Protein
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1B
Function
DNA helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity and is both required for DNA repair and heterochromatin organization. Promotes DNA end resection of double-strand breaks (DSBs) following DNA damage: probably acts by weakening histone DNA interactions in nucleosomes flanking DSBs. Required for the restoration of heterochromatin organization after replication (By similarity).
Similarity
Belongs to the SNF2/RAD54 helicase family.
Sequence
MRRKKGPASSSDHEEPPESDSVIPETPETKRPSGSSLSTAISDSDSDSDSEISGSSMMPVRKLRPRKRKAASSADEYSVSDEEEEIVVKTKRRPTHSRTTRSTSQQAQPAHQKASETVTDIAHPSPLKTSGMAAADSVQQRRRQQMCGSSQESDSRKGGRVSAADDSEEEGQRSKDQERMLRKLQRKFPHLNKNELRDVLQEHDWLIDDALETLRMFSDLVVESEDDSSQTSTPAKHTRRVAETRPQAQVTKLSSPPKPKPSRPLDGTRTSQRIAKQPILAKYTYVSSEEECSDSEASVVNGLLDSDSDQSEETLSKLKTEILCFFQSASVDELTLIAGCSLKKAQKITELRPFKTWKDLDDAMRRRNGLSAELLAGCREVLKEREVVKGLMSKCEEISVKLIQDVTQVMDKGPGSMTQPEILSSTFQLKPYQLIGLNWLVLLHQNKLSGILADEMGLGKTIQAISFLAHLYQEGNHGPHLITVPASTLDNWVRELNLWCPSFKVLVYYGSADDRKYMRYEILNQIVEYNIIVSTYNLAIGNSSDRSLFCKLKLEYAVFDEGHLLKNMNSLRYRHLMAINAKYRLLLTGTPLQNNLLELMSLLNFIMPNMFSSSTSQIAKMFSMKSSEEQSSFERDRITHAKLIMKPFILRRVKSEVLKQLPAKEEQVEFCAMSERQQELYSALLHKLKHSSNGEKRELTNVMMQLRKMSNHPLLHRQFYTTEKLKAMSKLMLKEPSHRDADPALIKEDMEVLSDFELHRLCQQYSALHEYQLNTDVLLDSGKLSLLTQLLNSLKEKGDRVVLFSQFTMMLDILEVFLRHHKHRYNRLDGSTPMSDRIGLIDQFNTDQDIFVFLLSTRAGGLGINLTSANVVILHDIDCNPYNDKQAEGRCHRVGQTKTVKVIKLISKDSIEDTMLRIGERKLKLEQEMTATQDGEEDTLPDDMTTLLKASLGL