEAEIRRFLPRKVRTFQLQEAQRLVN

Gene
spxA
Protein
Regulatory protein Spx
Organism
Bacillus clausii (strain KSM-K16)
Length
131 amino acids
Function
Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress.
Similarity
Belongs to the ArsC family. Spx subfamily.
Mass
15.248 kDa
Sequence
MVTLLTSPSCTSCRKAKAWLEEHDIPFEERNIFASPLSVEEVKQVVRMTEDGTDEIISTRSKVFQELDVELESLPLQKLFTIISDNPGLLRRPIIFDEKRLQVGYNDAEIRRFLPRKVRTFQLQEAQRLVN

Gene
spxA
Protein
Regulatory protein Spx
Organism
Bacillus subtilis (strain 168)
Length
131 amino acids
Function
Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress. Negatively affects competence and sporulation. Its degradation by the MecA/ClpXP complex is needed for competence development.
Similarity
Belongs to the ArsC family. Spx subfamily.
Mass
15.529 kDa
Sequence
MVTLYTSPSCTSCRKARAWLEEHEIPFVERNIFSEPLSIDEIKQILRMTEDGTDEIISTRSKVFQKLNVNVESMPLQDLYRLINEHPGLLRRPIIIDEKRLQVGYNEDEIRRFLPRKVRSFQLREAQRLAN

Gene
spxA
Protein
Regulatory protein Spx
Organism
Listeria innocua serovar 6a (strain ATCC BAA-680 / CLIP 11262)
Length
131 amino acids
Function
Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress.
Similarity
Belongs to the ArsC family. Spx subfamily.
Mass
15.582 kDa
Sequence
MVTLYTSPSCTSCRKARAWLEEHDIPYKERNIFSEPLSLDEIKEILRMTEDGTDEIISTRSKTFQKLNVDLDSLPLQQLFELIQKNPGLLRRPIIIDEKRLQVGYNEDEIRRFLPRRVRTYQLREAQKMVN

Gene
spxA
Protein
Regulatory protein Spx
Organism
Listeria monocytogenes serotype 4b (strain F2365)
Length
131 amino acids
Function
Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress.
Similarity
Belongs to the ArsC family. Spx subfamily.
Mass
15.582 kDa
Sequence
MVTLYTSPSCTSCRKARAWLEEHDIPYKERNIFSEPLSLDEIKEILRMTEDGTDEIISTRSKTFQKLNVDLDSLPLQQLFELIQKNPGLLRRPIIIDEKRLQVGYNEDEIRRFLPRRVRTYQLREAQKMVN

Gene
spxA
Protein
Regulatory protein Spx
Organism
Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
Length
131 amino acids
Function
Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress.
Similarity
Belongs to the ArsC family. Spx subfamily.
Mass
15.582 kDa
Sequence
MVTLYTSPSCTSCRKARAWLEEHDIPYKERNIFSEPLSLDEIKEILRMTEDGTDEIISTRSKTFQKLNVDLDSLPLQQLFELIQKNPGLLRRPIIIDEKRLQVGYNEDEIRRFLPRRVRTYQLREAQKMVN

Gene
spxA
Protein
Regulatory protein Spx
Organism
Staphylococcus aureus (strain COL)
Length
131 amino acids
Function
Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress.
Similarity
Belongs to the ArsC family. Spx subfamily.
Mass
15.441 kDa
Sequence
MVTLFTSPSCTSCRKAKAWLQEHDIPYTERNIFSEHLTIDEIKQILKMTEDGTDEIISTRSKTYQKLNVDIDSLPLQDLYSIIQDNPGLLRRPIILDNKRLQVGYNEDEIRRFLPRKVRTFQLQEAQRMVD

Gene
spxA
Protein
Regulatory protein Spx
Organism
Staphylococcus aureus (strain Mu50 / ATCC 700699)
Length
131 amino acids
Function
Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress.
Similarity
Belongs to the ArsC family. Spx subfamily.
Mass
15.441 kDa
Sequence
MVTLFTSPSCTSCRKAKAWLQEHDIPYTERNIFSEHLTIDEIKQILKMTEDGTDEIISTRSKTYQKLNVDIDSLPLQDLYSIIQDNPGLLRRPIILDNKRLQVGYNEDEIRRFLPRKVRTFQLQEAQRMVD

Gene
spxA
Protein
Regulatory protein Spx
Organism
Staphylococcus aureus (strain N315)
Length
131 amino acids
Function
Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress.
Similarity
Belongs to the ArsC family. Spx subfamily.
Mass
15.441 kDa
Sequence
MVTLFTSPSCTSCRKAKAWLQEHDIPYTERNIFSEHLTIDEIKQILKMTEDGTDEIISTRSKTYQKLNVDIDSLPLQDLYSIIQDNPGLLRRPIILDNKRLQVGYNEDEIRRFLPRKVRTFQLQEAQRMVD

Gene
spxA
Protein
Regulatory protein Spx
Organism
Staphylococcus aureus (strain MRSA252)
Length
131 amino acids
Function
Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress.
Similarity
Belongs to the ArsC family. Spx subfamily.
Mass
15.441 kDa
Sequence
MVTLFTSPSCTSCRKAKAWLQEHDIPYTERNIFSEHLTIDEIKQILKMTEDGTDEIISTRSKTYQKLNVDIDSLPLQDLYSIIQDNPGLLRRPIILDNKRLQVGYNEDEIRRFLPRKVRTFQLQEAQRMVD

Gene
spxA
Protein
Regulatory protein Spx
Organism
Staphylococcus aureus (strain MSSA476)
Length
131 amino acids
Function
Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress.
Similarity
Belongs to the ArsC family. Spx subfamily.
Mass
15.441 kDa
Sequence
MVTLFTSPSCTSCRKAKAWLQEHDIPYTERNIFSEHLTIDEIKQILKMTEDGTDEIISTRSKTYQKLNVDIDSLPLQDLYSIIQDNPGLLRRPIILDNKRLQVGYNEDEIRRFLPRKVRTFQLQEAQRMVD

Gene
spxA
Protein
Regulatory protein Spx
Organism
Staphylococcus aureus (strain MW2)
Length
131 amino acids
Function
Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress.
Similarity
Belongs to the ArsC family. Spx subfamily.
Mass
15.441 kDa
Sequence
MVTLFTSPSCTSCRKAKAWLQEHDIPYTERNIFSEHLTIDEIKQILKMTEDGTDEIISTRSKTYQKLNVDIDSLPLQDLYSIIQDNPGLLRRPIILDNKRLQVGYNEDEIRRFLPRKVRTFQLQEAQRMVD

Gene
spxA
Protein
Regulatory protein Spx
Organism
Staphylococcus epidermidis (strain ATCC 35984 / RP62A)
Length
131 amino acids
Function
Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress.
Similarity
Belongs to the ArsC family. Spx subfamily.
Mass
15.424 kDa
Sequence
MVTLFTSPSCTSCRKAKAWLQEHDIPYTERNIFSEHLTIDEIKQILKMTEDGTDEIISTRSKTYQKLNVDIDSLPLQDLYSIIQDNPGLLRRPIILDDKRLQVGYNEDEIRRFLPRKVRTFQLQEAQRLVD

Gene
spxA
Protein
Regulatory protein Spx
Organism
Staphylococcus epidermidis (strain ATCC 12228)
Length
131 amino acids
Function
Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress.
Similarity
Belongs to the ArsC family. Spx subfamily.
Mass
15.424 kDa
Sequence
MVTLFTSPSCTSCRKAKAWLQEHDIPYTERNIFSEHLTIDEIKQILKMTEDGTDEIISTRSKTYQKLNVDIDSLPLQDLYSIIQDNPGLLRRPIILDDKRLQVGYNEDEIRRFLPRKVRTFQLQEAQRLVD

Gene
spxA
Protein
Regulatory protein Spx
Organism
Staphylococcus haemolyticus (strain JCSC1435)
Length
131 amino acids
Function
Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress.
Similarity
Belongs to the ArsC family. Spx subfamily.
Mass
15.422 kDa
Sequence
MVTLFTSPSCTSCRKAKAWLQEHDIPYTERNIFSEHLTIDEIKQILKMTEDGTDEIISTRSKTYQKLNVDIDSLPLQDLYAIIQDNPGLLRRPIILDEKRLQVGYNEDEIRRFLPRKVRTFQLQEAQRLVD

Gene
spxA
Protein
Regulatory protein Spx
Organism
Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229 / NCIMB 8711 / NCTC 7292 / S-41)
Length
131 amino acids
Function
Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress.
Similarity
Belongs to the ArsC family. Spx subfamily.
Mass
15.44 kDa
Sequence
MVTLFTSPSCTSCRKAKAWLQEHDIPYTERNIFSEHLTIDEIKQILKMTEDGTDEIISTRSKTYQKLNVDIDALPLQDLYSIIQDNPGLLRRPIILDEKRLQVGYNEDEIRRFLPRKVRTFQLQEAQRMVD