About Products Protein Database Contact

sox-2

Gene
sox-2
Protein
Transcription factor sox-2
Organism
Caenorhabditis elegans
Length
283 amino acids
Function
Probable transcription factor that regulates the lineage progression of embryonic blast cells and controls the postmitotic specification and differentiation of neurons (PubMed:26153233, PubMed:26341465). Cooperates with additional factors to direct the differentiation of the olfactory neurons, functioning with the transcription factor ceh-36 to specify AWC neurons and with the LIM homeodomain factor lim-4 to suppress AWC terminal differentiation and promote AWB neuron differentiation (PubMed:26341465). Plays a role in the terminal differentiation of glutamatergic and cholinergic neurons (PubMed:26153233). Required for natural reprogramming events and in particular for the transdifferentiation of the Y rectal epithelial cell to the PDA motor neuron during larval development (PubMed:22493276).
Mass
32.169 kDa
Sequence
MMMDPDSAKMQDYSGWSFGFHMPPTSSTNLLPQSMPDDLSNGPDSPDSTGKDGKKNDDRVKRPMNAFMVWSRGQRKKMALENPKMHNSEISKRLGTEWKMLSEQEKRPFIDEAKRLRAIHMKEHPDYKYRPRRKTKSINKKNGAPIPFGNLDTKTPSYPTLTTNWNATNQYIDQFRFAPYPTTTVMDQIPFSLTYPVHSVPTDNSSPSQFQPSPMSTNFAGSYLTPKSESSPVGSDSTVGTVDSSQFRAYYDHTKDQMMYPYSIELTHAQNIQNALSQSHVTS