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snf8

Gene
snf8
Protein
Vacuolar-sorting protein SNF8
Organism
Danio rerio
Length
258 amino acids
Function
Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex (By similarity).
Similarity
Belongs to the SNF8 family.
Mass
28.85 kDa
Sequence
MHRRGVGAGAIAKKKLAEAKYKERGSVLAEDQIAQMSKQLDTFKTHLEEFASKHKQEIRKSSQFRVQFQEMCATIGVDPLASGKGFWSEMLGVGDFYYELGVQIIEVCLALKHRNGGLITLDELHHRVLKGRGKFAQDVSQDDLVRAIKKLKAMGNGFGMIPVGGTYLVQSVPAELNMDHTVVLQLAEKKGYVTVSEIRESLKWEKERACHVLDHLLKEGLAWLDSQAAGEPQYWLPALFSELLSQDVTPEEANQMTP

Gene
SNF8
Protein
Vacuolar-sorting protein SNF8
Organism
Homo sapiens
Length
258 amino acids
Function
Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a role in transcription regulation by participating in derepression of transcription by RNA polymerase II, possibly via its interaction with ELL. Required for degradation of both endocytosed EGF and EGFR, but not for the EGFR ligand-mediated internalization. It is also required for the degradation of CXCR4. Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413).
Similarity
Belongs to the SNF8 family.
Mass
28.864 kDa
Sequence
MHRRGVGAGAIAKKKLAEAKYKERGTVLAEDQLAQMSKQLDMFKTNLEEFASKHKQEIRKNPEFRVQFQDMCATIGVDPLASGKGFWSEMLGVGDFYYELGVQIIEVCLALKHRNGGLITLEELHQQVLKGRGKFAQDVSQDDLIRAIKKLKALGTGFGIIPVGGTYLIQSVPAELNMDHTVVLQLAEKNGYVTVSEIKASLKWETERARQVLEHLLKEGLAWLDLQAPGEAHYWLPALFTDLYSQEITAEEAREALP

Gene
Snf8
Protein
Vacuolar-sorting protein SNF8
Organism
Mus musculus
Length
258 amino acids
Function
Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a role in transcription regulation by participating in derepression of transcription by RNA polymerase II, possibly via its interaction with ELL. Required for degradation of both endocytosed EGF and EGFR, but not for the EGFR ligand-mediated internalization. Required for the exosomal release of SDCBP, CD63 and syndecan (By similarity).
Similarity
Belongs to the SNF8 family.
Mass
28.886 kDa
Sequence
MHRRGVGAGAIAKKKLAEAKYKERGTVLAEDQLAQMSKQLDMFKTNLEEFASKHKQEIRKNPEFRVQFQDMCATIGVDPLASGKGFWSEMLGVGDFYYELGVQIIEVCLALKHRNGGLITLEELHQQVLKGRGKFAQDVSQDDLIRAIKKLKALGTGFGIIPVGGTYLIQSVPAELNMDHTVVLQLAEKNGYVTVSEIKTSLKWETERARQVLEHLLKEGLAWLDLQAPGEAHYWLPALFTDLYSQEISAEEAKEAFP

Gene
Snf8
Protein
Vacuolar-sorting protein SNF8
Organism
Rattus norvegicus
Length
258 amino acids
Function
Required for degradation of both endocytosed EGF and EGFR, but not for the EGFR ligand-mediated internalization (By similarity). Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a role in transcription regulation by participating in derepression of transcription by RNA polymerase II, possibly via its interaction with ELL.Required for the exosomal release of SDCBP, CD63 and syndecan (By similarity).
Similarity
Belongs to the SNF8 family.
Mass
28.884 kDa
Sequence
MHRRGVGAGAIAKKKLAEAKYKERGTVLAEDQLAQMSKQLDMFKTNLEEFASKHKQEIRKNPEFRVQFQDMCATIGVDPLASGKGFWSEMLGVGDFYYELGVQIIEVCLALKHRNGGLITLEELHQQVLKGRGKFAQDVSQDDLIRAIKKLKALGTGFGIIPVGGTYLIQSVPAELNMDHTVVLQLAEKNGYVTVSEIKASLKWETERARQVLEHLLKEGLAWLDLQAPGEAHYWLPALFTDLYSQEISAEEAKEVFP

Gene
snf8
Protein
Vacuolar-sorting protein SNF8
Organism
Xenopus tropicalis
Length
257 amino acids
Function
Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex (By similarity).
Similarity
Belongs to the SNF8 family.
Mass
28.607 kDa
Sequence
MHRRGVGAGAIAKKKLAEAKYKERGTVLAEDQLLQMSKQLEMFKTNLEEFASKHKQEIRKNPQFRVQFQDMCATIGVDPLASGKGFWSEMLGVGDFYYELGVQIIEVCLALKHHNGGLITLAELHQHVLKGRGKLAQDVSQDDIIRAIKKLKVLGNGFGIIPVGGSYLVQSVPAELNMDHTVVLQLAEKKGFVTVNEIKSSLNWETERAKHVLEHLLKEGLAWIDSQAQGEAQYWLPALFTALYAQQINMDENGGPS

Gene
snf8
Protein
Vacuolar-sorting protein SNF8
Organism
Dictyostelium discoideum
Length
246 amino acids
Function
Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation (By similarity).
Similarity
Belongs to the SNF8 family.
Mass
28.277 kDa
Sequence
MRRGIGIQAAQKQTQTQKQLQNVSEQLNTENINKIKEQLLVFKENLEIFATKHKKDIIKNPEFRKYFQDMCNMIGVDPLASNKGFWCQVLGVGDFYYTLGVQIIEICLKYRSSNGGLMEMDTLAEHLRKLRGKNSQEISCDDIECSISKLKVLGNGFNIIKVSGGKKLVQSVPCELNKDHTDIIILAQDNNASITQSLVISKLKWSEERINNVINFLLQESMIWIDEQSNETIYWFPSLWSNFSFE

Gene
SNF8
Protein
Vacuolar-sorting protein SNF8
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Length
233 amino acids
Function
Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex.
Similarity
Belongs to the SNF8 family.
Mass
26.954 kDa
Sequence
MKQFGLAAFDELKDGKYNDVNKTILEKQSVELRDQLMVFQERLVEFAKKHNSELQASPEFRSKFMHMCSSIGIDPLSLFDRDKHLFTVNDFYYEVCLKVIEICRQTKDMNGGVISFQELEKVHFRKLNVGLDDLEKSIDMLKSLECFEIFQIRGKKFLRSVPNELTSDQTKILEICSILGYSSISLLKANLGWEAVRSKSALDEMVANGLLWIDYQGGAEALYWDPSWITRQL