About Products Protein Database Contact

sprA

Gene
sprA
Protein
Streptogrisin-A
Organism
Streptomyces griseus
Length
297 amino acids
Function
Has a primary specificity for large aliphatic or aromatic amino acids.
Similarity
Belongs to the peptidase S1 family.
Mass
29.663 kDa
Sequence
MTFKRFSPLSSTSRYARLLAVASGLVAAAALATPSAVAAPEAESKATVSQLADASSAILAADVAGTAWYTEASTGKIVLTADSTVSKAELAKVSNALAGSKAKLTVKRAEGKFTPLIAGGEAITTGGSRCSLGFNVSVNGVAHALTAGHCTNISASWSIGTRTGTSFPNNDYGIIRHSNPAAADGRVYLYNGSYQDITTAGNAFVGQAVQRSGSTTGLRSGSVTGLNATVNYGSSGIVYGMIQTNVCAEPGDSGGSLFAGSTALGLTSGGSGNCRTGGTTFYQPVTEALSAYGATVL

Gene
sprA
Protein
Sepiapterin reductase
Organism
Dictyostelium discoideum
Length
267 amino acids
Function
Catalyzes the production of D-threo-tetrahydrobiopterin (DH4), also known as dictyopterin, and in a much smaller amount that of it's stereoisomer L-erythro-tetrahydrobiopterin (BH4). Prefers 1-oxo-2-D-hydroxypropyl-tetrahydropterin to 6-pyruvoyltetrahydropterin as a substrate, thereby maintaining dominant production of DH4 over BH4 in sufficient supply of an aldose reductase-like enzyme. DH4 represents more than 95% of the total tetrahydrobiopterin production. It has a direct antioxidant function to protect mitochondria against oxidative stress.
Similarity
Belongs to the sepiapterin reductase family.
Mass
30.187 kDa
Sequence
MSKVLAIVTGASKGFGKAIAQEIVKCNPNKNQLIDLVLFARSLDGLKSTKESIETISTNAKVIDLQSLDMSNIPDVELKFKSVLENIKWEEYSKICFFNNHGTLYHLGRIEDFSDFKNIQKDNDTNTTSFVVTTSLLVKKLKELGSQYSSEVTIVNSSSLCAIKAFPTWSLYCSSRAYRDMFFQALSLEYKLNDKFKVLNYSLGVLDTDMQSQVREECSEDDKSFYVGLKNDGKLINPNRSASICSNLVYSHKFETGSHLDYYDLDK