Protein
Regulatory protein Spx
Organism
Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229 / NCIMB 8711 / NCTC 7292 / S-41)
Function
Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress.
Similarity
Belongs to the ArsC family. Spx subfamily.
Sequence
MVTLFTSPSCTSCRKAKAWLQEHDIPYTERNIFSEHLTIDEIKQILKMTEDGTDEIISTRSKTYQKLNVDIDALPLQDLYSIIQDNPGLLRRPIILDEKRLQVGYNEDEIRRFLPRKVRTFQLQEAQRMVD