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sorC

Gene
sorC
Protein
FAD-dependent monooxygenase sorC
Organism
Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255)
Length
445 amino acids
Function
FAD-dependent monooxygenase; part of the gene cluster that mediates the biosynthesis of sorbicillinoids, a diverse group of yellow secondary metabolites that restrict growth of competing pathogenic fungi but not of bacteria (PubMed:25580210, PubMed:28618182). Sorbicillinoids biosynthesis requires the action of two PKSs (PubMed:25580210). SorA iteratively combines three acetyl units and the growing chain is modified by the ketoacyl reductase subunit, and optional by the enoyl reductase subunit in the second cycle (PubMed:25580210). The polyketide is then handed over to the PKS SorB, which adds three more acetyl units, and two methyl groups (PubMed:25580210). SorB releases an aldehyde, which undergoes spontaneous cyclization resulting in the formation of sorbicillin or 2',3'-dihydrosorbicillin (PubMed:25580210). The monooxygenase sorC oxidizes sorbicillin and 2',3'-dihydrosorbicillin to 2',3'-dihydrosorbicillinol and sorbicillinol, respectively (PubMed:28618182). The oxidoreductase sorD further converts sorbicillinol into oxosorbicillinol (PubMed:28618182). Sorbicillinol is the building block for the other sorbicillinoids such as disorbicillinol, bisvertinolon, and dihydrobisvertinolone (By similarity).
Similarity
Belongs to the paxM FAD-dependent monooxygenase family.
Mass
48.16 kDa
Sequence
MTRSANSPFEVAIVGGGITGLALAVGLLKRNVSFTIYERAENFGELGVGITFTPNAQRAMEALDPCVLQSFTNVASAPSGGTINFVDGVREQGSEDPRTSTAALLFQLHVKGGYKACRRCDFVDQIVQHIPKDCVQYRKWLDSIETDHESGRAVLKFRDGEIAHADVVIGCDGIRSQVRASMFGTDELCPRAQYSHQLGYRGMVPLAQATAVLGPEKTSSAVLHTGPGAFVLTIPLAEVHAMHIEAFIMDKEEWPEVQTSSDSKRYVLPATRNEATKAFAEFGPTVRSAVSMFPEKLEKWAVFDMLEAPVPTFAKGRVCLAGDAAHASTPNQGGGAGFGIEDALVLAEVLAVLAEAPNVSGIVASEALAVYSEVRYERSQWLVRSSRRTGELCTWKDRDWGLAAEELSRDIISRSHQLWDHDTAGMVSDALAILGERVRGADTAF

Gene
sorC
Protein
Sorbitol operon regulator
Organism
Klebsiella pneumoniae
Length
315 amino acids
Function
Positively regulates, in the presence of L-sorbose, and negatively regulates, in the absence of L-sorbose, the transcription of the sor operon.
Similarity
Belongs to the SorC transcriptional regulatory family.
Mass
35.104 kDa
Sequence
MENSDDIRLIVKIAQLYYEQDMTQAQIARELGIYRTTISRLLKRGREQGIVTIAINYDYNENLWLEQQLKQKFGLKEAVVASSDGLLEEEQLSAMGQHGALLVDRLLEPGDIIGFSWGRAVRSLVENLPQRSQSRQVICVPIIGGPSGKLESRYHVNTLTYGAAARLKAESHLADFPALLDNPLIRNGIMQSQHFKTISSYWDSLDVALVGIGSPAIRDGANWHAFYGSEESDDLNARHVAGDICSRFYDINGGLVDTNMSEKTLSIEMAKLRQARYSIGIAMGEEKYSGILGALHGRYINCLVTNRETAELLLK

Gene
sorC
Protein
PTS system sorbose-specific EIIC component
Organism
Lactobacillus casei
Length
277 amino acids
Function
The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. The enzyme II SorABCD PTS system is involved in L-sorbose transport.
Mass
29.002 kDa
Sequence
MAISTIQIILIFIWSSVVGMGSVLDEFQTHRPLIACSIMGLILGDPKTGIILGGTLELIALGWMNIGAAQSPDSALASTISTILVIVGNQDIQKGIAIALPVAAAGQVLTVLARTVTVAFQHAADREAEKANFTAIIWLHFTALIVQALRVSIPTTIVAVFVSPEEIKSMLDALPEVITGGLAVAGGFIVVVGYAMILNMMSVKYLMPFFYQGFVLGGYLKLSLLAWGAVGLIFAIVYVQLNPKFATNHNNGTGGSGGTVAAAGDHPAALPEDELDD