soc-2

Gene

soc-2

Protein

Leucine-rich repeat protein soc-2

Organism

Caenorhabditis briggsae

Length

559 amino acids

Function

Acts as a Ras effector and participates in MAPK pathway activation. Probably acts as a regulatory subunit of protein phosphatase that specifically dephosphorylates Raf kinase and stimulates Raf activity at specialized signaling complexes upon Ras activation. Required for vulval development. Involved in fluid homeostasis. Plays a role in nicotinic acetylcholine receptor (nAChR)-mediated sensitivity to nicotine.

Similarity

Belongs to the SHOC2 family.

Mass

62.523 kDa

Sequence

METSKEFEFRPAKETSRSKSPGGIVGRLSNFARNKARHSLSEKGSNSVGGSGGSGFDKPRKDLLKEFHKCKEAQDQRLDLSSIEITSIPSPIKELTQLTELFLYKNKLTCLPTEIGQLVNLKKLGLSENALSSLPDSLSSLESLETLDLRHNKLTEVPAVIYKITSLETLWLRYNRIVAVDEQIGNLQKLKMLDVRENKIRELPSAIGKLSSLVVCLVSYNHLTRVPEEIGECHALTQLDLQHNDLSELPYSIGKLTNLVRIGIRYNKIRCIPSELESCQQLEEFIVESNHLQLLPPNLLTMLPKIHTVNLSRNELTAFPAGGPQQFVPTVTINMEHNQISKIPIGIFSKATRLTKLNLKENELVSLPLDMGSWTSITELNLSTNQLKVLPEDIEKLVNLEILVLSNNQLKKLPNQIGNLKKLRELDLEENELETVPTEIGFLQHLTKLWVQSNKIVTLPRSIGNLCSLQDLRLGENNLTAIPEEIGHLDSLKSLYLNDNSSLHNLPFELALCQSLEIMSIENSPLSQIPPEITAGGPSLVIQYLKMQGPYRGVVMTGQ

Protein

Leucine-rich repeat protein soc-2: soc-2

Gene

soc-2

Protein

Leucine-rich repeat protein soc-2

Organism

Caenorhabditis elegans

Length

559 amino acids

Function

Acts as a Ras effector and participates in MAPK pathway activation (PubMed:9674433, PubMed:9618511). Probably acts as a regulatory subunit of protein phosphatase that specifically dephosphorylates Raf kinase and stimulates Raf activity at specialized signaling complexes upon Ras activation (PubMed:10521400, PubMed:14685271). Required for vulval development (PubMed:10521400). Involved in fluid homeostasis (PubMed:11689700). Plays a role in nicotinic acetylcholine receptor (nAChR)-mediated sensitivity to nicotine (PubMed:15990870).

Similarity

Belongs to the SHOC2 family.

Mass

62.483 kDa

Sequence

METSKEFEFRPAKETSRSKSPGGIVGRLSNFARNKARHSLSEKGSNSVGGSGGAGFDKPRKDLLKEFHKCKEAQDQRLDLSSIEITSIPSPIKELTQLTELFLYKNKLTCLPTEIGQLVNLKKLGLSENALTSLPDSLASLESLETLDLRHNKLTEVPSVIYKIGSLETLWLRYNRIVAVDEQIGNLSKLKMLDVRENKIRELPSAIGKLTSLVVCLVSYNHLTRVPEEIGDCHSLTQLDLQHNDLSELPYSIGKLVNLVRIGIRYNKIRCIPSELESCQQLEEFIVESNHLQLLPPNLLTMLPKIHTVNLSRNELTAFPAGGPQQFVSTVTINMEHNQISKIPIGIFSKATRLTKLNLKENELVSLPLDMGSWTSITELNLSTNQLKVLPEDIEKLVNLEILVLSNNQLKKLPNQIGNLNKLRELDLEENELETVPTEIGFLQHLTKLWVQSNKILTLPRSIGNLCSLQDLRLGENNLTAIPEEIGHLDSLKSLYLNDNSSLHNLPFELALCQSLEIMSIENSPLSQIPPEITAGGPSLVIQYLKMQGPYRGVVMNSQ

Protein

Leucine-rich repeat protein soc-2: soc-2