smc-5

Gene

smc-5

Protein

Structural maintenance of chromosomes protein 5

Organism

Caenorhabditis elegans

Length

1076 amino acids

Function

Core component of the smc-5/smc-6 complex (PubMed:20661436). Functions in DNA double strand break repair by promoting sister-chromatid homologous recombination during meiosis (PubMed:20661436, PubMed:27011106, PubMed:27010650, PubMed:24424777). Acts in a DNA repair pathway for removal of ionizing radiation- and ultraviolet (UV) radiation-induced DNA lesions that is distinct from classical nucleotide excision repair and the translesion synthesis pathway (PubMed:20661436, PubMed:24424777). Also involved in the recovery of stalled replication forks (PubMed:24424777).

Similarity

Belongs to the SMC family. SMC5 subfamily.

Mass

123.461 kDa

Sequence

MASQDSDEALPANYKDYPDGSLLRVVFHNFLTYEHTSFLPTASLNMILGHNGSGKSSIICGICLACGGSPKSLGRSERIVEYIRHGCTEGYVEIAIADKQKGPQVVRLTIRVGEQPKYRLNDSATTQSEIADLRKHYNIQIDNPCAFLAQDKVKSFSEQSSIELLRNTEKAASADLDQQHIDLMKQREDSTSIEDKCTTSENAIKRLEDEIGKIMPLVENYRKKLALQSKLRLLEKKMKIMEFEKFDREYKAELQNMDGAMIEYREVEKSIAECEKHRKNLEDRIKKDRSQISQMQRSCNEILAKVQEKGDKKLMEDMMQRAKAKLESAKKAADQHEKDVEKARKMIDQARARLQEAVDTLNGYEEFQSEMKSLEQKYSTAERDSRQEEDAIQKKSYEMRQLENKKRDEEQNSQLNRQDRYRVLQNFSSDASKAYRWYQQNRSQFKGDVYMPIMDMVLKTPEAAKALENSVGVRDRTMFVCCYKEDELLINGKQHSWRINTSVVPAEKIYSEDIDAQLPSELSRLGFKYLVSNCFDAPAPLKQFLCNVSGLNRIPFGGSDVEKKIAEVSQAIEQTRYSVFLTANIRCQNSKSRYANNTLQSQSATREANTWRDQFFKVSPVAKRTDNSILEEIQKLKAEIDIRSEQLREKRGAIQKERDVLRQEQMQWKSKKQVHTKWKTELASEMAKLEALENEVVDISAIEEEYANVEKKAILETKKMLENSIRWHKEIIDKHRLIGIFELSESICKSRVNKSNSEAETHRSKLEDLKSVKDAAEDLLKTALNHKKAAASALMKECSLKTLDESKMSPAENKIYSSLVKMFEEADVPTDMNTLDQAITSEKTRLKLAEDSGEDGSIVHEQRLKVLDDDLVLEKTRQEKLIENRARIHDKLGDEINNWRKEVETMIEQINVNYVQFFDSLGCRGEVSLEVPENPLDIEKYGIMIMVCFRKGESMKRLDNKVQSGGERSVATMLYLLALQQLCPVPFRCIDEINQGMDPTNERKVFDIMVGMWNGTTGTLSKTQYFLLSPKLLHGLDMRENVNIVMVNSTLTNSHGKHYDTSAKIDATFAKMGISA

Protein

Structural maintenance of chromosomes protein 5: smc-5