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sorf-1

Gene
sorf-1
Protein
Suppressor of organelle fusion 1
Organism
Caenorhabditis elegans
Length
239 amino acids
Function
Together with sorf-2 negatively regulates the levels of phosphatidylinositol 3-phosphate (PtdIns3P) to enable the conversion of early endosomes to late endosomes. Binds to sorf-2 and the sorf-1-sorf-2 complex likely acts through bec-1, a non-catalytic subunit of phosphatidylinositol 3-kinase (PI3K), to suppress PI3K activity, thereby negatively regulating endosomal PtdIns3P levels.
Similarity
Belongs to the WD repeat WDR91 family.
Mass
27.242 kDa
Sequence
MSHVSNSTDEVVRNYLAAKSMVTSLKAFDQESSFAKEANYQVDRCIDEMTDAIDKHDVDTLCAMWESWNARVFHSLDTEGIKQAQCYEASAYRLFLVRCVQKKNISKCNEFFRKMSSLTLNNPQWADWFAFPYNHHAKDTEPFRKYFDKTWIEIYYVSLHNFLSTSLANVSPSVIGTIVEGIARDPTGNDHVDFDEDLIDDFAVIAQCSAPVKRGHSKPSLRNLLKSLTSSKKPSPSTD