Protein
Transcription elongation factor spt-6
Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Function
Plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression (By similarity).
Similarity
Belongs to the SPT6 family.
Sequence
MSNSMRDLIDGEAELDDEEDDESFDEEAGDRPRRRPNIDDSSEEEEDDEDEEEARKIREGFIVDEDEEDEAEDSDARERRRRKKRRREREEEEQLDEEDLDLIGEAIPEWERKPQPQRLKRGHRDDHRPTERRGLAEIFSDEDEEHDDRGYGRPSGRAQADEFDDFIEDDYPEDDEERRHREEDEEVARPKDRGLNIDTTGLDKDALEDMDAIFGNGEDYEWALQLEEEQEHAERTKEDIELQDVFEPSQLKEKLLTDEDNRIRFNDEPERFQLDRKAFKNLQMTSDQFKEEARWISNLMLPSKNLSSELHGPFNKAVGKVLEFFVIDGVEVPYVFQHRRDYLIHAKKMRNPNRRDDPDAPEYTVDAEKLLTQDDLWKVLDLDIRFRSFLEKRNALEQTYDKLKEKTRDDILEEMIRQAQSIEELQDLQDYLNFQYSAELKDLAANDNSAQREIKRAGGRTAQFERIRRSNAYKFVQALGITPDRLAKNILRESSKVTSEDDSRLPDDLADTLVDADFPTGELVINAARQMLAEEMFASPRMRKHFRKNFYGMGIVSCRRTDKGLRKIDEANPYYEVKYLKNMSIADLAVRPELFLKMMKAEEEGLIEIKVSLENDREFRQQLFSDFASENFSELADKWNAERQKVIDLAFDKLVKVIVKGVKDSLRTACQDELLKTCRELYFKRLDQAPYKPKGMVIGTTPRVLTLSNGMGDPNREPVSWVSMDEDGRILEHGTFTNLARDESQREALAELVRRRQPDVIGISGFSADTHRLIKDVEGLVSEKGLVGPEYDDPETNEYRSDLLEVIVINDEVARLYKDSPRAVADHPSLNPMTRYCIALARYMQNPMKEYAALGKDVTSLQIHPYQQYLPQAKLLKHLETAMVDMVNLVGVDINVAMQDANTAHLLPYVAGLGPRKAQLLIKGINKNGGVVTSRDELVGDPERHKLPVLGPRVWNNCASFLFIEYEPTNPESDPLDNTRIHPEDYDLARKVAADALGLDEEDVKAETDENGAGAIVRKLFKDDEQDKVNELILEEYAEQLEREYQQRKRATLETIRAELQVPYEELRKKFESLTVDQVFTMLTGENRDSLCEGMIVAANVRVVKDDFAIVKLDCGIEGRIESHDVSYRHSIKDVLHVGQVVQAKLIDLNRKEFVSKLSMRDEEMRRPFRRHFDHGRDQWDYRKEDEDREELREKDKSTGRAQRVVNHPLFKPFNSTQAEEYLGSQPSGEVVIRPSSKGNDHLAVTWKVADGVFQHVDVLELQKENEFAVGRVLRVGKYTYQDLDELIVDHVKAMAKKVDELMQCDKFQKGSRNETEKWLTTYMDANPNRSTYAFCIDTKHPGYFFLCFKASRNSRVNAWPVRVIPHAFELMKSQYPDVRALCNGFKLRYQSEMLKQQSGGR