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sox9-b

Gene
sox9-b
Protein
Transcription factor Sox-9-B
Organism
Xenopus laevis
Length
476 amino acids
Function
Transcription activator. Acts early in neural crest formation, functioning redundantly with the other group E Sox factors sox8 and sox10 to induce neural crest progenitors. Induces sox10 expression downstream of wnt-signaling. Principally involved in development of the cranial neural crest, which is fated to form skeletal elements. Also required for otic placode specification during inner ear development. May be involved in chondrogenesis (cartilage development) during bone formation. Unlikely to play a role in sex determination but may function during testicular and ovarian differentiation (By similarity).
Mass
53.32 kDa
Sequence
MNLLDPFMKMSEEQDKCLSGAPSPTMSEDSAGSPCPSGSGSDTENTRPQENTFPKGDQEMKKETEDEKFPVCIREAVSQVLKGYDWTLVPMPVRVNGSSKNKPHVKRPMNAFMVWAQAARRKLADQYPHLHNAELSKTLGKLWRLLNEGEKRPFVEEAERLRVQHKKDHPDYKYQPRRRKSVKNGQSEQDDSAEQTHISPNAIFKALQADSPHSTSSMSEVHSPGEHSGQSQGPPTPPTTPKTDVQPGKPDLKREGRPLQESGRQPPHIDFRDVDIGELSSEVISTIETFDVNEFDQYLPPNGHPGVGSAQAPYTGSYGISSTPSATTGAGSAWMSKQQQQPQQHSLSTINSEQSQSQQRTHIKTEQLSPSHYSDQQQQHSPQQLNYSSFNLQHYSSSYPTITRAQYDYTEHQGSNSYYTHASGQNSGLYSNFTYMNPSQRPMYTPIADTTGVPSIPQTHSPQHWEQPVYTQLTRP