Protein
N-lysine methyltransferase SMYD2-A
Function
Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. Specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). Shows even higher methyltransferase activity on p53/TP53. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates RB1 at 'Lys-860' (By similarity).
Similarity
Belongs to the class V-like SAM-binding methyltransferase superfamily.
Sequence
MGQPEGLERFDSPGKGRGLKATRSFALGELLFTCPAYTYVLTDTERGNHCDFCFARKEGLSKCGKCKQAFYCNVDCQKGDWPMHKLECSAMCSYGQNWCPSETVRLTARILAKQKTQTERTPSETFLSVKEFESHLSKLDNEKKELIESDIAALHRFYSKNLHYTDNAALVFLFAQVNCNGFTIEDEELSHLGSAIFPDVALMNHSCCPNIIVTFKGTVAEIRAVQEIHAGDEVFTSYIDLLYPTEDRNDRLMDSYFFTCDCRECSTKQKDPAKLEIRKLSDPPSHQTVKDMIKYARNIVEEFRRAKHYKTPSELLEMCELSLDKMGSVFVDSNVYMLHMMYQAMGVCLYLQEWDGALKYGEKIIKPYSKHYPAYSLNVASMWLKLGRLYMGLEKTTIGTKALKKALAIMQIAHGPDHHYIAEIKKELEL