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smpd4

Gene
SMPD4
Protein
Sphingomyelin phosphodiesterase 4
Organism
Homo sapiens
Length
866 amino acids
Function
Catalyzes the hydrolysis of membrane sphingomyelin to form phosphorylcholine and ceramide (PubMed:16517606). May sensitize cells to DNA damage-induced apoptosis (PubMed:18505924).
Mass
97.81 kDa
Sequence
MTTFGAVAEWRLPSLRRATLWIPQWFAKKAIFNSPLEAAMAFPHLQQPSFLLASLKADSINKPFAQQCQDLVKVIEDFPAKELHTIFPWLVESIFGSLDGVLVGWNLRCLQGRVNPVEYSIVMEFLDPGGPMMKLVYKLQAEDYKFDFPVSYLPGPVKASIQECILPDSPLYHNKVQFTPTGGLGLNLALNPFEYYIFFFALSLITQKPLPVSLHVRTSDCAYFILVDRYLSWFLPTEGSVPPPLSSSPGGTSPSPPPRTPAIPFASYGLHHTSLLKRHISHQTSVNADPASHEIWRSETLLQVFVEMWLHHYSLEMYQKMQSPHAKLEVLHYRLSVSSALYSPAQPSLQALHAYQESFTPTEEHVLVVRLLLKHLHAFANSLKPEQASPSAHSHATSPLEEFKRAAVPRFVQQKLYLFLQHCFGHWPLDASFRAVLEMWLSYLQPWRYAPDKQAPGSDSQPRCVSEKWAPFVQENLLMYTKLFVGFLNRALRTDLVSPKHALMVFRVAKVFAQPNLAEMIQKGEQLFLEPELVIPHRQHRLFTAPTFTGSFLSPWPPAVTDASFKVKSHVYSLEGQDCKYTPMFGPEARTLVLRLAQLITQAKHTAKSISDQCAESPAGHSFLSWLGFSSMDTNGSYTANDLDEMGQDSVRKTDEYLEKALEYLRQIFRLSEAQLRQFTLALGTTQDENGKKQLPDCIVGEDGLILTPLGRYQIINGLRRFEIEYQGDPELQPIRSYEIASLVRTLFRLSSAINHRFAGQMAALCSRDDFLGSFCRYHLTEPGLASRHLLSPVGRRQVAGHTRGPRLSLRFLGSYRTLVSLLLAFFVASLFCVGPLPCTLLLTLGYVLYASAMTLLTERGKLHQP

Gene
smpd4
Protein
Sphingomyelin phosphodiesterase 4
Organism
Xenopus laevis
Length
824 amino acids
Function
Catalyzes the hydrolysis of membrane sphingomyelin to form phosphorylcholine and ceramide.
Mass
93.796 kDa
Sequence
MLLAGGSPQPSFLLGSLKADCVTKPFLQRCQDLVRVIEDFPAKELHAIFPWLIETVFGSLDGSILGWNLRGLHERINPLEFHTALEFLDPSGAMMKLVYKLQAEEYKYDFPVSFLPGPVRASIQERVLPECPLYHNKIQFPASGGVSFNLALNSFEYFMFHFAFCLLKQRNYPQGLHFSTADSAYYILVDKYLKWFLPVEGNVPPPHSPNTGGTVPSPAPRSPSLSFTSYGSHTSLLKRHISHQHLVNADPAAQEIWRTETLLQVFVEIWLHHYSLEMYQKMQSPNAKLEALHNRLSVSSAPPIYPALPGSLHSYQELFQPTEEHVLVVRLLVKHLHTFSNSIRPEQVSPSTHSHTASPLEELKRVVVPRFIQQKLYIFLQHCFGHWPLDASFRAVLEMWLSYVQPWRYVLERSSPVSGEMQNRNVPEKWSTFVQENLLFYTKLFLRFLSRALRTDLVNPKNALMVFRAAKVFSQLNLPEMILNGEQLFLKPEHVIPHRQHRLLLTPNLGGSFLSSWQPPITDTSLKVKSHVFSLEGQDCQYMQMFGPEARNLVLRLAQMISQAKQTAKSISNHSPDSSANQSFLSWFGLGSPDFNGSYNGSDLDEAGYDTIRKTDEHLEKALDYFCQIFRLNPTQLGQLTANVDSSQDDDGKNKLPDCIQSEDGVVLTSLGRYQIINGLRKFDIEYQGDPELQPIRSYENAMLVRYLYRLSSVINKRFANSMGALCARKDFLGKLCRHHLTSSSRKCKKSPITSVSPSEPAAPHIRLRFLASYRTLAFLFIFYILGSLLSLGPLICTFLLLIGCMFYAIVQTLLSEEQKPHNN

Gene
Smpd4
Protein
Sphingomyelin phosphodiesterase 4
Organism
Mus musculus
Length
823 amino acids
Function
Catalyzes the hydrolysis of membrane sphingomyelin to form phosphorylcholine and ceramide. May sensitize cells to DNA damage-induced apoptosis.
Mass
93.276 kDa
Sequence
MAFPHLQQPSFLLASLKADSINKPFAQRCQDLVKVIEDFPAKELHAVFPWLVESIFGSLDGVLVGWNLRCLQGRVNPVEYSTAMEFLDPSGPMMKLVYKLQAEDYNFDFPVSCLPGPVKASIQENVLPDSPLYHNKVQFPPTGGLGLNLALNPFEYYMFYFALSLISQKPMSMTLHVRTSDCAYFTLVDRYLSWFLPTEGSVPPPLCSSPGGSSPSPAPRTPAMPFASYGLHTSLLKRHISHQTSVNADPASHEIWRSETLLQVFVEMWLHHYSLEMYQKMQSPHAKLEVLHYRLTVSSALHSPAQPSLQALHAYQESFTPTEEHVLVVRLLLKHLHAFANSLKPDQASPSAHSHATSPLEEFKRAAVPRFVQQKLYVFLQHCFGHWPLDATFRAVLEMWLSYLQPWRYAPEKQAQGSDPQPRCVSEKWAPFIQENLLMYTKLFVSFLNRALRTDLVSPKNALMVFRVAKVFAQPNLAEMIQKGEQLFLEPELIIPHRQHRLFTVTTSFLSPWPPVVTDASFKVKSHVYSLEGQDCKYTPMFGPEIRTLVLRLAQLITQAKQTAKSISDQYVESPTGRSFLSWLTFGLTDTNSCYPANDLDEIGQDSIRKTDEYLEKALEYLRQIFRLSEAQLAQLTLALGSARDENGKQQLPDCIVGEEGLILTPLGRYQIINGLRRFEIEYQGDLELQPIRSYEITSLVRALFRLSSAINRRFAGQMAALCSRNDFLGSFCRYHLTEPALSNRHLLSPVGRRQVTNPARGPRLSLRFLGSYRTLLLLLMAFFVASLFCIGPLSCSLLLVLGYVLYAIAMTLLTERGKLHQL

Gene
smpd4
Protein
Sphingomyelin phosphodiesterase 4
Organism
Danio rerio
Length
791 amino acids
Function
Catalyzes the hydrolysis of membrane sphingomyelin to form phosphorylcholine and ceramide.
Mass
89.99 kDa
Sequence
MAASALQQPSYLLANLKADWTNKPLHQRCHELCKIIDDYPAKELHAIFPWLVECVFGSLDGILTGWNLRFLQARSAEYSIAMEFLDPSGPMMKLVYKLQAEEYKYEFPISYLPGPIKSSIHAGVLPDCPLFHNKIQFPMSGLLFLNPFEYYMFNFASSLIAPKNYPQGQHGSSSDSAYFVLVDTYLKYFLPTEGNVPPSPFSDTRGTVASPAPRSTNVPYVGYGGHSTSLLKRHITHQSSVNADPAAQEIWRSETLLQVFVEMWLHHYSLEMYQKLQSPQVKEPFMPSEEHVLVVRLLVKHLHTFSSSLKPESISSSPSAHSHSSPLEELKRVVVQRFVQQKLYVFLQHCFGHWPLDASFRAVLETWLSYIQPWRYTGDKNNTQTDGPNRTVPDKWASFVQENLLLYTKLFQGFLNRAMRTDLVNAKNALMVFRVAKVFAQPSLSEMIQKGEQLFLEPEHAILQRHNRVFLTPSHGGSFLSARQPMGTDNVFKVKSHVYSLEGQDCQYNLMFGPDQRKNVLKLIQIIAQARQTAKRISDHSTEMAANNSFLSWFGVGSPDHNSTFTGGEMDEMGGEGVKKTHEFLDKALDYLCQIFRLNAGQLSQLISNVASVDNNGASKQLPDCIPSENGLVLTDLGRLQIINGLRRFEIEYQGDPELQPIRSYENAFLVRLLFQISSFINERLGEHMEVLCSRQDFLGSVGRHYLSSSSAVVEQRRKSPVTRQMRDRPQRARLSLRALASYRTLLTLLLLYMLFALLSFGLFSSTGLILIISFLYELLSNFFHEKLKTH