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skr-1

Gene
skr-1
Protein
Skp1-related protein
Organism
Caenorhabditis elegans
Length
176 amino acids
Function
Probable essential component of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:17626846). Regulates cell proliferation during embryonic and larval development (PubMed:11864567, PubMed:11864566). Involved in synapse elimination in early synapse development (PubMed:17626846). May negatively regulate the apoptotic activity of cep-1 in response to genotoxic stress (PubMed:18340346). Plays a role in sex determination (PubMed:18718460).
Similarity
Belongs to the SKP1 family.
Mass
20.032 kDa
Sequence
MADQKKVSEAAKEREIKISSSDNEIFLVPRNVIRLSNTINTLLMDLGLDDEEGTNAEPIPVQNVTASILKKVISWCNHHHSDPISTEDSDNREKRTDDIGSWDVEFLKVDQGTLFELILAANYLDIKGLLDVTCKTVANMIKGKSPEEIRRTFNIKNDFTPEEEEQIRKENAWCED