Function
Adapter protein which modulates signaling mediated by several receptor tyrosine kinases. Plays a role in fluid homeostasis, probably downstream of receptor egl-15 and upstream of let-60/Ras (PubMed:11689700). Involved in nicotinic acetylcholine receptor (nAChR)-mediated sensitivity to nicotine and levamisole and gamma-aminobutyric acid (GABA)receptor-mediated sensitivity to muscimol (PubMed:15990870). Regulates synaptic levels of nAchR receptor subunit lev-1 and unc-38, and GABA receptor subunit unc-49 in the nerve cord, probably downstream of egl-15 (PubMed:15990870). Regulates motility (PubMed:15990870). During the formation of neuromuscular junctions at the larval stage, down-regulates membrane protrusion from body wall muscles, probably downstream of egl-15 (PubMed:16495308). Promotes vulva induction and down-regulates fertility, probably downstream of receptor let-23 (PubMed:16547100). Down-regulates daf-2-mediated repression of dauer formation and positively regulates daf-2-mediated aging (PubMed:16547100). May be involved in the recruitment of phosphatase ptp-2 to egl-15 (PubMed:11689700).
Sequence
MSIPDENIILEGSLKRCKKYKLFKTKWVEHYFVLHCRDRERNLFAIDEFKTSRKNDLKKRFKLEFVIRVESNLSVSDPSILCTAGGGHQEESMLNCIFGVGFRFENIVKDLYLVAKNDEEMTLWVNEICKLCKLHRQHDEGDSSHAAESSISGMSMSSQSLDMSIIEQQQYAENIPESKQYHRMHHFKSVISHNSLPSNPNYNNLPDPLESSRSETSSMYSSRRTEDDSVSYTSGPPVPPPRTRHTLNRFVKNGQVGRLHMIPASTSMGQVVKVEDAEDSSGETLKLDTPEQYPESVTSSEGFPVYERNGKTLIRRAPPPVDRSNKPKNLRGEEEAGTRYRNLSRNGVNENGNYSATFSSRTSNYQQSETSKRRNLDYFEPTQMIENSSLSTLAATSTRSPTPSDIEYISVDVDRTLAFKQMRRAAQSTD