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six1a

Gene
six1a
Protein
Homeobox protein six1a
Organism
Danio rerio
Length
283 amino acids
Function
Transcription factor that is involved in the regulation of cell proliferation, apoptosis and embryonic development. Depending on context, functions as transcriptional repressor or activator. Plays an important role in the development of the inner ear, where it promotes hair cell proliferation and inhibits proliferation of neural progenitor cells (By similarity). Required for normal myogenesis. Plays a role in the development of fast muscle fibers throughout the body, as well as the development of craniofacial muscles.
Similarity
Belongs to the SIX/Sine oculis homeobox family.
Mass
31.928 kDa
Sequence
MSILPSFGFTQEQVACVCEVLQQGGNLERLGRFLWSLPACDHLHKNESVLKAKAVVAFHRGNFRELYKILESYQFSTHNHPKMQQLWLKAHYVEAEKLRGRPLGAVGKYRVRRKFPLPRTIWDGEETSYCFKEKSRSVLREWYTHNPYPSPREKRELAEATGLTTTQVSNWFKNRRQRDRAAEAKERENGENNGVGGKQSQRSPLDGVKSLMSSSEDEFSPPQSPEHSSVLLLQGTMNNPAAPAYPMPGLGAPHPLHGMQGHPHQIQDSLLGSLTSSLVDLGS