Protein
NAD-dependent protein deacetylase Sir2B
Organism
Plasmodium falciparum (isolate 3D7)
Function
Regulates the expression of the surface antigen-coding var genes central to the malaria pathogenesis. Cooperates with Sir2A to mediate silencing and mutual exclusive expression of only 1 of the 60 subtelomeric var genes at a time, coding for functionally different but epitopically variant versions of the erythrocyte membrane protein 1 (PfEMP1) molecule, to evade the detection by host immune surveillance.
Similarity
Belongs to the sirtuin family. Class IV subfamily.
Sequence
MSCMNYASRLSKNEYKGPLGEEEFFEDTEEEKKKVKELIEKIRSSEYIVVHSGAGISTSSGLQDFRGPTGIWTNEHLNELKNKKKRNHDFKDNKRKLKSNDINCKNTSDMCSPSFFHKEKKENTLNIVKRERYYNEDNVDMNACNERVVHPNHVYVNHEDDNNNNNNNNNNDNNLYNNVYNSVGSNDHTNKESILIKKENNSENVRKDIHDKVNTKNVKKIDVKETNNLDPENYVIFGKRKKKVIELHLALPSKTHIMINELINKNIIKFMITQNIDSLHHRCGKHFSKTAEIHGNIFTERCDFCGRRYLRDYLISTISFKPTGSLCFLCSFPPIGVCTDVLLDWNNSYEEFFHLNSIKHSQIADFHFCLGSSFYIVPASSYPSKKKYANANSYSCVINYQKSFLSKEVNLNIHSNVNNISDIIIKEFSLNPLSIRSARITIVRCPINTLDVICDKLISIHNIKMKHKSMRQHSIDYSQMGNKDEKYNNEKYVKRNMTECLYYNKEGECYEKRKYKLMEKKFFPNNQQNEFIPNRINIFEQKFHEHNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNSSSSIDSSCSINSNYHISKNINPDFSFVENQSNIYENYKEQTFILICPMIINIKTVRLESFHKVYIKLLDDIKGLWFIKTNFSCILEVELWYHSFILLKLDFNKSDPFIQLNAWNVNVAYTYGDDIDDFDYFKNDENIKKPFNLYKNKYISNMRREGHVNNLYTLDNEKVKSNTSNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNDNNNNNISDHNIYDDHNNNNNKNHNNYDKDNSNESYYCSEILNEHVHVGYNPNNYEPNCKVYILAYLDNLRTRNINNNVNNNNFSRFNLTQSCKLLYNIYCVLNKDNEQKKNSTIKETYDKLDYFIKNFDFNRDSCLYTNNFINMLIQNERHGNQSRYKFRERRKRLLNDYSSCSSDDDQSGKNIFIFYNLYMNQYKKKEDNEINDIYKKYDVHEKNIYDESKQYVHKVRVRTDLINHKSVYKILKNNYLVNINNMKLMEKKNNSEKLFLINDKDNNSLLSINNKENFNCIPSRQNNVKKNSEYMHEEENNKTNSNENIARLNNNDFIQVMETEKQKKYNSFDKYNSDRSSINDTFDEIKYNKNNDNNNDDNNYDDNKNDDDNNNDDNNNNDDNNNNDDNNNNDDNNNGYIYSPVLFINKKFKLGELVYKIPKYVKPQKIYTPYKKISRNKKYSNTLQKDRYEKWKMLYEELINNENKTYIIDSVLYKEISYLPYWILNYVNDLFECM