Protein
Speedy protein 1-B
Function
Stimulates oocyte maturation by promoting meiotic G2/M progression in resting oocytes, via activation of the MAPK cascade and cdc2-cyclin B. Also activates the kinase activity of cdk2; this activation does not appear necessary for oocyte maturation. Necessary for polyadenylation in oocytes.
Similarity
Belongs to the Speedy/Ringo family.
Sequence
MRHMQSATRATLVCGSGVKQIIAKGHPNTRVFGARKARIPEREVLAAKPKITRITHLNLQPQERQAFYRLLENELIQEFLSMDSCLKISDKYLIAMVLAYFKRAGLYTGEYTTMNFFVALYLANDMEEDEEDYKYEIFPWALGDSWREFFPQFLRLRDNFWAKMNYRAVVSRRCCDEVMAKDPTHWAWLRDRPIHHSGALRGYLRNEDDFFPRGPGLTPASCALCHKASVCDSGGVAHDNSSPEQEIFHYTNREWSQELLILPPELLLDPESTYDIHIFQEPLVGLEPDGAALEWHHL