spata2

Spermatogenesis-associated protein 2

550 amino acids

Bridging factor that mediates the recruitment of cyld to the LUBAC complex, thereby regulating TNF-alpha-induced necroptosis. Required to activate the 'Met-1'- (linear) and 'Lys-63'-linked deubiquitinase activities of cyld.

Belongs to the SPATA2 family.

60.648 kDa

MDAKLREDLFRRYVASLENRLEEGAAEGGGDRQGAKTEEALISTATALLGSYQADPGQRFRMLRFYDVVENSLRTQRGTSLRTVGTAFATLETICTNLLLFPWKKEYRCIKTFTGPYVYQLQSVLCDSDLRSLLRSMGYSREQELQYNVRDHPGGASHLRQLAFELLLAQAECRLLGEVVSMSRGFASELEAVELRRNTREDAAGCADALRRRDSLTGDLSRLSVRPLDIDRAHLRRSGRPSKSVDVTDSAGHWHQASKPVLKASLSLRKEPLFVDTEEDMKDEIIRPSPSLYPVAAPPSYSPVADFFPIQSPPSEPYSYHLSSLDEVDLYTERGLGGHQTPSRPPSREPRDSWVLKGHMMKCQGCGMGCPSLSSCQRCDMILCSSCHAVDPAPCCGFQDYTKTSRPLDGYMPIKEKLSVYSSAHSHTHPHPHPLPHAQSHSLLLDKAVMSSKLFPSKPVGSGPSPVGSLVSSGSSSSGGERLSVGGSRCGFCNKPGASHTCVNCSKVSCDTCMSLYASDLCTRKNPHHNFVPNHQLNFKSSTISHLVYR

SPATA2

Spermatogenesis-associated protein 2

520 amino acids

Bridging factor that mediates the recruitment of CYLD to the LUBAC complex, thereby regulating TNF-alpha-induced necroptosis (PubMed:27307491, PubMed:27458237, PubMed:27545878, PubMed:27591049). Acts as a direct binding intermediate that bridges RNF31/HOIP, the catalytic subunit of the LUBAC complex, and the deubiquitinase (CYLD), thereby recruiting CYLD to the TNF-R1 signaling complex (TNF-RSC) (PubMed:27458237, PubMed:27545878, PubMed:27591049). Required to activate the 'Met-1'- (linear) and 'Lys-63'-linked deubiquitinase activities of CYLD (PubMed:27458237, PubMed:27591049). Controls the kinase activity of RIPK1 and TNF-alpha-induced necroptosis by promoting 'Met-1'-linked deubiquitination of RIPK1 by CYLD (By similarity).

Belongs to the SPATA2 family.

58.427 kDa

MGKPSSMDTKFKDDLFRKYVQFHESKVDTTTSRQRPGSDECLRVAASTLLSLHKVDPFYRFRLIQFYEVVESSLRSLSSSSLRALHGAFSMLETVGINLFLYPWKKEFRSIKTYTGPFVYYVKSTLLEEDIRAILSCMGYTPELGTAYKLRELVETLQVKMVSFELFLAKVECEQMLEIHSQVKDKGYSELDIVSERKSSAEDVRGCSDALRRRAEGREHLTASMSRVALQKSASERAAKDYYKPRVTKPSRSVDAYDSYWESRKPPLKASLSLRKEPVATDVGDDLKDEIIRPSPSLLTMASSPHGSPDVLPPASPSNGPALLRGTYFSTQDDVDLYTDSEPRATYRRQDALRPDVWLLRNDAHSLYHKRSPPAKESALSKCQSCGLSCSSSLCQRCDSLLTCPPASKPSAFPSKASTHDSLAHGASLREKYPGQTQGLDRLPHLHSKSKPSTTPTSRCGFCNRPGATNTCTQCSKVSCDACLSAYHYDPCYKKSELHKFMPNNQLNYKSTQLSHLVYR

Spata2

Spermatogenesis-associated protein 2

515 amino acids

Bridging factor that mediates the recruitment of CYLD to the LUBAC complex, thereby regulating TNF-alpha-induced necroptosis (By similarity). Acts as a direct binding intermediate that bridges RNF31/HOIP, the catalytic subunit of the LUBAC complex, and the deubiquitinase (CYLD), thereby recruiting CYLD to the TNF-R1 signaling complex (TNF-RSC) (By similarity). Required to activate the 'Met-1'- (linear) and 'Lys-63'-linked deubiquitinase activities of CYLD (PubMed:28701375). Controls the kinase activity of RIPK1 and TNF-alpha-induced necroptosis by promoting 'Met-1'-linked deubiquitination of RIPK1 by CYLD (PubMed:28701375).

Belongs to the SPATA2 family.

57.812 kDa

MDTKYKDDLFRKYVQFHEGKVDTTPGNQQPGSDEYLRVAAATLLSLHKVDPLYRFRLIQFYEVVESSLRSLSSSSLSALHCAFSMLETMAINLFLFPWKKEFRSIKTYTGPFVYYVKSTLLEKDIRAILRFMGYEPELGTVYKLKELVESLQVKMVSFELFLAKVECEQMLGIHSQVKDKGYSELDVVAERKGSTEDARGCSDALRRRAESREHLTTSMARVALQKSASERAAKDYYKPRVTKPSRSVDAYDSYWESRKPPSKASLSLRKEPLAMDVGEDLKDEIIRPSPSLLAMSSSPHGSPDDLSSISSINGLGLLRSTYFSTQDDVDLYTDSEPRATYRRQDALRPDVWLVKNDTHPIYHKRSPPTKESALSKCQNCGLSCSSSLCQRCDSVLVCPSASKPSAFPSKASVHDSLAHGAPMREKYVGHQTQGLDRLAPVHSKPKPSTTATSRCGFCNRAGATNTCTQCSKVSCDACLGAYHYDPCCRKSELHKFLPNSQLNYKSAPFSQLVYR

Spata2

Spermatogenesis-associated protein 2

511 amino acids

Bridging factor that mediates the recruitment of CYLD to the LUBAC complex, thereby regulating TNF-alpha-induced necroptosis. Acts as a direct binding intermediate that bridges RNF31/HOIP, the catalytic subunit of the LUBAC complex, and the deubiquitinase (CYLD), thereby recruiting CYLD to the TNF-R1 signaling complex (TNF-RSC). Required to activate the 'Met-1'- (linear) and 'Lys-63'-linked deubiquitinase activities of CYLD (By similarity). Controls the kinase activity of RIPK1 and TNF-alpha-induced necroptosis by promoting 'Met-1'-linked deubiquitination of RIPK1 by CYLD (By similarity).

Belongs to the SPATA2 family.

57.481 kDa

MDTKYKDDLFRKYVQFHEGKVDTTPGKQSGSDEYLRVAAATLLSLHKVDPLYRFRLIQFYEVVESSLRSLSSSSLSALHCAFSMLETMAINLFLFPWKKEFRSIKTYTGPFVYYVKSTLLEKDIRAILKFMGYEPELGTAYKLKELVESLQVKMVSFELFLAKVECEQMLGIHSQVKDKGYSELDVVTERKSSTEDARGCSDALRRRAESREHLTTSMARVALQKSASERAAKDYYKPRVTKPSRSVDAYDSYWESRKPPSKASLSLRKEPLAMDVGEDLKDEIIRPSPSLLTMSSSPHGSPDDLPSISPINGLGLLRSTYFPTQDDVDLYTDSEPRATYRRQDALRSDIWLVKNDAHSIYHKRSPPTKESALSKCQNCGLSCSSSLCQRCDSVCPSASKPSGFPSKASAHDSLVHGAPMREKYVGQTQGLDRLATVHSKPKPSTTATSRCGFCNRAGATNTCTQCSKVSCDPCLGAYHYDPCCRKSELHKFMPNNQLNYKSTQFSHPVYR