spn-E

Probable ATP-dependent RNA helicase spindle-E

1463 amino acids

Probable ATP-binding RNA helicase which plays a central role during gametogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons (By similarity).

Belongs to the DEAD box helicase family. DEAH subfamily.

167.374 kDa

MEDDDVADFFDFSKPFKRTVVSGGYINGAVKPQKLNIQTLPERAHQGTEYAEKFCREEEARLMEGWVDETLNKSTASRLEQVDDMSSVMEEDTQHLQRVRAKELMEPLFSRYNFTVTPNRLTIHQSKQDILKAIRENPVVVLQGMTGCGKTTQVPQYLLEDAYNRKEWCNIVVTQPRKIAASSIARRVAEERNCALGSLVGFKVGLKEMVSEDTRLTYVTTGVLLNKLITSKSISSYTHIILDEVHEREVDMDFLLIIVRRLLATMRNTKIILMSATIESSEFAQYFKIPGPNSLFAPQLAVSNVTQHDVSVYYLEDLEKLRVDFTIKYEQPDVHEKMYFLAAKVAVVCDRFIDEFESASTIDYKPSIIMFLPGINEIERMAEVLRNFLGDSNVNSQEQTKFTILKLHSMLPSEEQALVFTKPSPGYRKVILSTNIAESSITIPDVKFVIDFCLHRVLVADTLNNFTTLRTQWASRNNCIQRAGRCGRVMNGRVYRLVNKHFFEHGMAQSIEPEMVRCPLSNVVLKTKLLDMGPPHTILALAMSPPNLSDVSNTVLQLKELGALLRTAKGVYDLQDGDITYLGNIMSTLPLDIHLAKLVVLGYVFSVLEEAIVIAAGMNVKNIFCQLRTIEALRVKRHFANGSASDGIAILNAYNWWRSIREQGTGGDTTDWCNRYMLDRKSLIEMAELVQEITMRLKTANIRVVSGANNARWTDRERTVVLKVVMAGAFYPNYFIPTCVTDRELSDKMVYTEIGGRDPFSTVFFCGFDHSNYIGPLYRNEIRALLTERKPTSEKHQVKVEFERSTNKIFVQFQYPPDQQSGKSLYEERNSADRVHPGVYEAIKLRQLRHNQSELLVMHHNDAVAYATEHRLGVWRNHEWHPRSVEIPNAHLSVEPPIHWNRVTATVTHVEHPNKFYLRPHDEKNDNIYHDIMEKLNGCDAVLRAFPEGYAFKQRDIVAAPLPNMVTGKMARAKLLQQCLVRGVEHWTVFFMDFGLTAGVSVKSFRQLRGTPLDMFTKFPDRVFLASLAEVQPSAVRSPKDVWMEETIKHFRQLVHGQQFDVEVYSVVNRVTMVVLRHNPDDPIDLTVNRALINSHHAQLSEESYMSKMNHEKRKRVQFEMELDPMYKTQILNDISEQQRFLEDDDVDSLELPRDLLKVRLMLRGPYSPLEVKCSSTVFSGYRKPVIIEKESLNSVLLDTNPQNTHEKLLVAGCVNETSNSRLIARMTTMMPNIPGLPALMTLIFAPTCLVKKDPDETRVVGLLAGLGTDPRTGESMYPEHDMSLAVDIAIDDDDIADINALRYTMDSILHGGHNEQTPMFGEYSIESLMVKVKDYLIKILQRDRPIQDNRSMAHDFSWVKENPSTSTSSQKRLRSTAIDIYTKAIFPLYHNLNLRPMTADRMEFLRQHCKDLHLLTQSRVPLPKGGITCRLCNVTLESDHTLRIHFYSKLHCDLELKINYRR

spn-E

Probable ATP-dependent RNA helicase spindle-E

1436 amino acids

Probable ATP-binding RNA helicase which plays a central role during spermatogenesis and oogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi and govern the methylation and subsequent repression of transposons. Involved in the repression of LTR retrotransposon copia. Also involved in telomere regulation by repressing specialized telomeric retroelements HeT-A, TAHRE, and TART; Drosophila telomeres being maintained by transposition of specialized telomeric retroelements. Involved in telomeric trans-silencing, a repression mechanism by which a transposon or a transgene inserted in subtelomeric heterochromatin has the capacity to repress in trans in the female germline, a homologous transposon, or transgene located in euchromatin. Involved in the repression of testis-expressed Stellate genes by the homologous Su(Ste) repeats. Required for anteroposterior and dorsoventral axis formation during oogenesis (By similarity).

Belongs to the DEAD box helicase family. DEAH subfamily.

164.992 kDa

MDQDVMDFFDFSKEFKREVAPQGYISSDPKMMATDSIDSKVPKREVIGTEYVTEIVAKEKGLLNRTLRDECPQSKRKHTLDDLDTDDEEEETEIRRDDEYYKKYRFNLNRDKNLPIYAKREEILAAINANPVVILKGETGCGKTTQVPQYILDEGYKSGKYCNIVVTQPRRIAAISIANRVCQEREWQQDTVCSYQVGLHRPTSLEDTRLLYCTTGVLLNNLIRNKTLTHYTHIVLDEVHERDQDMDFLLIVVRRLLATNSRHVKIILMSATIDARELSDYFTTTNSIPPVISASHGRKHSIEKFYRDQMGSIKWKEEEDDQLVPQINDHGYRAAVKIIMVIDNMEREGAIHSRMSYDEALRYGAVLIFLPGIYEIDTMAENITLMLENDRNVKVFIVRCFSLMTPENQRDVFHPPPPGFRKIILTTNIAESSITVPDVSYVIDFCLTKVLVTDTATNFSSLRLTWASKANCRQRAGRVGRLRSGRVYRMVNKSFYQREMSEFGIPEMLRLPLQNSVLRAKELEMGSPVEILALALSPPNLSDIQNTILLLKEVGALFLTVDGVYNAMDGDVTYWGTIMSRLPLDPRLSRLIILGYVFNLLEEAIIMAAGLSMRGLYVHEGSSSRSTRAQFDSFWMHYIFADGSGSDLVAIWRVYLTYLNMVEIGHEQESAIRWANRFHVSLRSLKEMHLLVQELRVRCTNLGLIPFSVNPSQIMDDREKSFILKVIIAGAFYPNYFTRSKEMWNEHDRHIYQTISGHDPCRTVYFTNFGPSCMGELYTRRIKDFFHDARIPPENMDVTFQPGSEKVFVTFKQDDCVADSSKLVSVPGRVQSEVYKAVRMRLSCMQRIIRIMRPKQFMNYVQERGIGDVIEGRWIPPTKPLNVELLALPSVFSKTITGLITGIINCGKFYFQPLSLAECIRNMSEIFNAPQQLRKYVVDACDISKGMMVLAKRDSNFQRATVIRPENQSNRQPMFYVRFIDYGDCALLPMQQLRFMSEELIQQYGDLPPRVFECRLALVQPSSMVHGNYSWPTAANDLLQFVAKCGRIDIEVYSLFNNVAAVLIHMRNGTINDKLVAQKLCRRSDEDYMSRKDHDFRLRSQESGRYLSSAERQQINEEYLRSCQLPQDFDLPPPPQDLCGTNVRLKGPYSPLECSMQSIIRVGSSKRVNIDSASVNAVLLDTDPQDHHDHLIVAHATVESPNGQTLTARGTTLMPNVQGYGALMVMLFCPTMQLKCNEEGTSYVSILAGLGCDPVTGEPYYAEHDVLINLDVNILEDDLVLINQIRYYIDSVFFNFKEENYPAVSVNERESIYTQLRSLIKRLLSKDRSYIGKNMSNSDFVWETNPELPMPNEPFGKRAIFPMHSLTELKEDDMGRLMNLRENCSMLHKWRNFEGTLPHMTCKLCNQLLESVPQLRLHLLTILHRDREKQIDFCNQ

spn-E

Probable ATP-dependent RNA helicase spindle-E

1434 amino acids

Probable ATP-binding RNA helicase which plays a central role during spermatogenesis and oogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi and govern the methylation and subsequent repression of transposons. Involved in the repression of LTR retrotransposon copia. Also involved in telomere regulation by repressing specialized telomeric retroelements HeT-A, TAHRE, and TART; Drosophila telomeres being maintained by transposition of specialized telomeric retroelements. Involved in telomeric trans-silencing, a repression mechanism by which a transposon or a transgene inserted in subtelomeric heterochromatin has the capacity to repress in trans in the female germline, a homologous transposon, or transgene located in euchromatin. Involved in the repression of testis-expressed Stellate genes by the homologous Su(Ste) repeats. Required for anteroposterior and dorsoventral axis formation during oogenesis (By similarity).

Belongs to the DEAD box helicase family. DEAH subfamily.

164.881 kDa

MDDLMDFFDSSKNFKRGTLPRGCISGDPNAYTSESSDSKPIKREIIGTKDVNEIVQKEQQLMNQLVGGPSNTKRTKTLDELESDDDDKMELNEAPTVRSDEAFYEKYHFDLNRNRSLPIYAQREQIMKAIKENPVVILKGETGCGKTTQVPQYILDEAFKKREFCNIVVTQPRRIAAISIANRVCQERRWQPGTVCSYQVGLHKQSNSADTRLLYCTTGVLLNNLIRLKTLTHYTHIVLDEVHDRDQDMDFLLIVVRRLLALNSRHVKVILMSATIDTREFCKYFASCKSMPPVVAASHGRKYPLVKYYRDQLKNINWKTEPQQREPGITHEGYRDAVKILLVIDNMERKAEGQSEQSYEEAKRTGSVLIFLPGVNEIDTMAEHIEHVMNESPNIKITIVRCHSLMSSDSQEDVFQPPLSGHRKVILTTNIAESSITVTDVSYVIDFCLAKVMHIDTASNFSCLCLEWASKVNCRQRAGRVGRTRSGRVYRMVTKAFYMEEMQEFGIPEMLRSPLQSSVLKAKELDMGGPSEILALAMSPPNLTDIHNTVLLLKEVGALYTTVDGVYEQLDGDLTYWGTIMSRFPLDVRLSRLIILGYIFNCLDEAIIIAAGMSVRSLYLSGQRQRTSDAFWMHYIFADGSGSDLVGFWRVYKIYVNMCQNLPMKDSEVQWARRYNVSLRSLKEMYLLVQELQKRCAALNLVSLPVGASHMWHDREKSIILKVIIAGAFYPNYFTRNNKTIPDYDRDVYHSICGNDPCRTVYFTQFVPRYMGELYTRRVKELFLEARIPPEKIDVTFQQGSEKIFVTFKGDDDDYMNSTDVVQVPGRVTTEVYKAIRMRMNNPNRSLRVMDQNSALKYVQQRNIGVVQDSKWVPPSKQWNVELLTLPSVFDKKITGLITYIVNCGKFYFQPRSLAERIASMTEIFNAPEQLSYHVRNASAITKGLQLLARRGSKFQRAVVLKVEPQSNAIPQFLVRFIDYGDWALLAMDQLRLMRHELRRDLEELPPRMFECRLALVQPSSVTSYSNRWPQKANEMLSKLASCGPLELEVYSLVNNVAAVLIHMRDGVLNDKLVEHQLARRADEDYMSRKDHDFRIRKQKMKRYVPAAEQQQVNEEYLRFNQLPQDADLEPPPLDKCHTSIRLKGPYSPLENSMNSMLRIGMYKSVAIEKESVNAVLLDADPQDRHDQMIVAASVTESDGNDKLVARGTTLMPNIHGFGALMAMLFCPTMQIKCNPERTKYVCLLAGLGFNPDTLEPYFQEHDMVINLDVGILKDDIRIINQMRYNIDSMFFNFDANELPAVGVEGRLVIFNQLRNLLTRLLGKDRSFIERHVWNSKYVWEDMSDLEPPSEPYGKRAIFPMHGSYDLESEDMGNLLALQENCSELYDWQNFDGVMQPRNCRLCNETLESVTQLRLHLLTQLHRDREKQVGWKQQ

spn-E

Probable ATP-dependent RNA helicase spindle-E

1434 amino acids

Probable ATP-binding RNA helicase which plays a central role during spermatogenesis and oogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi and govern the methylation and subsequent repression of transposons. Involved in the repression of LTR retrotransposon copia. Also involved in telomere regulation by repressing specialized telomeric retroelements HeT-A, TAHRE, and TART; Drosophila telomeres being maintained by transposition of specialized telomeric retroelements. Involved in telomeric trans-silencing, a repression mechanism by which a transposon or a transgene inserted in subtelomeric heterochromatin has the capacity to repress in trans in the female germline, a homologous transposon, or transgene located in euchromatin. Involved in the repression of testis-expressed Stellate genes by the homologous Su(Ste) repeats. Required for anteroposterior and dorsoventral axis formation during oogenesis.

Belongs to the DEAD box helicase family. DEAH subfamily.

164.51 kDa

MDQEVMDFFDFSKELKRVAAAPQGYISSDPRLMATKFKSSEVPNRELIGTDYVSKIVAKEKCLLNGTLLNEQPQGKRIRTLDDLDTDDEGEETEIRRDDEYYKKFRFNLNRDKNLSIYAKREEILAAINAHPVVIIKGETGCGKTTQVPQYILDEAYKSGKYCNIVVTQPRRIAAISIANRVCQEREWQQNTVCSFQVGLHRPNSLEDTRLLYCTTGVLLNNLINNKTLTHYTHIVLDEVHERDQNMDFLLIVVRRLLATNSRHVKIILMSATIDAKELSDYFTTTNSIPPVITTNHRRKHSIEKFYRDQLGSIIWNEEDVGHQQVPEINKHGYRAAVKIIVIIDNMERKAAIQSRQSYDEALRYGAVLIFLPGIYEIDTMAENLTCMLENDPNIKVSIVRCFSLMTPENQRDVFNPPPPGFRKIILTTNIAESSITVPDVSYVIDFCLAKVKVTDTASSFSSLRLTWASKANCRQRAGRVGRLRSGRVYRMVNKHFYQREMPEFGIPEMLRLPLQNSVLKAKVLNMGSPVEILALALSPPNLSDIHNTILLLKEVGALYLTVDGIYDPLDGDLTYWGTIMSRLPLDTRQSRLIILGYIFNMLEEAIIIAAGLSTPGLFAHEGGRSQLGDSFWMHYIFSDGSGSDLVAIWRVYLTYLNIVENGHDQESAIRWAKRFHVSLRSLKEIHLLVQELRVRCTHLGLIPFPVNPNQMMDDREKAIMLKVIIAGAFYPNYFTRSKESCADTDRNIYQTISGHDPCRTVYFTNFKPAYMGELYTRRIKELFQEVRIPPENMDVTFQEGSQKVFVTFKQDDWIEGSSKYVPVSGRVQSEVYKAVMMRQNRVERPIHIMNPSAFMSYVQQRGIGDVIEGRWIPPTKPLNVELLALPSVFDKTISGSITCIVNCGKFFFQPQSFEECIRNMSEIFNAPQQLRNYVTNASAIAKGMMVLAKRDSYFQRATVIRPENQSNRQPMFYVRFIDYGNCTLLPMQLMRLMPRELTEQYGDLPPRVFECRLAMVQPSSVVSGNNRWSTAANDMLKTVAQCGLIDIEVYSLFNNVAAVLIHMRDGIINDKLVELMLCRRSDEDYMSRKDHDFRLRRQESARNLSTAQRQQINEEYLRSCQLPQDHDLPPPPLEKCKTVVMLKGPNSPLECTMRSITRVGLSKRVNIDHLSVNALLLDADPQDHHDHLIVAHEIAESRNGQTLTARGTTLMPNVQGFGALMVMLFSPTMQLKCNKEGTSYVSVLGGLGCDPDTNEPYFAEHDVLINLDVNILEDDVILINQIRYYIDSVFFNFKEENNPAVSVNERVSIYTQLRSLINRLLCKDRRYIERNMSNADFEWETNPELPLPNEPFGKRAIFPMHSLTELQEEDTGRLVQLRENCSMLHKWRNFEGTLPHMTCKLCNQLLESVPQLRLHLLTILHRDREKQIDYCNQ

spn-E

Probable ATP-dependent RNA helicase spindle-E

1434 amino acids

Probable ATP-binding RNA helicase which plays a central role during spermatogenesis and oogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi and govern the methylation and subsequent repression of transposons. Involved in the repression of LTR retrotransposon copia. Also involved in telomere regulation by repressing specialized telomeric retroelements HeT-A, TAHRE, and TART; Drosophila telomeres being maintained by transposition of specialized telomeric retroelements. Involved in telomeric trans-silencing, a repression mechanism by which a transposon or a transgene inserted in subtelomeric heterochromatin has the capacity to repress in trans in the female germline, a homologous transposon, or transgene located in euchromatin. Involved in the repression of testis-expressed Stellate genes by the homologous Su(Ste) repeats. Required for anteroposterior and dorsoventral axis formation during oogenesis (By similarity).

Belongs to the DEAD box helicase family. DEAH subfamily.

164.38 kDa

MDQELMDFFDFSKEFVRKQAPRGHVSSNVHAFVTESDELEKPIKREIVGKDYVKSFVEKEKKRMNGIFSSDEMASRRNKSLDDMDSDEEYEASPEIRTDAEFYEKYYFNLNRDKSLPIYAKREEIINAINENPVVIVKGETGCGKTTQVPPILFWMMVSKAKQYCNIVVTQPRRIAAISIANRVCQERQWQPGTVCGYQVGLHRQLERFADTRLLYCTTGVLLNILVNNKTLTHYTHIVLDEVHERGQEMDFLLIVIRRLLATNSRHVKVILMSATINPRELSDYFANESSAPPVIAASYGRNFTVEKYYRDQLQSINWEGHQEDINSPGITQEGYRSAIKTILVIDNMERNERGTGKSYNQSLREGSILIFLPGVGEINNMSDMLKDMANHDPIMKFNMVRCHSLMTSEDQREIFQPSPPGYRKIIMATNVAESSITVPDVSYIIDFCLEKVLVTDTSTNFSSLRLAWASKTNCRQRAGRVGRLRNGRVYRMVTKSFYQRELSEYSVPEMLRSPLQNCVLKAKELKMGTPVEMLALALSPPNLSDICNTILMLKEVGALFPTMDGTYDPRDGDITYWGTIMSKLPLDTHLSRLIILGYVFNLVDEAIIIAAGLTVRGIYIDSARLGADNYWMHYVFADGSGSDLVGIWRVYLTYLNMCENGLQKDASIQWAKRFHLSLRALSEMHLLVQDLRLRCEKLSLLPLNFPTHRISDDREKAIMLKVIIAGSFYPNYFVQSKSTSGDDRNMFSVISGLDPCRTVYFTSFTDRTMGELYTRKVKQLFPEAQIPPENMDVTFGQGSEKIFVTFKNDIYKPEGTTYVHVPGRIKAEVYKALRLRTYCNQHSLRVMEPMNALKYVKDKKIGKIVEGRWIPPSKPVAVELLALPSLFDKIIIGRITNIVSCGKFFFQPESFENCIANMSEHFNNPQQLQNCVRNAGAITKGLMLLAKRQGKYQRATVVRVDTQDSRNVRFYVRFVDYGDIERLPMAQLRLMSQDLLRHYRDLPPRLFECRLALVQPASMVSTYNAWPQKADDMLHALAKGGRVQLEIYSLVQNVAAVMIHLREGNLNELLVKEKLARRTDEDYMSRVDHDFRMRKQECRGYVSQQERQQVNEEYLRSKQLPQDMDLSPPPPEECNSLITLKGPFSTLESRVFSTMRSGMSKTVRIDPCSVNFVLLDTEPQDQHAKMVVAASISAAGRHNDVLTLRSTSIMPNIPGFAAIMTLIFCPRAQLKANTANSRYVSILAGIGYHPQTMQSYYEDHDLVINLDVNIDEHDVLLINQIRYMIDSAFFNLEGELHPTAGHADRVLIHNTIYPALNRLLSKNRNFIECNPNSSDYVWQDMEESGEPDPQPYGRRSIFPMHTIPELHEEKMDTVLDLIANCKEMYDYRNFEGSFDPMTCSLCKQYLESVAELRLHLLTQLHLDREKEVGYPID

spn-E

Probable ATP-dependent RNA helicase spindle-E

1434 amino acids

Probable ATP-binding RNA helicase which plays a central role during spermatogenesis and oogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi and govern the methylation and subsequent repression of transposons. Involved in the repression of LTR retrotransposon copia. Also involved in telomere regulation by repressing specialized telomeric retroelements HeT-A, TAHRE, and TART; Drosophila telomeres being maintained by transposition of specialized telomeric retroelements. Involved in telomeric trans-silencing, a repression mechanism by which a transposon or a transgene inserted in subtelomeric heterochromatin has the capacity to repress in trans in the female germline, a homologous transposon, or transgene located in euchromatin. Involved in the repression of testis-expressed Stellate genes by the homologous Su(Ste) repeats. Required for anteroposterior and dorsoventral axis formation during oogenesis (By similarity).

Belongs to the DEAD box helicase family. DEAH subfamily.

164.578 kDa

MDQEVMDFFDFSKELNRVPGAPQGYISSDPWLMATESKSSEVPNRETIGTDYVTKIVAKEKCRLNRTLLEYQPQGKRNRTLDDLDTDDEAEETEIRRDDEYYKKFRFNLNRDKNLSIYAKREEILAAINAHPVIIIKGETGCGKTTQVPQYILDEAYKSGKYCNIVVTQPRRIAAISIANRVCQEREWQQNTVCSFQVGLHRPNSLEDTRLLYCTTGVLLNNLINNKTLTHYTHIVLDEVHERDQNMDFLLIVVRRLLATNSRHVKIILMSATIDAKELSDYFATTNSIPPVITTNHGRKHSIEKFYRDQLGSIIWNEEDVGDQHVPEINKHGYRAAVKIIVIIDNMERKAAIQSRLSYDETLRYGAVLIFLPGIYEIDTMAENITCMLENDRNIKVLIVRCFSLMTPENQRDVFNPPPPGFRKIILATNIAESSITVPDVSYVIDFCLTKVKVTDTASSFSSLRLTWASKANCRQRAGRVGRLRSGRVYRMVNKHFYQREMAEFGIPEMLRLPLQNSVLKAKVLNMGSPMEILALALSPPNLSDIQNTILLLKEVGALYLTVDGVYDALDGDLTYWGTIMARLPLDTRQSRLIILGYIFNMLEEAIIIAAGLSTNGLFAHDGGRTQLGDSFWMHYIFADGSGSDLVAIWRVYLTYLSLVEIGHDQESAIRWAKRFHVSLRSLKEIHLLVQELRVRCMHLGLIPFSVNPSQMMDDREKAIMLKVIIAGAFYPNYFTRSKDTCADTDRNIYQTISGHDPCRTVYFTNFKPAYMGELYTRRIKELFQEVRIPPENMDVTFQEGSQKVFVTFKQDDWIADSSKFVPVSGRVQSEVYKAVMMRQNRLERPIHIMNPSAFMSYVQQRGIGDVIEGRWIPPTKPLNVELLALPSVFDKTISGLITCIVSCGKFFFQPQSFAECIGNMSEIFNAPQQLRNYVNNAGDITKGMMVLAKRDSYFQRATVIRPENQSNRQPMFYVRFIDYGDCALLSMQQMRLMPRELTEQYGDLPPRVFECRLAMVQPSSMVSGNNRWSTAANDMLRSVAKSGLIDIEVYSLFNNVAAVLIYMRDGIINDKLVELMLCRRSDEDYMSRKDHDFRLRRQESARYLSSAQRQQINEEYMRSCQLPEDHDLRPPPPEKCKTVVILKGPYSPLECTMQCITRVGSSKRVNIDHLSVNALLLDADPQDHHDHLIVAHEIAENRNGHTLTARGTTLMPNVQGFGALMVMLFSPTMQLKCNREGTSYVSVLGGLGCDPETNEPYFPEHDVLINLDVNILEDDVILINQIRYYIDSVFFNFKDENNPAVSANERVSIYTQLRSIINRLLCKDRRYIERNMSNADFEWETHPDLPPPNEPFGKRAIFPMHSLTELQEEDTGRLVQLRENCSMLHKWRNVEGTLPHMTCKLCNQLLDSVPQLRLHLLTILHRDREKQIDYCNQ

spn-E

Probable ATP-dependent RNA helicase spindle-E

1433 amino acids

Probable ATP-binding RNA helicase which plays a central role during spermatogenesis and oogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi and govern the methylation and subsequent repression of transposons. Involved in the repression of LTR retrotransposon copia. Also involved in telomere regulation by repressing specialized telomeric retroelements HeT-A, TAHRE, and TART; Drosophila telomeres being maintained by transposition of specialized telomeric retroelements. Involved in telomeric trans-silencing, a repression mechanism by which a transposon or a transgene inserted in subtelomeric heterochromatin has the capacity to repress in trans in the female germline, a homologous transposon, or transgene located in euchromatin. Involved in the repression of testis-expressed Stellate genes by the homologous Su(Ste) repeats. Required for anteroposterior and dorsoventral axis formation during oogenesis (By similarity).

Belongs to the DEAD box helicase family. DEAH subfamily.

164.469 kDa

MDQELMDFFDFSKEFVRKQAPRGHVSSNVHAFVTESEELEKPIKREIVGKDYVKSFVEKEKERMNGIFSSDEMAPMRNKSLDDMDSDEEYEASPEIRTDAEFYEKYYFNLNRDKSLPIYAKREEIINAINENPVVIVKGETGCGKTTQVPQYILDEGFKSKQYCNIVVTQPRRIAAISIANRVCQERQWQRGTVCGYQVGLHRQLERFADTRLLYCTTGVLLNILVNNKTLTHYTHIVLDEVHERGQEMDFLLIVIRRLLATNSRHVKVILMSATINPRELSDYFANERSAPPVIDASYGRNFTVEKYYRDQLQTINWEGHQEDINSPGITQEGYRSAIKTILVIDNMERNERSTGKSYNQSLREGSILIFLPGVGEINNMSDMLKDMANHDSIMKFNMVRCHSLMSSDDQREIFQPSPPGYRKIIMATNVAESSITVPDVSYIIDFCLEKVLFTDTFTNFSSLRLVWASKTNCRQRAGRVGRLRNGRVYRMVTKSFYQRELSEYSVPEMLRSPLQNCVLKAKELKMGTPVEMLALALSPPNLSDICNTILLLKEVGALFPTVDGTYDPCDGDITYWGTIMSKLPLDTRLSRLIILGYIFNLLDEAIIIAAGLTVRGIFVDSTRLGSDNYWMHYVFADGSGSDLVGIWRVYLTYLNMCENGLQKDASIQWAKRFHLSLRALSEMNLLVLDLRLRCEKLSLLPLNFPISRISDDSEKAIMLKVIIAGSFYPNYFVQSKSTSGDDRNMFSVISGLDPCRTVYFTSFTDRTMGELYTRKVKQLFPETQIPPENMDVTFGQGSEKIFVTFKNDIYKPEGTTYVHVPGRIKAEVYKALRLRTYCNHHSLRVMEPMSALKYVKDKKIGKVVEGRWIPPSKPVAVELLALPSVFDKIIVGRITNIVSCGKFFFQPESFENCIANMSEHFNNPQQLQNCVRNAGAITKGLMLLAKRQGKYQRATVVRVDTQNSSNVRFYVRFVDYGDIERLPMTQLRLMSQDLLRHYRDLPPRLFECRLALVQPASMVSTYNAWPQKADDMLHALAKGGRVQLEIYSLVQNVAAVMIHLREGNLNELLVKEKLARRTNEDYMSRVDHDFRMRKQECRGYVSQQERQQVNEEYLRSKQLPQDMDLSPPPPQECKSLIILKGPFSTLESTVFSTMQSGMSKTVRIDPCSVNFVLLDTEPQDQHAKMVVAASISSAGRHNDVLTLRSTSIMPNIPGFAAIMTLIFCPRAQLNANTANSRYVSILAGLGYHPQTMKSYYEDHDLVINLDVNIDEHDVLLINQIRYMMDSVFFNLEGELRPIAGHADRVLIHDTIYRALNRLLSKNRNFIVCNPKSSDYVWQDMEESGEPDPQPYGRRSIFPMHTIPELHEENMDTVLDLIANCKEMYDYRNFEGSFDPMTCRLCKQYLESVSELRLHLLTQLHLDREKEVGYPMD

spn-E

Probable ATP-dependent RNA helicase spindle-E

1433 amino acids

Probable ATP-binding RNA helicase which plays a central role during spermatogenesis and oogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi and govern the methylation and subsequent repression of transposons. Involved in the repression of LTR retrotransposon copia. Also involved in telomere regulation by repressing specialized telomeric retroelements HeT-A, TAHRE, and TART; Drosophila telomeres being maintained by transposition of specialized telomeric retroelements. Involved in telomeric trans-silencing, a repression mechanism by which a transposon or a transgene inserted in subtelomeric heterochromatin has the capacity to repress in trans in the female germline, a homologous transposon, or transgene located in euchromatin. Involved in the repression of testis-expressed Stellate genes by the homologous Su(Ste) repeats. Required for anteroposterior and dorsoventral axis formation during oogenesis (By similarity).

Belongs to the DEAD box helicase family. DEAH subfamily.

165.312 kDa

MDSDLMDFFDFSKQFKRGTALKGCITGDPNALTTESRDSKPIKREKIGTDYVNEIVEKEKQLMNKLVDGQSVAKRNRTLDELDSDDEEENMQEQPSVRSDEAYYEKYRFDLNRNKNLPIYAQREQIMKAIRENPVVILKGETGCGKTTQVPQYILDEACKRREFCNIVVTQPRRIAAISIANRVCQERQWQPGTVCSYQVGLHRQSNVEDTRLLYCTTGVLLNNLIRLKTLTHYTHIVLDEVHERDQDMDFLLIVVRRLLALNSRHVKVILMSATIDTREFSKYFATSSAFPPVVTASHGRKYPLVKYYRDQLKNIHWKDEPQERAPGIGPEGYADAIKILLVIDNMERKAVGQSLQSYEEAKRTGSVLIFLPGINEIDTMADHITSVMEENPTMIITIVRCHSLMSPDSQEEVFQPPLPGHRKIILTTNIAESSITVPDVSYVIDFCLTKVLHTDTATNYSCLRLEWASKVNCRQRAGRVGRLRSGRVYRMVSKAFYLEEMKEFGIPEMLRSPLQNSVLKAKELEMGRPSEILALAMSPPNLSDIQNTVLLLKEVGALYTTVDGVYEELDGDLTYWGTIMSRFPLDVRLSRLIILGYVFNCLEEVIVIAAGMTVRSLYLTGKRRQVNDAFWMHYIFADGSGSDMVAIWRVYRIYLNMCQDRMLKESAEQWARRFNVNLRSLKEMHLMVQELRQRCASVNLQPLPYGTCQMWDDREKSIILKVIIAGAFYPNYFMRSNKSNADYDRSLFQSICGNDPCRTVFFTHYEPRYMGELYTRRIKELFLEVKIPPENMDVTFLHGSEKVFVTFKSDDEDMDTAKVVQVPGRVMTEVYKAVRMRLENQNRPLRVMDQNSALRYVQDRKIGVVTEGTWFPPSNQWNVELLTLPSVFAKNITGLVTYIVSCGKFYFQPRALAESIASMSEIFNGPQQLSCHVRNASAVTKGLQLLAKRGHLFQRAVVLRIETQTNGHPRFRVRFIDYGDMAVLPMDQLRLMPHELKRDFDQLPPRMFECRLALVQPSMVTSSYNRWPKAANDMLISVAQCGRLELEVYSLVNNVAAVLIHMRDGVLNDRLVERQLARRADEDYMSRKDHDLRIRKQEAKRNISVAEQERINEEYLRFAQLPKDMDLEPPPLDKCNLSIRLRGPFSPLESSMNSMLRIGMYKSVTIDKDSVNAVLLDTDPQDRHDQMVVAASVTETDNTERLTARGTTLMPNIHGFGALMAMLFCPTMQIKCNKDRTKYVCLLAGLGFDPETLEPYFAEHDMVINLDVTILRDDIRIINQMRYNIDSMFYNFDANEMPSVGTEDRVVIFNQLRSLLTRLLGKDRSFIERHVSNSEYLWEDMSDLEPPSEPYGKRAIFPMHSSYDLENDNLSNLLELQANCKQLYDWRNFEGNLQTQVCRLCNESLESVAELRLHLLTQLHRDREKQVGYKQQ

spn-E

Probable ATP-dependent RNA helicase spindle-E

1432 amino acids

Probable ATP-binding RNA helicase which plays a central role during spermatogenesis and oogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi and govern the methylation and subsequent repression of transposons. Involved in the repression of LTR retrotransposon copia. Also involved in telomere regulation by repressing specialized telomeric retroelements HeT-A, TAHRE, and TART; Drosophila telomeres being maintained by transposition of specialized telomeric retroelements. Involved in telomeric trans-silencing, a repression mechanism by which a transposon or a transgene inserted in subtelomeric heterochromatin has the capacity to repress in trans in the female germline, a homologous transposon, or transgene located in euchromatin. Involved in the repression of testis-expressed Stellate genes by the homologous Su(Ste) repeats. Required for anteroposterior and dorsoventral axis formation during oogenesis (By similarity).

Belongs to the DEAD box helicase family. DEAH subfamily.

164.345 kDa

MDQEVMDFFDFSKEFKREAAPQGYISSDPSIMATETNESKVPKREVIGTDYVPEIVAKEKCLLDRTLRDDCPQSKRNRTLDDLDTDDEGEETEIRRDDEYYKRYRFNLNRDKNLPIYAKREEILAAINAHPVVILKGQTGCGKTTQVPQYILDEGYKSGKYCNIVVTQPRRIAAISIANRVCQEREWQQDTVCSYQVGLHRPTSLEDTRLLYCTTGVLLNNLINKKTLTHYTHIVLDEVHERDQDMDFLLIVVRRLLATNSRHVKIILMSATIDARELADYFTTTNSVPPVITASHGRKHAIEKFYRDQMGSIRWKEEEDDQLVPQINDHGYRAAVKIIMVIDNMEREAAIQSRLSYDEALRYGAVLIFLPGIDEIDTMAENITSMLQSDRNIKVFIVRCFSLMTPENQRDVFHPPPPGFRKIILTTNIAESSITVPDVSYVIDFCLTKVLVTDTATSFSSLRLTWASKANCRQRAGRVGRLRSGRVYRMVNKSFYQREMAEFGIPEMLRMPLQNSVLRAKELEMGSPIEILALALSPPNLSDIQNTILLLKEVGALFLTVDGVYNAMDGDITYWGTIMSRLPLDTRLSRLIILGYVFNLLEEAIIIAAGLSMRGLYVNEGRRTQGADSFWMHYIFADGSGSDLVAIWRVYLTYLNMVEIAHEQESAIRWAKRFHVSLRSLKEMHLLVQELRWRCTNLGLIPFAVNPSQMMGDREKSIILKVIIAGAFYPNYFTRSKESCAEPDRNIYQTISGHDPCRTVYFTNFKPAYMGELYTRRIKELFQEARIPPENIDVTFQQGSQKVFVTFKQDDWLADSSKFVSVSGRVQSEVYKAVRMRLDRIQRPIRIMTQNNFMNYVQQRGIGDVIEGRWIPPTKPLNVELLALPSVFSKTITGLITCIISCGKFFFQPQSFAECIRNMSEIFNAPQQLRNYVINAGAITKGMMVLAKRDSNFQRATVIRPENQSNRQPMFYVRFIDYGDCALLSMQQLRLMPKELIQQYGDLPPRVFECRLAHVQPSSVVSGNNRWPTAANDLLKSVAKCGRIDIEVYSLFNNVAAVLIPMKDGIINDMLVELKLSRRSDEDYMSRKDHDFRLRRQESARYLTLTERQQINEEYLRSCQLPQDLDLPPPPLDKCNTIVMLKGPSSPLECSMQSIIRVGSSKRVNIDNASVNAVLLDADPQDHHDHLIVAHATVESTNGQTLTARGTTLMPNVQGFGALMVMLFCPTMQLKCNNEGTSYVSILAGLGCDPVTGEPYYAEHDVLINLDVNILEDDVVLINQIRYYIDSVFFNFKEEKDPAVSINERVSIYTQLRSLINRLLCKDRSYMQRNMSNSDFEWESNPELPMPNEPFGKRAIFPMHSLTELQEEDMGRLMHLRENCSMLHKWRNFEGTLPHMTCKLCNQLLESVPQLRLHLLTVLHRDREKQIDYCNQ

spn-E

Probable ATP-dependent RNA helicase spindle-E

1432 amino acids

Probable ATP-binding RNA helicase which plays a central role during spermatogenesis and oogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi and govern the methylation and subsequent repression of transposons. Involved in the repression of LTR retrotransposon copia. Also involved in telomere regulation by repressing specialized telomeric retroelements HeT-A, TAHRE, and TART; Drosophila telomeres being maintained by transposition of specialized telomeric retroelements. Involved in telomeric trans-silencing, a repression mechanism by which a transposon or a transgene inserted in subtelomeric heterochromatin has the capacity to repress in trans in the female germline, a homologous transposon, or transgene located in euchromatin. Involved in the repression of testis-expressed Stellate genes by the homologous Su(Ste) repeats. Required for anteroposterior and dorsoventral axis formation during oogenesis (By similarity).

Belongs to the DEAD box helicase family. DEAH subfamily.

164.853 kDa

MDEDLMGFFDFSKEFKRTEAPKGCISSNFVGLGTEKEKTKPPKQENLGTEYVKEIVDREKQNLESLGIGGSAAKRNRTLDDIDSDNEECYEAPDLRLDEEFYSKYYFDLNRDKTLPIYTQRDQIMKAIRENTVVILKGETGCGKTTQVPQYIIDEAYQNRQYCNIVVTQPRRIAAISIANRVSQERHWEPGTVCSYQVGLHRQSGSEDARLLYCTTGVLLNFLINHKTLTHYTHIVLDEVHERDQEMDFLLIVVRRLLATNSRHVKVILMSATIDSREFVQYFATKNGIPPVINASHGRKYPLVKFYRDQLKNMQWQEDQPNPDEPGMGSHGYSAAIKILLVIDNMERRTEGQSQRSYEENLKTGSVLIFLPGINEIDNMAESIDHVMQENPALKVSIIRCHSLMTPDSQRDVFASPPVGYRKIILTTNIAESSITVPDVSYVIDFCLAKVLVTDTATNFSSLRLVWASKSNCRQRAGRVGRLRSGRVYRMVPKSFYMKHMLEFGVPEMLRSPLESSVLKAKELNMGPPIEMLALALSPPKLSDIRNTILLLKEVGALYPTVDGNYVELDGDLTPWGSIMTRLPLDIRLSRLVLLGYVFNCLDEAIVMAAGLSVRGLYLQEAGFQSYEAYWMHYVFADGSSSDLVAIWRFYKTYLNMCENRIMQESAAQWARRYHISLRSLKEMHLLVQELQYRCNKLRLHPVQLQSCQIKDDRERALILKILIAGAFYPNYFIRSNKFNPDYGRNTYQVLGGYDPCRTVYFTHFEPRYMGELYTRRIKDLFSEAKIPPENMDVNFQVGSEKIFVTFKQTEDEMDQLNLIQVPGRILTDVYKAVRLRIGKQYRPIRVMELPHAIQYVQENKIGTVIEGQWHPPSKPFNAGLMALPSVYDKNMIGYITHIVSCGKFFFQPLELADSITNMSEHINSPKNLSHYVVDAGSITKNLKLLAKRVDDFQRAQVIRVETHSHQYPKFRVRFIDYGDIAVVPMDQLRFMSNQLKREYDDLPPRCFECRLALVQPAALTSNYNRWPIKANEMVRKIAMDGRVEMEIYSLVNNVAAVFIKMREGVLNDKLVEKNYARRSDEDFASIQDHDFRLRKQERSFHVPRAERKQVNEEYLRVSRLPQDADLSPPPMHKCQTVVRLKGPYSPLEASMFSTIRASACKTVRIDPLSVNSVLLDSNPQDRHDQLIVSASVTTSNNNQVLTVRGSTVMPNTHGFGALMALIFCPTVQIKCNKECTKFVSLLAGLGYNPETMEPYYEDHDVVMNLDVNLLEDDVRLINQMRYNIDTIFFKYEGEDAPAVSEGDRSIVFNQLRCLLSRLLSKDRCYIEPHSSNLDNVWEKLDNLEPQSEPYGKRAIFPMHTIPELQNEDTTARLVLQENCKRLYSWRTFDGVLQPLDCKLCNQRLETVSQLRLHLLSQLHRDREKQIGFQDN

spn-E

Probable ATP-dependent RNA helicase spindle-E

1431 amino acids

Probable ATP-binding RNA helicase which plays a central role during spermatogenesis and oogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi and govern the methylation and subsequent repression of transposons. Involved in the repression of LTR retrotransposon copia. Also involved in telomere regulation by repressing specialized telomeric retroelements HeT-A, TAHRE, and TART; Drosophila telomeres being maintained by transposition of specialized telomeric retroelements. Involved in telomeric trans-silencing, a repression mechanism by which a transposon or a transgene inserted in subtelomeric heterochromatin has the capacity to repress in trans in the female germline, a homologous transposon, or transgene located in euchromatin. Involved in the repression of testis-expressed Stellate genes by the homologous Su(Ste) repeats. Required for anteroposterior and dorsoventral axis formation during oogenesis (By similarity).

Belongs to the DEAD box helicase family. DEAH subfamily.

165 kDa

MDSDLMDFFDFSKQFSRAPAPKGYITGDPTAFATETIDSKPIKRELIGKDYVHEVVEKEKHLMKKLADGYNTSKNRRTLDELDSDDDEVLMKELPSVRSDEEYYKKYRFDLNRNKNLPIYEQREDILAAIRENPVVILKGETGCGKTTQVPQYILDEAFKRREFCNIVVTQPRRIAAISIANRVCHERKWQPGTVCSYQVGLHRQSNLEDTRLLYCTTGVLLNNLVRVKTLTQYTHIILDEVHERDQDMDFLLLVVRRLLALNSRHVKVILMSATIDTREFSKYFAMSSSLPPVVTASHGRKFPLVKFYRDQLKNIHWKDEPQRTTPGIGPEGYSDAIKLLLVIDNMERKADNQSQQSYEEAKRTGAVLIFLPGIHEIDTMAEHIGRIVDENPNFKISIVRCHSLMSPDSQEEVFLPPPLGHRKVILTTNISESSITVPDVSYVIDFCLTKVLHTDTASNFSSLRLEWASKVNCRQRAGRVGRLRSGRVYRMVTKDFYMNHMNEFGIPEMLRSPLQNSVLKAKELEMGNPSEILALAMSPPNLSDIQNTVLLLKEVGALYTTVDGVYEELDGDLSFWGKIMSKFPLDVRLSRLIILGYVFNCLDEAIVIAAGMTVRSLYVTGSRGQMNEAFWMHYIFADGSGSDMIGIWRVYRIYLNMCQDRMLKESAQQWARRFNVNLRSLKEMHLMVQDLRQRCASLNIQPLPYGACHMWDDREKSIILKVIIAGAFYPNYFMRSNKANADYDRSLFQTICGNDPCRTVYFTNFEPRYMGELYTRRIKELFLEAKIPPENIDVTFQHGSEKVFVTFKPDDEDIDTTKVVQVPGRVMTEVYKAVRMRLENQNRPLRVMDQNSAFKYVEQNRIGVISDCTWVPPSNQWPVELLTLPSVFDKTIFGLITHVANCGKFYFQPQALAERIASMSEIFNRSLELSCYVQNAKAVTKGLQLLAKRGNLYQRAVVLKVETQINGYPRFRVRFIDYGDVAVVPIDKLRLMSPQLKRDFERLPPRMFECRLALVQPSSVASSYNQWPQHANEMLISVAKSGRVELEIYSLVNNVAAVLIHTRGGVLNDMLVDRQLARRADEDYMSRKDHDLRLRKQETKRNVSITDQRLINEEYLRFAQLPKDTDLEPPPLNKCNLSIRLKGPYSPLEASLNSLLRIGMYKSVYIDKESVNSVLLDSDPQDRHDQMVVAASVTEAFDNLTVRGTTLMPNIHGFGALMAMLFCPTMQIKCNKDRTKYVSILAGLGYNPDTMQPHFEEHDMVINLDVAILKDDIRIINQMRYNIDSMFYNFDVNEMPSVGTEDRVVIFNQLRSLLIRLLGKDRSFIERHVSNFEYLWEDMSDLEPPSEPYGKRAIFPMHSSYDFESENMGNLLSLQANCKELYSWRNFEGTMQPMKCRLCNDTLESVAELRLHLLTQLHRDREKQVGWKQN

spn-E

Probable ATP-dependent RNA helicase spindle-E

1429 amino acids

Probable ATP-binding RNA helicase which plays a central role during spermatogenesis and oogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi and govern the methylation and subsequent repression of transposons. Involved in the repression of LTR retrotransposon copia. Also involved in telomere regulation by repressing specialized telomeric retroelements HeT-A, TAHRE, and TART; Drosophila telomeres being maintained by transposition of specialized telomeric retroelements. Involved in telomeric trans-silencing, a repression mechanism by which a transposon or a transgene inserted in subtelomeric heterochromatin has the capacity to repress in trans in the female germline, a homologous transposon, or transgene located in euchromatin. Involved in the repression of testis-expressed Stellate genes by the homologous Su(Ste) repeats. Required for anteroposterior and dorsoventral axis formation during oogenesis (By similarity).

Belongs to the DEAD box helicase family. DEAH subfamily.

164.179 kDa

MDFFDFTKDFRREEAPSGFISSDPSSMATEMFESKPIKREVIGTDYVAEIAAKEKLLMSGQLKAEIPGQYSGGMDDLDSNDDMDDEEISKIRLDEEYYKKYRFNLNRDKNLPIYAKREVIVNAINTHQVVILKGETGCGKTTQVPQYILDEGFKSGQYCNIVVTQPRRIGAISIANRVSQERMWEPDTVCSYQVGLHRKQHLEDTRLLYCTTGVLLNSLIRNKTLTHYTHIVLDEVHERDQDMDFLLIVVRRLLATNSRHVKVILMSATIDTREFCDYFSTKVSVPPVISASHGRKHSIEKFYRDQLGSINWKDDPDDGYQARIPDEAYKAAVKIILVVDNMERQAANQSEQSYDDAKSQGAVLIFLPGIYEIDNMAESLGNMTKEEPSMKLFIVRCFSLMTPDAQRDVFSPPPSGFRKIILATNIAESSITVPDVSYVIDFCLTKVLVTDTATNFSSLRLTWASKANCRQRAGRVGRLRSGRVYRMVHKLFYKTNMTEFGVPEMLRLPLQNSVLKAKLLDIAPPIEMLALALSPPNLSDIQNTILLLKEVGALFPTVDGEYCEVDGDITFWGIIMSRLPLDTRLSRLIILGYVFNLLEEAIVIAAGLSMRGLSTEAGRGRLTSDAYWMNYVFADGSGSDLVAIWRIYRTYENMVANGMHQESAEPWARRYHVSLRALKEMHLLVQELKSRCSQLGMISFNLSSSDMPDDLEKAILLKVIIAGAFYPNYFLRSKKTTLEQERDIFHVISGRDPCRTVYFTNFKPAYMGELYTRRIKDLFQELKIPPESIEVTFQPGSQKVFVTFKSDECDTNCTRLINVPGQVLTEVYKSIRMRLYQSNRTFRVMDHNNALNYVQRHGIGTLKEGHWTPPSRPLNVEMLALPSVYEKNMTGLITHVDHCGKFFFQPKSFARCIQNMSEIINTPMHLQYEIQNAGVLTKGMMVLAKRKGTFERAIIVRPETQNNRQPKFFVRFVDYGNTDLMYIEQLRLMTKELLSQYGDLPPRVFECRLALVQPSTMSNTLSRWSRDAKDMLISASKNNIVEIEIYSLVYNVAAVMVHTRDGLLNDKLVEHNLARRADENFMSRQDHDFRIRKQESARYISGPERQQVNEEYLRSCQMPEDLDLTPPPLDKCNMIVMLKGPYSPLETSMFSTIRVGVWKTVKIDNSSVNAVLLDSDPQDNHDQLVVSHSTVESSNGDVLTARGTTLMPNIHGFGPLMTMLFCPTMQIKCNKDCTKYVSILAGLGFDKETMKPYFEEHDMVMNLDVNLYEDDVRMINQMRYNIDTMFFNFEGEELPSLNMNDRVTIYKELRKLVNRLLSKDRSYIELNASNSDFNWEKEDRIEPQPEPFGKRCIFPMHVIPELLEEDIGRRLYLIDNCKKLYKWRNFEGALDILNCKLCNMSLETTPQLRLHLLTQLHRDREKQIGFKNE

spn-E

Probable ATP-dependent RNA helicase spindle-E

1396 amino acids

Probable ATP-binding RNA helicase which plays a central role during gametogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons (By similarity).

Belongs to the DEAD box helicase family. DEAH subfamily.

158.391 kDa

MDEAAGPSTSRTSNLEDVDDEGASLAEEDEEHTKALKAKEMMAPLFQRYNFTMKKNDLPINWNKPEILDKIRSNAVVVLQGATGCGKTTQVPQYLLEEAFERKEYCNIIVTQPRKIAAISIARRVAQERKCDLGTLVGYKVGLKEQHNEDTRLLYVTTGVLLQSLINSKTMATYTHVILDEVHEREVDMDFLLIVVRRLLSTNSKKTKVILMSATIDAKGFSEYFKIPKKSGYLSAPVISVERPRLHVVQEFYFDDLEKLKVDFQIDYEAPGISEQMYNIAAKLVVVCDHLKGQEFGDSLEYKPSIIIFLPGINEIEKMEGALEKLIASIQNAAQRPNLLIMKLHSTLPADDQTAVFRKPGPNQRKVILSTNIAESSITVPDIKFVIDFCLQRILVTDTLTNFSTLRTEWASKSNCIQRAGRAGRLMSGRVYRLVDRRFFENNMDVSTSPEILRCPLETVVLKAKLLEMGTPPSILALAMAPPNLDDIRNTILLLKEVGAMLRTVKGNYDQLDGDLTYLGRIMSKLPLDIRISKLIMLGYIFSVMEEAVTIGAGMNVKNIFLNQNSVKTYSQKMYWADGSGSDAIAILNAYTAWKSRQEQAGDTADMYNWARRMSLDRKSLIDMAELIHEVKDRLNRSGLKPVSGPNRVVWNAREKTVILKVILAGAFYPNYFIPMSVGGKELMERQSFTELGGRDPCNTVFFTGFDHERYIGPLYTVQIKKILSEGDYSKHQAMKVMYDRTTNRIFVTFLGTTDERDQRGSFMPGKVHADVYRAIKLRKLGARNRITEIRTMRQRDAIDYATSAGLGHWEDANGWVPRRKIVRNAHLSVLPPIFREKVVCQVTHVVHPNKFFLRPEDNRNKDIFREIHTQLNARQLHPFPADANFAMGQMVAAPVQENQETYARAVLRSYRNVRTTGSVSWTVFFIDYGHTAAMEETAFRQLDDSLGQLKDIPPRAFEATLTEIQPSAIISPQGSWTTESIHRFKELVLGKIFVAKVYSVVGVVASVELSRDEIRMNSELIRLKYAQYAEESYISKLDHDHRERKQREIMMDENLRNEVYRSAELTQNTYEDDELEDVNPPEDKLRCKVVLSGPHSPLETSASATIRSSVMKPVSIESDSVNSILLDSNPQDTHEKLLVAGGVNEQGNRLVLRQTSVMPNIPGFGAIMSLIFCPTAQLKKDKDETRVVTVLSGLGYDPSTGEALYPEHDMALTLDVVLNDDDITNINALRYTMDSILHTGEGQTDPKFGDASIQKLKLQVKQYIIKILEHERRFLDLRHAPNDYNWRCDLNLTAGSSSSKKMKGDFNIYDKKAIFPLLEPLNLLPVSASQLTFLKKHCHELHKLAHTDVQLPRHGITCQLCNNVLETLPQLRIHLYSKLHRDRESQIKYRSPQMY

spn-E

Probable ATP-dependent RNA helicase spindle-E

1374 amino acids

Probable ATP-binding RNA helicase which plays a central role during gametogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons (By similarity).

Belongs to the DEAD box helicase family. DEAH subfamily.

157.427 kDa

MSMADEDEEHTKALKAKEMMLPLFQKYNFTLKHNKLPIRHSKDDILARIRENPVIVLEGPTGCGKTTQVPQFILEEAYHRKEYCNIIVTQPRKIAAMSIAKRVSEERKCELGTLVGFKVGLKECLSPDTRLLYCTTGVLLQSLINSKTMANYTHVILDEIHEREVDMDFLLIVVRRFLATNSSKTKVILMSATIDSKAFAEYFKTPKKVGYLTAPIISVDRPRLYEVKEFYYDDLDKLRLDFAIDYENPGISSHMYTVAAKLVLVCDRLIENMHGEERMEYKPTVLIFLPGINEIDRMDHVLRETLTRIVNPKEKPNLDIHRLHSILPADEQVKVFRKPAPGQRKVILSTNIAESSITVPDVKFIIDFCLQRVLFTDTTTNFSTLRTEWASQANCIQRQGRAGRVMDGRVYRLVDRRFYENQMRFSTSPEILRCPLENVILKAKLLEMGPPHSILALAMNPPDLSDIRNTVLQLKELGALVQTVKGNYEQLDGDLTYMGRIMAKLPLDLRISKLIILGYIFSVLEESIIIAAGMNEKNIFLNQNSVRGYSQKMYWADGSGSDGIAILNAYIAWKSRKEQAGNESDMASWTRRMSLDLKCLMDMAELIREIKDRLNHVGMKEVSGPGRVVWSSREKTVILKVIMAGAFYPNYFIPMSVGGKELMERQSFTELGGRDPCNTVFFTGFDHEKYIGPLYTVQIKKLLSEGDFSKHQNMKVMYDRTTNRIFVTFLGSNDEHDQRGAFMPGKVHADVYRAIKLRKLGSRNRIMEIRTMRQRDAIEFATEMNLGHWEDANGWVPRRKVIRNAHLSVIPAIHQASMVCQVTNVIHCNKFYLRPEDTKNKDIFMDIHSKLNSRGYRLERFDPDWQFAVGQMVAAPLEEGSDRYARAVLKNYKNIRSTGDVMWTVFFLDYGHSSVLGQSAFRKLDGPLAYMKEIPQRVFEATLSEIQPSAIISPQGIWTAQSINRFKEMTLGKIFVVDVYSVVNDVASVVLKKGDEVPINSELIRLKFAQYAEESYISKLDHDMRERKQREMSLDEDVRYEVYHSSKNNQLKYEEDELEDVSPPEEKLRCKVMLSGPHSPLETTASSTVRSGVMKPVTIENDSVNSILLDSNPQDTHEKMLVGAFVHEQGNRLVVRQASMMPNIPGFGPLMALIFCPTCQMKKDEEETRVVSILTGLGCDKNTGESLFPEHDLALTLDVVLSDDDITEINALRYTMDTILHTDQDQTVPKFGDVSIENLKAKVKQYIIKILEHERKFMDIRHAPNDYDWKLVEENNAAEASSSSKKRKQDFNIYDNAIYPLLPPLGLLPVSAKQLDFLKRHCRELHKLALTDVNLPRHGITCQMCNTILETLPQLRIHLYSKLHRDRESQIKFR