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spoIISA

Gene
spoIISA
Protein
Stage II sporulation protein SA
Organism
Bacillus anthracis
Length
248 amino acids
Function
Toxic component of a type II toxin-antitoxin (TA) system. Upon expression in E.coli growth ceases.
Similarity
Belongs to the SpoIISA toxin family.
Mass
28.704 kDa
Sequence
MSLVISNIRIGLFILAIVFLVLVFFYWRNEELYEEKKQRIRKTWYGLFIVSVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAFILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKIVVFEAAKELNTNFRGIRSQFSTIIPLEYIEQLNEQRAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHHSYFSK

Gene
spoIISA
Protein
Stage II sporulation protein SA
Organism
Bacillus subtilis (strain 168)
Length
248 amino acids
Function
Toxic component of a type II toxin-antitoxin (TA) system. Its toxic activity is neutralized by cognate antitoxin SpoIISB. Expression in the absence of SpoIISB permits sporulation to stage II, when plasmolysis zones and holes in the peptidoglycan layer are observed, resulting in cell death. Lethal when synthesized during vegetative growth in the absence of SpoIISB. In E.coli both the membrane bound and soluble domain are required in cis for toxin activity.
Similarity
Belongs to the SpoIISA toxin family.
Mass
29.061 kDa
Sequence
MVLFFQIMVWCIVAGLGLYVYATWRFEAKVKEKMSAIRKTWYLLFVLGAMVYWTYEPTSLFTHWERYLIVAVSFALIDAFIFLSAYVKKLAGSELETDTREILEENNEMLHMYLNRLKTYQYLLKNEPIHVYYGSIDAYAEGIDKLLKTYADKMNLTASLCHYSTQADKDRLTEHMDDPADVQTRLDRKDVYYDQYGKVVLIPFTIETQNYVIKLTSDSIVTEFDYLLFTSLTSIYDLVLPIEEEGEG

Gene
spoIISA
Protein
Stage II sporulation protein SA
Organism
Bacillus cereus (strain ATCC 14579 / DSM 31 / JCM 2152 / NBRC 15305 / NCIMB 9373 / NRRL B-3711)
Length
245 amino acids
Function
Toxic component of a type II toxin-antitoxin (TA) system. Upon expression in E.coli growth ceases. Upon coexpression with SpoIISB in E.coli normal growth is restored.
Similarity
Belongs to the SpoIISA toxin family.
Mass
28.307 kDa
Sequence
MISNIRIGLFVLAIVFVVLVFFYWKNEELYEEKKQRIRKTWYGLFIISVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAFILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKIVVFEAAKELNTNFRGIRSQFSIIVPLEHIEQLNEQKAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHHSYFSK