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spdl1-a

Gene
spdl1-a
Protein
Protein Spindly-A
Organism
Xenopus laevis
Length
611 amino acids
Function
Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex.
Similarity
Belongs to the Spindly family.
Mass
70.573 kDa
Sequence
MEESETVLKLRRQLKEAEEERVKAAHYGLELLESQSDLQNQLEEQRNEMTGTIENLEQEKYSLQREVELKNRMLESVTSECENIRQQQKLILEQLQEQLERNHHRELGEIKDKLEKLKAELDEARLSEKQLKHKLEYQTEVLANKSEELRMMSERVHETMSSEMLTLQLEKTELESAKANLEQEVNELQYREQQLLLTNGTQSRKLEHLQTEKEEREKESVGYFSALEKAREANQDLQAQLDIALQQAQDPNSKGNSLFSEVEDRRAEMERQLISMKVQFQSLQKQHAFSRQQMHRMKVQIATLLQMKGSQSDPEQLERLQAMVAQKNSEIEALVMKVRQLEKSQQVSENGPAVGSSDNLGQGDETYYVDLLKMKLLNSSKENEKIKDELSLQRMKALAESQRVLELERKLFANDRHLKLSQGENMKLRVSLDEIKMKYEPDEMGKIHTQKRRKEQLPLDFPMDNTSAAVTSGTEAQGLYDATAGETCTAESTDGRIHSKEDLSLSTKEQDPSSVAVKPKELPNGPPPKERKRVRIMEDENNAQDLNKRNTHNCSVTSASPRSTSEDATSESKRFDEEQEKRKQERKSRLRAPPVLHVPSKPNATTQCPQQ