SLC7A6

Y+L amino acid transporter 2

515 amino acids

Involved in the sodium-independent uptake of dibasic amino acids and sodium-dependent uptake of some neutral amino acids. Requires coexpression with SLC3A2/4F2hc to mediate the uptake of arginine, leucine and glutamine. Also acts as an arginine/glutamine exchanger, following an antiport mechanism for amino acid transport, influencing arginine release in exchange for extracellular amino acids. Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. Involved in the transport of L-arginine in monocytes. Reduces uptake of ornithine in retinal pigment epithelial (RPE) cells.

Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.

56.828 kDa

MEAREPGRPTPTYHLVPNTSQSQVEEDVSSPPQRSSETMQLKKEISLLNGVSLVVGNMIGSGIFVSPKGVLVHTASYGMSLIVWAIGGLFSVVGALCYAELGTTITKSGASYAYILEAFGGFIAFIRLWVSLLVVEPTGQAIIAITFANYIIQPSFPSCDPPYLACRLLAAACICLLTFVNCAYVKWGTRVQDTFTYAKVVALIAIIVMGLVKLCQGHSEHFQDAFEGSSWDMGNLSLALYSALFSYSGWDTLNFVTEEIKNPERNLPLAIGISMPIVTLIYILTNVAYYTVLNISDVLSSDAVAVTFADQTFGMFSWTIPIAVALSCFGGLNASIFASSRLFFVGSREGHLPDLLSMIHIERFTPIPALLFNCTMALIYLIVEDVFQLINYFSFSYWFFVGLSVVGQLYLRWKEPKRPRPLKLSVFFPIVFCICSVFLVIVPLFTDTINSLIGIGIALSGVPFYFMGVYLPESRRPLFIRNVLAAITRGTQQLCFCVLTELDVAEEKKDERKTD

Slc7a6

Y+L amino acid transporter 2

515 amino acids

Involved in the sodium-independent uptake of dibasic amino acids and sodium-dependent uptake of some neutral amino acids. Requires coexpression with SLC3A2/4F2hc to mediate the uptake of arginine, leucine and glutamine. Also acts as an arginine/glutamine exchanger, following an antiport mechanism for amino acid transport, influencing arginine release in exchange for extracellular amino acids. Plays a role in nitric oxide synthesis via transport of L-arginine. Involved in the transport of L-arginine in monocytes. Reduces uptake of ornithine in retinal pigment epithelial cells (By similarity).

Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.

56.771 kDa

MEAQELGSPTPTYHLLPKANQHTVKEDAGSPSQGSPETMQLKKEISLLNGVSLVVGNMIGSGIFVSPKGVLKYTASYGLSLIVWAIGGLFSVVGALCYAELGTTITKSGASYAYILEAFGGFIAFIRLWVSLLIVEPTSQAIIAITFANYIIKPSFPTCDPPYVACRLLAAACVCLLTFVNCAYVKWGTRVQDTFTYAKVLALIAIIIMGLVKLCQGHTEHFQDAFKGSSWNVGDLSLALYSALFSYSGWDTLNFVTEEIKNPERNLPLAIGISMPIVTLIYILTNVAYYTVLNIQDVHKSDAVAVTFADQTFGMFSWTIPIAVALSCFGGLNASIFASSRLFFVGSREGHLPNLLSMIHIERFTPVPALLFNCTMTLIYLVVKDVFLLINYFSFSYWFFVGLSVVGQLYLRWKEPDWPRPLKLSLFFPIVFCVCSLFLVAVPLFSDTINSLIGIGIALSGVPVYFLGVYLPESRRPLFIRNVLATVTRVTQKLCFCVLTELDVTEEKNVERKTD

slc7a6

Y+L amino acid transporter 2

514 amino acids

Involved in the sodium-independent uptake of dibasic amino acids and sodium-dependent uptake of some neutral amino acids.

Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.

56.654 kDa

MKETENQTVPLNSTSPGDTSHTSTSDSKDPQDTMQLKKEISLLNGVSLIVGNMIGSGIFVSPKGVLIYSASYGLSLILWSLGGIFSVIGALCYAELGTTIKKSGASYAYILEAFGDFVAFIRLWTSLLIIEPTSQAVIAITFANYLVQPVFPSCYPPYMASRLIAAACVCLITFINCAYVKWGTRVQDLFTYAKVIALIAIIITGIVKLSQGQTENFEDSFAGSSWDAGEISLGLYSALFSYSGWDTLNFVTEEIKNPERNLPLSIGISMPLVTIIYILTNVAYYTVLDFNAVVASEAVAVTFADMVYGVFSWTIPVAVALSCFGGLNSSILAASRLFFVGAREGHLPDMLCLIHQERFTPVPALLFNCVATLIYLAVKDVFQLINYYSFSYWFFVGLSIAGQIYLRIKKPELPRPVKLSLFYPIVFCLCTVFLVIVPLYSDTVNSLIGIGIALSGIPVYFMGIYLPESKRPPFISRVLAFLTRRTQMIFNCVLTEMDPIDEKKQNQTENRKVQ

slc7a6

Y+L amino acid transporter 2

510 amino acids

Involved in the sodium-independent uptake of dibasic amino acids and sodium-dependent uptake of some neutral amino acids.

Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.

56.001 kDa

MKETENQTVPLNSTSPEDTSNTSNMASEGTHETMQLKKEISLLNGVSLIVGNMIGSGIFVSPKGVLIYSASYGLSLILWALGGIFSVIGAPCYAELGTTIKKSGASYAYILEAFGGFVAFIRLWTSLLIIEPTSQAVIAITFANYLVQPVFPSCNPPYMASRLIAAACVCLITFINCAYVKWGTRVQDLFTYAKVIALIAIIITGIVKLSQGQTENFEDSFAGSSWDAGDISLGLYSALFSYSGWDTLNFVTEEIKNPERNLPLSIGISMPLVTIIYILTNVAYYTVLDFNAVVASEAVAVTFADLVYGVFSWTIPVAVALSCFGGLNSSILAASRLFFVGAREGHLPDMLCLIHRERFTPVPALLFNCAATLVYLAVKDVFQLINYYSFSYWFFVGLSIAGQIYLRYKRPELPRPVKLSLFYPIVFCLCTVFLVIVPLYSDTVNSLIGIGIALSGIPVYFMGIYLPESKRPPFISKILAFLTRWTQMIFSCVLTEMDPNDEKKEEAKSN

slc7a6

Y+L amino acid transporter 2

468 amino acids

Involved in the sodium-independent uptake of dibasic amino acids and sodium-dependent uptake of some neutral amino acids.

Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.

51.234 kDa

MQLKKEISLLNGVSLIVGNMIGSGIFVSPKGVLIYSASYGLSLVIWAIGGIFSVVGALCYAELGTTITKSGASYAYILESFGGFIAFIRLWTSLLIIEPTSQAVIAITFANYLVQPLFPTCEPPYSASRLIAAACICLLTFINSAYVKWGTRVQDVFTYAKVLALIVIIITGIVKLCQGFTINFEDSFQGSSRDPGGIALALYSALFSYSGWDTLNFVTEEIKNPERNLPLSIAISMPIVTIIYILTNVAYYAVLDMSAILASDAVAVTFADHTLGVMSWTIPIAVALSCYGGLNSSIIAASRLFFVGAREGHLPDALSMIHIERFTPVPALLFNCAMALIYLTVEDVFQLINYYSFSYWFFVGLSIAGQIYLRWKEPDRPRPLKLSLVYPIIFCLCVVFLVAVPLYSDTLNTLIGIAIALSGVPVYFLGIHLPESKRPPIITKLLSAITRFTQFTCFYVLTEMDTVD