Protein
NAD-dependent deacetylase sir2E
Organism
Dictyostelium discoideum
Function
NAD-dependent deacetylase, which plays an important role in the regulation of transcriptional repression (By similarity). May play a role in cell cycle. When overexpressed, the cell cycle is accelerated.
Similarity
Belongs to the sirtuin family.
Sequence
MTDDIVFENMVIDDTIVEEEDVEMKYYLKNKKEFEFLAKEMLSGKKILFITGAGLSINSGISAYRNTKTSVWSNFITEWGTRKKFEQDPAQFWNHFWLRTHEKQEYLDALPNSGHLAISNFVEYLGSNVITQNVDALHLKAKVPIEKLVEVHGRISLYKCITKGCRFEYDDTIDNIEIGDYSINGTTMKQGNLEITPPLCPECKKPILPQSLLFDENYSSHQFYNIEKAMDWIQEADIFIFIGTSFSVGITEEVICHAQSERKKMFNFNIFKETKISGLKSIVGKSEITLPLLERQLLYEAQKRNNGKKQIWYGNTIKRIVSENSMLLKEAMLKNDTKSSVKV