Protein
RNA polymerase sigma factor SigI
Organism
Bacillus subtilis (strain 168)
Function
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in regulation of cell wall metabolism in response to heat stress. Acts by regulating the expression of genes such as bcrC, mreBH and lytE (PubMed:18156261, PubMed:21541672, PubMed:23199363). Also plays a role in survival at low temperatures (PubMed:19114499).
Similarity
Belongs to the sigma-70 factor family. SigI subfamily.
Sequence
MKPVLSLLFKLGKKKQTLEKAVESIQKGNKDLQNELIQQYKPFIAKTVSSVCKRYIDEKDDEFSIGLIAFNEAIEKYSPEKGNSLLAFAELIIKRKVIDYIRKEARSAQNINIDLQEGDDQESSQSLIEAELSIDEYRRQIEQEQRREEILYFQKQLKDYGLSFKELLENSPKHTDARQNAIKVAMTLVEHEELAAILYTKKQLPVKQLEQLVSVSRKTIERNRKYIIAMCIIITGDYIYLKDYLKGVLHS