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spartin

Gene
spartin
Protein
Protein spartin
Organism
Drosophila melanogaster
Length
553 amino acids
Function
During postembryonic development, functions with endocytic adapter Eps-15 in neurons to restrain synaptic growth, by inhibiting BMP signaling, and to control synaptic endocytosis. Required presynaptically for neuromuscular junction (NMJ) neurotransmission. Inhibits neuronal BMP signaling by promoting endocytic internalization and subsequent endosomal trafficking of the BMP receptor wit. In this way, regulates the Fmr1 translational regulator controlling Futsch expression to modulate neuronal microtubule stability, which controls both synaptogenesis and neuronal survival.
Mass
59.784 kDa
Sequence
MAEEESEFLEAYAGIRTAYKAAMTQVDLAVSHEEQESPGQAIVAYELALRMIEDTFGIPVGLPNKIDTVQAEWNDACALIQKLKSAETELRYRLKVLRSQKQSIDDSAVEATEESRAEMDTKRPPLLAENPSTQYGIANASGAPKTYRELAAGLRELLAVRDAKVLLDELFRAQVKMYRIEASGSVTTISGSSTMSLVMCTVGGKWKYLSGIYFIQCSMPNEGTAGIWLYPLVPSITNCYQTEYGAFIFPDMECQQPGNAFGLMLTKEGQTSRTEDELEDLQQFFLDLLEAVLAGTVVQLKSPTSQRAGLASDTVSGSEQVSRHIVSAADFIASNLVRGAEKTGGFMLRSTPYIISKMTPASMDAQVPSSVQTSVEVAQKVTHAAAGMTGWIAGKVGTASMAVGRYLAPHIQEQGSKLLQKGFGYDTSEANSTMEGAMTIAAGAVEGVSTVFDGLETSAKILGSSLSENSVKIIEHKYGQQTGNLASGTFDTVGNVFVVSQNVNYITPKGIAKKMVKRTGEAVVSDYKRDLRKSESHYINAGSLYPDLRALKE