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slc22a6-a

Gene
slc22a6-a
Protein
Solute carrier family 22 member 6-A
Organism
Xenopus laevis
Length
558 amino acids
Function
Involved in the renal elimination of endogenous and exogenous organic anions. Mediates the sodium-independent uptake of p-aminohippurate (PAH), 2,3-dimercapto-1-propanesulfonic acid (DMPS), cidofovir, adefovir, 9-(2-phosphonylmethoxyethyl) guanine (PMEG), 9-(2-phosphonylmethoxyethyl) diaminopurine (PMEDAP), ochratoxin (OTA), acyclovir (ACV), 3'-azido-3-'deoxythymidine (AZT), cimetidine (CMD), 2,4-dichloro-phenoxyacetate (2,4-D), hippurate (HA), indoleacetate (IA), indoxyl sulfate (IS) and 3-carboxy-4-methyl-5-propyl-2-furanpropionate (CMPF) and edaravone sulfate. PAH uptake is inhibited by p-chloromercuribenzenesulphonate (PCMBS), diethyl pyrocarbonate (DEPC), indomethacin, sulindac, diclofenac, carprofen, okadaic acid, benzothiazolylcysteine (BTC), S-chlorotrifluoroethylcysteine (CTFC), cysteine S-conjugates S-dichlorovinylcysteine (DCVC), furosemide, steviol, phorbol 12-myristate 13-acetate (PMA), calcium ionophore A23187, benzylpenicillin, bumetamide, losartan, probenecid, phenol red, urate, glutarate and alpha-ketoglutarate (By similarity).
Similarity
Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
Mass
62.453 kDa
Sequence
MSFAELLERTGGMGRFQITQVALMCFPILLMASHNLLQNFSAAIPDHKCKANDTWYQSNNTDRMGYVRLSAPLDADGQPDRCLEYVEVQWMIAGTNRTWANSSQLATRPCTEGWEYSKDEFNSTIITEWDLVCGHKNRRQLAQSVYMGGVLVGAIILGGLSDRYGRRALLIWSYFQMAVSGLCSAFSPNYLSYCIFRFLTGMALSGIGLNTTALIVEWVPTRVRTITGTLAGFSYTVGQLLLAGLAYAMRDWRWLQLCVSLPFFIFFLYSWWFPESARWLVLSGKTERAVKEMKKVAKLNGKEEEGEKITLESMRSDMIKELACAKSSYTVIDLIRTSTIRRISCALSLVWFSTSFAYYGLAMDLQNFNVSIYLIQVIFGAVDFPAKIFSTTAMIYVGRKFTQLMSLILGGVVILANSFVPHEMQTVRTGMAVFGKGCLAASFSCVFLYTTELYPTVIRQSGLGLCSTMARIGGIVAPLVKILGEYYPFLPLVIYGGAPIISGLCVFFLPETVNKPLPDTIEEVEKRIKAPKKENEMNEIVSLKKKEGMKENPVNDVL