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sms-3

Gene
sms-3
Protein
Putative phosphatidylcholine:ceramide cholinephosphotransferase 3
Organism
Caenorhabditis elegans
Length
340 amino acids
Function
Bidirectional lipid cholinephosphotransferase capable of converting phosphatidylcholine (PC) and ceramide to sphingomyelin (SM) and diacylglycerol (DAG) and vice versa. Direction is dependent on the relative concentrations of DAG and ceramide as phosphocholine acceptors. Directly and specifically recognizes the choline head group on the substrate. Also requires two fatty chains on the choline-P donor molecule in order to be recognized efficiently as a substrate. Does not function strictly as a SM synthase (By similarity).
Similarity
Belongs to the sphingomyelin synthase family.
Mass
38.185 kDa
Sequence
MGSVSKTVISARGASPDDEQNGTKNGISNGSEWAKCIFLFFFLFIAGMSNWAVLAYTHDYVPRESLPDIVFSLVSEQRWASSLGDFCVALCIVMLGALLVIHQHRGTILKRVVFCAGTLYAMRSVTLAATQLPSGYTDNQGRCRDQVESEAGVFFGRLFEQTIRIGFQSKDQMLCGDLLFSGHTLVMVTCSLAVAYYLPKSIKPLQWVSHVACLIGMICMTISRTHYTIDVVIAYWLSNMVFRMYHAYCEVDMCMERRKSILYSWWPCRIVDWLEQDIVPGRLENRCQLPWRRSTPRGQERGGASAESSDSSVTMCDNITTSHHQKHVSISSSSTYPLPC