sirA

Multidrug resistance protein sirA

1263 amino acids

Sirodesmin transporter that provides the dual role of sirodesmin export and self-protection (PubMed:15387811, PubMed:15707846). Provides also tolerance to gliotoxin (PubMed:15707846).

Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.

137.141 kDa

MAEPESEKPSSAQGGGLPSSDHPLNPILQRQIELPEIKINYFSLFRYATVKEYALLLISAFFAAVSGAMFPLLILFIGNLVQVLKDFNLGTIPQEQLSEQIRDIALYIVYLFLGQLVSVFIFTNGCLLVGEAITNAIREKYVRSLFRQNIAFFDTYGSGKITSQLTSSTATIQDAISHKIGLFVSACSCFVASYAIGFVKHWKLTFILTSTVVAITGVMIIMSGFMAKFGANSSGALAEASAKLEETFSGIRVVKALGLEKRLSDELDPQLLNIEFWGKRVRHVMGWMLAIMYGLIFLNYGLAIWQGYRFMQGGTEDVGAIITVLMCLNIGAFLFGNVGPHLQAMSLGAAAAQDIFAVIERESVTDGGAPPGSFEVEGNIEFRNVSHVYPSRPDTHVLQDFSMIFPAGKVTAIVGASGSGKSTIVSILERFYEPVSGQVFLDGHDITHLNVQWLRQQFGLVGQEPVLFNGSIFKNVAYGLKGTQYGQESREVTMKLVTEACRIANAHDFITALPHGYDQEVGIRGASLSGGQRQRIAIARAIVSGPKILLLDEATSALDVQSEEAVQLGLNMASSGRTTIVVAHSLSTIKLADNIIVMEKGRVAQQGTHAELEAQEGLYQTFVRRQQLKQATLEPPHARITPAVDTPASPQHRLSEKTGSIYGQGESEAADKSPSTKYSFVQLVKFVARFNKEDWRLMVTGIASAVISGAVWPAHSVFFAKAIVALSSPSPASLARGPNFWAAMYVMLAFVQIASQGVQGSAFAICAERLILRARRVAFKYLLRQDVEFFDDPLHSSGIMTSFVSSDVNALAGLSGVFLGTLFSATATVLGGLILSLAVGWKLTLVTMGTIPIIIVAGYVRLKLVGTLEKISRKVHEESAGRVCEEINAVRTVAASCLEDEMCEDYVRSLKSKEKTYLRATLWSSGWYALSEAVPLGCMSLGFWYGATLVMRTEYTTEQFFIVVTAVIFGASSAGLVFAFAPDFGKAGVSAERLQELVDRQPEVDTWSEEGDHIETTNGKVDVSNVVFYYNQRSKTPVLNSISLGAAPGQSIGLCGGSGSGKSTVASLLERFYNPSSGTVSLDEKDVRTININSYRAQFALVNQEPLLFSCSIRENLLYGSLGKDLTDSEIEEACKMAQVYDFVCSLPEGLDTSFGSNAVMLSGGQRQRLSIARAILRKPRVLILDEATSALDSTSERAVIEALTKTAEGRTTIMVAHRLSTIQGCDKIFYLRAGAVAEEGTHEELMAKRGSYYDSVNLQSLG

sirA

Dissimilatory sulfite reductase SirA

708 amino acids

Respiratory sulfite reductase that catalyzes the reduction of sulfite to sulfide in a single step, consuming six electrons in the process. Required for sulfite respiration under anaerobic growth conditions. Does not contribute to nitrite reduction.

Belongs to the multiheme cytochrome c family.

79.125 kDa

MKRWKTKTALGVLFCLGSAVSATTIASDAKSDGKVVPGVGNKQQTHYTQDILANPKVSENLMEKSRGVKTLQDYIVQEQELFDFLFENHPVFKYDAEGRLKGTYKVSDRGEEYLHGGDSVAYSKHSKEVNSTDGTAVRYSAYEDGQRPKALQYRLGAKSILDFPNKFVGPEKCGECHGPQYEKWRRSRHSKTIRFPGEHPEVDNDLKKPMYTTKDTSILPSGITPDAIYATVGTPRTKYGFIDAYLVRGTYHVKDGLLKDGTGTMVAGGNQFSRGWAEWLTPEMAAKINKAIPSFPLKMEDFGTSGSHQWGMSSYGAKYEKEFLFQPASSYCEMCHSFKFDFQTKEEFFAALGNPKELQKHTISKGITCEECHGAGGHLDGGIGGGMPSNCERCHQRFNFVEELAETPQGQEKLEYAFNVKMKSSCPSCGTEGSQMFASAHYDKGMRCSTCHDPHEVTDGDWKSGITKPKIIKECTDCHTAQAEIAKNTNTHSNQTCQSCHMPNMGSCENFTAIQFPDMAGFDNVRKSHMWKIDVDPLRKTLNPPEGKSRDATTKGWTVAKDENGYNYLDLMWTCARTSASDHDVTENKGCHSQFQSELEVGLHFEDQMEIYGEVQKWQKPVKDLFGQVLQGLQRIDKLLEVTQLPVDKKTEVLMLTDKAQDVIKLVEADGSWGAHGPRYTQKRLDAALTYVQQAQAIIDGNGYNAKM

sirA

Sporulation inhibitor of replication protein SirA

148 amino acids

Inhibits DNA replication in growing cells, thus reducing chromosome copy number and playing a significant role during the onset of sporulation.

18.142 kDa

MERHYYTYLIKEEFANHYFGRESVMFELFQDYHWTSLEKQQYEMTEKQIQYITQPIPILHMHQRLKMNLNKTDYRQLDYIYRIALPKAKGHATFMMKEHMIEIVASGDYEAETIFFEVLRKVSPCFLAMDFNSKRYGWLNPVKERNFV