sph

Oleate hydratase

590 amino acids

Catalyzes the hydration of oleate at its cis-9-double bond to yield 10-hydroxyoctadecanoate, and of linoleate at its cis-9- and cis-12-double bond to yield 10-hydroxy-12-octadecenoate and 10,13-dihydroxyoctadecanoate. Is not active on trans-double bonds and esterified fatty acids as substrate; is only active on cis-9- and/or cis-12-double bond of C16 and C18 fatty acids without any trans-configurations, producing 10-hydroxy and 10,13-dihydroxy derivatives. Appears to play a role in oleic acid detoxification and bacterial virulence.

Belongs to the oleate hydratase family.

67.408 kDa

MYYTSGNYEAFATPRKPEGVDQKSAYIVGTGLAGLAAAVFLIRDGHMAGERIHLFEELPLAGGSLDGIEKPHLGFVTRGGREMENHFECMWDMYRSIPSLEIPGASYLDEFYWLDKDDPNSSNCRLIHKRGNRVDDDGQYTLGKQSKELIHLIMKTEESLGDQTIEEFFSEDFFKSNFWVYWATMFAFEKWHSAVEMRRYAMRFIHHIDGLPDFTSLKFNKYNQYDSMVKPIIAYLESHDVDIQFDTKVTDIQVEQTAGKKVAKTIHMTVSGEAKAIELTPDDLVFVTNGSITESSTYGSHHEVAKPTKALGGSWNLWENLAAQSDDFGHPKVFYQDLPAESWFVSATATIKHPAIEPYIERLTHRDLHDGKVNTGGIITITDSNWMMSFAIHRQPHFKEQKENETTVWIYGLYSNSEGNYVHKKIEECTGQEITEEWLYHLGVPVDKIKDLASQEYINTVPVYMPYITSYFMPRVKGDRPKVIPDGSVNLAFIGNFAESPSRDTVFTTEYSIRTAMEAVYSFLNGERGIPQGFNSAYDIRELLKAFYYLNDKKAIKDMDLPIPALIEKIGHKKIKDTFIEELLKDANLM

sph

Sphingomyelinase C

556 amino acids

63.269 kDa

MRIKKYTKVRLLVNCCLLLFFLIDCGADRQSLYKDLLASLIYISDNKNIGSTNSDLTGSGSVSSSPADAAPENSILANSIPENMGIKILTHNVFLLPKTLPGWGNWGQNERAQRIVSSNYIQNQDVIVFDEAFDTDARKILLDGVRSEYPYQTDVIGRTKKGWDATLGLYRTDAFTNGGVVIVSKWPIEEKIQHVFKEKGCGADVFSNKGFAYVRIDKNGRKFHIIGTHVQAQDSGCANLGVVSRVNQFNEIRDFIDSKKIPKNEMVLIAGDLNVIKGSREYHQMLCILNVNNPKYVGVPFTWDTKTNEIAAFYYKKVEPAYLDYIFVSKSHFQPPIWQNLAYDPISAKTWTAKGYTSDEFSDHYPVYGFIYADSSTPTKSGRKRKYDRVSFVSVATGKKIQANSEKSNAWLKVNATTETDLTKFNLVQTNDPDSNPSCMKSGHVRIESSHSLNYFWNWWLGGGKGNYAYYPKFNDGSNRIQIINLDGGCLQDGSRVAFKDYDTISRRQYFLTVWEGGNWDKYLYLWRSHIGLREIFYLKLDSSPEMNWSKKLIYR

SPH

Sphingomyelin phosphodiesterase D

364 amino acids

Catalyzes the hydrolysis of sphingomyelin.

Belongs to the arthropod phospholipase D family.

41.567 kDa

MIRIFALITALAITVKCQDDRRPFYVIGHMVNSIPQVSQFLELGTNAIESDVEFSENGTALRTFHGLPCDCLRRCKESADIVDYFQYIRNVTGFRHSEYSEKLLLVFLDLKVSKLPPESKYAAGVDIATKLVLHLWDGVPFYDAMNVLLSIGRASDMAVLTGAIDTIIGFDPSLSLFNHVGFDVGLNDKLENIAKMYERLGVNGHRWQGDGITNCLVNLRSPLRLKETISYRDTNKRESYVDKVYYWTVDKVATIRKTIRRGVDAIITNRPKRVTGVLEEDEFKKTVRPATYRDDPWMRLQSKTTGRGNELDSDMDEMGDEASEFDFEPFSYPLSPRRPLSSRSPAIRDSYNVWPQYNPLSPFY

SPH

Spindolin

341 amino acids

This protein is a spindle body protein.

38.709 kDa

MNKLILISLIASLYQVEVDAHGYMTFPIARQRRCSAAGGNWYPVGGGGIQDPMCRAAYQNVFNKVLNSNGGDVIDASEAANYMYTQDNEYAALAGPDYTNICHIQQRVVPSYLCAAGASDWSIRPFGDKSGMDLPGSWTPTIIQLSDNQQSNVVMELEFCPTAVHDPSYYEVYITNPSFNVYTDNVVWANLDLIYNNTVTLRPKLPESTCAANSMVYRFEVSIPVRPSQFVLYVRWQRIDPVGEGFYNCVDMKFKYSEGPDEEDIIEPEYEVDNEAECFAYRTNSGNVNVNPLQENKYMAYANKAIRNINTHSNGCSRNRNNKNNYNKYYSKTYNYNQNRK

sph

Sphingomyelinase C

333 amino acids

Required, with sphingomyelinase, to effect target cell lysis (hemolysis).

Belongs to the neutral sphingomyelinase family.

36.949 kDa

MKGKLLKGVLSFGIGLGVLYGGSSVQADTSTDQNNTLKVMTHNVYMLSTNLYPNWGQSQRADLIGAADYIKNQDVVILNEVFDNSASDRLLGNLKKEYPNQTAVLGRSNGNEWDKTLGSYSSSTPEDGGVAIVSKWPIVEKIQYVFAKGCGPDNLSNKGFVYTKIKKNDRFVHVIGTHLQAEDSMCGKTSPASVRTNQLKEIQDFIKNKNIPNDEYVLFGGDMNVNKINAENNSDSEYASMFKTLHASIPSYTGHTATWDATTNSIAKYNFPDSPAEYLDYIIASKDHANPSFIENKVLQPKSPQWTVTSWLKKYTYDDYSDHYPVAATISMK

sph

Sphingomyelinase C

333 amino acids

Required, with sphingomyelinase, to effect target cell lysis (hemolysis).

Belongs to the neutral sphingomyelinase family.

36.873 kDa

MKGKLLKGVLSLGVGLGALYSGTSAQAEASTNQNDTLKVMTHNVYMLSTNLYPNWGQTERADLIGAADYIKNQDVVILNEVFDNSASDRLLGNLKKEYPNQTAVLGRSSGSEWDKTLGNYSSSTPEDGGVAIVSKWPIAEKIQYVFAKGCGPDNLSNKGFVYTKIKKNDRFVHVIGTHLQAEDSMCGKTSPASVRTNQLKEIQDFIKNKNIPNNEYVLIGGDMNVNKINAENNNDSEYASMFKTLNASVPSYTGHTATWDATTNSIAKYNFPDSPAEYLDYIIASKDHANPSYIENKVLQPKSPQWTVTSWFQKYTYNDYSDDYPVEATISMK

sph

Streptomycin 6-kinase

307 amino acids

The aminoglycoside phosphotransferases achieve inactivation of their antibiotic substrates by phosphorylation.

Belongs to the aminoglycoside phosphotransferase family.

33.154 kDa

MSTSKLVEIPEPLAASYARAFGEEGQAWIAALPALVEELLDRWELTADGASASGEASLVLPVLRTDGTRAVLKLQLPREETSAAITGLRTWNGHGVVRLLDHDPRSSTMLLERLDASRTLASVEDDDAAMGVLAGLLARLVSVPAPRGLRGLGDIAGAMLEEVPRAVAALADPADRRLLNDWASAVAELVGEPGDRMLHWDLHYGNVLAAEREPWLAIDPEPLAGDPGFDLWPALDSRWDDIVAQRDVVRVVRRRFDLLTEVLGLDRARAAGWTYGRLLQNALWDIEDGSAALDPAAVTLAQALRGH