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soxR

Gene
soxR
Protein
HTH-type transcriptional regulator SoxR
Organism
Arthrobacter sp. (strain TE1826)
Length
289 amino acids
Function
Transcriptional repressor of soxA gene expression.
Similarity
Belongs to the LysR transcriptional regulatory family.
Mass
32.765 kDa
Sequence
MEIKDLQIFQKVVEYGSVSKAAKSLNYVQSYVTVRIQKLEEELQTELFHRSSRGMVLNSEGKTLLFYSQNIISMVDEMIKVVQDCDNPAGSLEIGTVETVNKLPSILSAYHKKYPKIDLSLITGVTEDLVDDVLNYKLDGAFVTGYYNHPQIIQYEVFEEELVLISNYDKLPFEELKNKPLLVFKQGCSYRAKLEGWVRDEGEINAKIMEFGTMETILGSVIAGLGITIIPKSTISLLEAEGVVRIYEIPEKYSKITTVFIHRADTFLTNALQKFIETIKNAPETARKL

Gene
soxR
Protein
Redox-sensitive transcriptional activator SoxR
Organism
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Length
156 amino acids
Function
Activates the transcription of the soxS gene which itself controls the superoxide response regulon. SoxR contains a 2Fe-2S iron-sulfur cluster that may act as a redox sensor system that recognizes superoxide. The variable redox state of the Fe-S cluster is employed in vivo to modulate the transcriptional activity of SoxR in response to specific types of oxidative stress (By similarity).
Mass
16.998 kDa
Sequence
MKNSCASRELSVGELARRAGVAVSALHFYETKGLISSQRNAGNQRRFSRETLRRVVVIKVAQRVGIPLAEIARALQTLPAGRSPSAADWARLSAQWKEDLTERIDKLLLLRDQLDGCIGCGCLSLQACPLRNPGDQLSAEGPGAHWLDAEGREHDG

Gene
soxR
Protein
Redox-sensitive transcriptional activator SoxR
Organism
Escherichia coli O157:H7
Length
154 amino acids
Function
Activates the transcription of the soxS gene which itself controls the superoxide response regulon. SoxR contains a 2Fe-2S iron-sulfur cluster that may act as a redox sensor system that recognizes superoxide. The variable redox state of the Fe-S cluster is employed in vivo to modulate the transcriptional activity of SoxR in response to specific types of oxidative stress. Upon reduction of 2Fe-2S cluster, SoxR reversibly loses its transcriptional activity, but retains its DNA binding affinity (By similarity).
Mass
17.15 kDa
Sequence
MEKKLPRIKALLTPGEVAKRSGVAVSALHFYESKGLITSIRNSGNQRRYKRDVLRYVAIIKIAQRIGIPLATIGEAFGVLPEGHTLSAKEWKQLSSQWREELDRRIHTLVALRDELDGCIGCGCLSRSDCPLRNPGDRLGEEGTGARLLEDEQN

Gene
soxR
Protein
Redox-sensitive transcriptional activator SoxR
Organism
Escherichia coli (strain K12)
Length
154 amino acids
Function
Activates the transcription of the soxS gene which itself controls the superoxide response regulon. SoxR contains a 2Fe-2S iron-sulfur cluster that may act as a redox sensor system that recognizes superoxide. The variable redox state of the Fe-S cluster is employed in vivo to modulate the transcriptional activity of SoxR in response to specific types of oxidative stress. Upon reduction of 2Fe-2S cluster, SoxR reversibly loses its transcriptional activity, but retains its DNA binding affinity.
Mass
17.15 kDa
Sequence
MEKKLPRIKALLTPGEVAKRSGVAVSALHFYESKGLITSIRNSGNQRRYKRDVLRYVAIIKIAQRIGIPLATIGEAFGVLPEGHTLSAKEWKQLSSQWREELDRRIHTLVALRDELDGCIGCGCLSRSDCPLRNPGDRLGEEGTGARLLEDEQN

Gene
soxR
Protein
Redox-sensitive transcriptional activator SoxR
Organism
Shigella flexneri
Length
154 amino acids
Function
Activates the transcription of the soxS gene which itself controls the superoxide response regulon. SoxR contains a 2Fe-2S iron-sulfur cluster that may act as a redox sensor system that recognizes superoxide. The variable redox state of the Fe-S cluster is employed in vivo to modulate the transcriptional activity of SoxR in response to specific types of oxidative stress. Upon reduction of 2Fe-2S cluster, SoxR reversibly loses its transcriptional activity, but retains its DNA binding affinity (By similarity).
Mass
17.15 kDa
Sequence
MEKKLPRIKALLTPGEVAKRSGVAVSALHFYESKGLITSIRNSGNQRRYKRDVLRYVAIIKIAQRIGIPLATIGEAFGVLPEGHTLSAKEWKQLSSQWREELDRRIHTLVALRDELDGCIGCGCLSRSDCPLRNPGDRLGEEGTGARLLEDEQN

Gene
soxR
Protein
Redox-sensitive transcriptional activator SoxR
Organism
Salmonella typhi
Length
152 amino acids
Function
Activates the transcription of the soxS gene which itself controls the superoxide response regulon. SoxR contains a 2Fe-2S iron-sulfur cluster that may act as a redox sensor system that recognizes superoxide. The variable redox state of the Fe-S cluster is employed in vivo to modulate the transcriptional activity of SoxR in response to specific types of oxidative stress (By similarity).
Mass
16.875 kDa
Sequence
MEKKSPRLKALLTPGEVAKRSGVAVSALHFYESKGLITSIRNSGNQRRYKRDVLRYVAIIKIAQRIGIPLATIGDAFGILPEGHTLSAKEWKQLSSQWREELDRRIHTLVALRDELDGCIGCGCLSRSDCPLRNPGDRLGEHGTGARLLEDD

Gene
soxR
Protein
Redox-sensitive transcriptional activator SoxR
Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Length
152 amino acids
Function
Activates the transcription of the soxS gene which itself controls the superoxide response regulon. SoxR contains a 2Fe-2S iron-sulfur cluster that may act as a redox sensor system that recognizes superoxide. The variable redox state of the Fe-S cluster is employed in vivo to modulate the transcriptional activity of SoxR in response to specific types of oxidative stress (By similarity).
Mass
16.875 kDa
Sequence
MEKKSPRLKALLTPGEVAKRSGVAVSALHFYESKGLITSIRNSGNQRRYKRDVLRYVAIIKIAQRIGIPLATIGDAFGILPEGHTLSAKEWKQLSSQWREELDRRIHTLVALRDELDGCIGCGCLSRSDCPLRNPGDRLGEHGTGARLLEDD

Gene
soxR
Protein
HTH-type transcriptional activator SoxR homolog
Organism
Chromobacterium violaceum (strain ATCC 12472 / DSM 30191 / JCM 1249 / NBRC 12614 / NCIMB 9131 / NCTC 9757)
Length
148 amino acids
Mass
16.427 kDa
Sequence
MEESTITIGRLAKRTGVAASALRFYEARGLIHSVGEAGKTRRYRRDAIRRVSFIRVAQAMGMSLQDIGAALADLPSQRTPTADDWARISQAWKPLLQERIDALCRLRDQLDSCIGCGCLSLERCKLYNPDDKAGEQGCGPRFLLDEKA