Protein
L-amino acid dehydrogenase
Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Function
L-amino acid dehydrogenase with broad substrate specificity. Catalyzes the oxidative deamination of various L-amino acids, L-Arg and L-Cys being the best substrates in vitro. Likely functions mainly as an L-arginine dehydrogenase in vivo. Probably feeds electrons from L-arginine oxidation and also from the oxidation of other L-amino acids into the respiratory electron transport chain associated to the thylakoid membrane, and does not directly interact with molecular oxygen but donates electrons to the plastoquinone pool. Cannot use D-amino acids as substrates.
Similarity
Belongs to the flavin monoamine oxidase family.
Sequence
MVIRSGKTNLNPPCALMAPSSSCDCIIVGSGLSGLIAARNLSRVNYSVLVIEAQERLGGRMYGEYLPSGQWIDRGGQWVGPTQDRFLALLNEYNIERFPSPADGLKVLLFDGKRYEFDGFFQGVFQGEAPKISSDEWNDAMVAWEKFNTLAQSLDEQHPEATPENKKLDSQTFADWIKENTHTAFGHWYFSYMCRAVGFLGPAEPSQVSLLHILWGHKSASQGENPEAELLHGGAGQIPQKIAAELGNSILLGEPVIHIAQDDKGVEVTTTTGKYQGKFAIVATPPHLAGRITYSPPMPPLRQQLTQRVPMGTCCKLLISYDRPFWREKGLAGIGLGNTTWIELCADSSDPTTGVGVIASFVVGDRYGKWIAMGEAERRQGVLSDLALYFGEEALSPETYDEVDWPSEQWVGGGYAAFMPPGVWTSFGQALSAPVGRIHWAGTEIAPRWAGFFDGAIRTGEAAAKAIIGLL