sidN

Nonribosomal peptide synthase sidN

4690 amino acids

Nonribosomal peptide synthase required for the biosynthetis of epichloenin A, an extracellular siderophore that plays a crucial role in endophyte-grass symbioses (PubMed:23658520). SidN assembles epichloenin A by activating and incorporating three trans-anhydromevalonylhydroxyornithine (trans-AMHO), 1 glutamine and 4 glycine moieties (PubMed:23658520). Trans-AMHO is produced from L-ornithine via 2 steps involving a L-ornithine N(5)-monooxygenase and an AHMO-N(5)-transacylase that have still to be identified (PubMed:23658520). The third adenylation domain (A3) of sidN incorporates the hydroxamate groups of the siderophore which forms an octahedral iron complex (PubMed:23658520). The other component amino acids are assembled by sidN adenylation domains A1 and A2 (PubMed:23658520).

Belongs to the NRP synthase family.

516.329 kDa

MDQVAVTRFPALHCFEGPKQRQSVGSNARHHTIRGNIDTQHQSQDETLRRFANFVSSLVGDDEISFDFIISPSNGGSDIAESGTAQAKKDPTQATSDYNGITLLRSTPFVESGHSEFGIIIRRQLRNNDSSLFTLEKSFVVAVDKSSYSVRICRDLVPRPLLQSISTSLCSYMGWTNPSQHSEEESNQELQLQTLNFQGQSVLNHPPLMTPPDFESQLCLPKRPQEYAKPLLHNAFLARVRENPGRIALDALSSTGRATYTYKSLDDLSSDLAEKILQIIGVDADHTDRNITVALSTSAELYIAWLGILKAGCVVSPVPTDCPSGLLQHMTGLTSSKVVLGSAETLEYFDRIIGDSSTFTFINVETIARQNYEHLLQRPPPLVNTSENDVAYILFTSGSTGKPKGVQITHHAAVCSIAANIAASPYSFESGPSSIRWFQMAAPTFDLSVLEIFVTFSIGGTICACDRTMMLTDAESVITQLEATITMTTPTLASLLRPSRIPKLREVWVCGEMLKREASELFARDRDPSVADGDTNLLNAYGPTEATITCTVDARVSLKHRGSLIGPPLPTCSNIILDSSEPPKAVPLGFAGELAIGGPQLSIGYLKSPEKTAAAFVDVEPYGKLYRTGDMARLIMGPDGTLQVEFLGRLSSDQIKILGRRVELGEIEAGLRNPLIAEVAAVALKPEVSGLPQVQLIAVVTCRTEKSDSDILAACQERAENVLQPHMRPSIYYVMDKLPRLASEKTDRKTLAKYCLSPEKSGLRRLRNGDVDGHREAGSSSIPMLQSVIEAVSSVAIVGSDKITSATTLLSLGIDSLRSVRLLQNFREIGIEGLQVTDILTCHNLGDLDTKAQQALNRSTPSLAKARNLQTLLIDFENRHKKQCLSALGFNEDNIVSFLPVTTSQAVALASFLLTADANGFQAVPGGKAFIQHTVYTVKPELNSQRIVESWTRVLSRYDIMRSVFVEVNDDLTPFAQCILSPDHEAAQIKPHFYSAKSDNECKDVIQAAQKAAEEKISLYEPPRRLSVVQSPTQTIIVFSQLHSVFDGGSETLLLEDIEREYFGQPSIERTGVLTAVERHFSENRAEAAQFWQAYMDGFLSPSFPCLRSTVPGPDENVCGGYSFMSDLSLESLTRQAAALQCSPLSILQAAWAQILFTYTGERDVAFGNTMSGRFTTELVNCSAPVLTIQSTRVNLNEENDKRNIDILLERTAQNTAALSYLHTPITGARYDTTIALQMYLNSGKGEALYERVCHPGMQNDLAVMIEVYPDRSGLLEFRLTYQTALLDDDAAYTMLANLARVTNHIMSYPNAKYMDPSVWTSLQGPGQLEQINGYHHLGQQLLHECVAEFAQKSPNAIALAFYDDLSVDHPKVQLTYADLEVKATRVAGFLMSQLPAKEGSKHVVPIFMEKCPELYITLLGILKAGAAWCPVDPSYPPARQIFLIEKTTAGICFTSKSTTSQLSSILPASFKSISVSDLLEGGSCSTSRTLKASESARLDNLSIQRSDIAYVIFTSGTTGTPKGVPISHESASLSIDSYIQRVNVDLDLRGCEVRFLQFANYTFDAFVCDVFTAWRLGGTLVSATRDILLGSFIALANKVGATHTSMTPTFASTLQPQDFETLRVATMGGEVLPQILADKWKSRMSLCNVYGPAETAINTTINRLSAASRSGNIGTALPAVNAYVMASGYPVMKHMLGELVISGPQLSPGYWDNVHSSNNRFRWNSTLQCRVYHTGDYVRQLADGSFDFVGRKDDLVKIRGMRVELTEISTVCSAGHESVVHSEVLLAKLPGSTQSSLICFVDCGLQKSSDVDNFCILKNEEAQLVAQAVKRHATAELPRHMVPDVFMPLNCLPRNQSSKVNRKRLLEVIGREWSMQPMSPVADEQVDPAWCIKHRPLLEKIQGVIKIMPTTLSRSTTLSELGVDSIGAIRLSSRLKNDGHDISAIQVLDSVTIEDLINHLSVKRQGTSNWKTLLSRYLDHWKPLVSRHLARDPAHFSLVPTTVFQDGMLVETLRDPMLYWASYSWRLPSTVDIARVRQAWQHVSKNHDILKVSFVPTAYFEQEETQSSGPSSMFIQLIDYNASMGWQEIVSDSGDWQQSIHALCANLQRTQHENNFSSPPWRVTILAQQDQRIMNLTIHHSLCDGEMLRSLMHDVAWAYSTAELPVKRCQVQEAVSRLAVRYSEPEGHKFWGDMLSPLVSQTSLGDATSNSPKAVVRKIRHRTTELQATRSTSKLTGLARRLGASSLSPLFRVTFGIMLTEYYEQQSVLFGEVRSERLLESQLVGAMAPLSATYPVPFRSSGNLKDMVHSQQILVMDSIRYGPPQPSDVRKILKKSRDEALYSAVYVLRQRSEDDGGSLAPWEEFKDIFEIFVDHEFALNVLEGADDTVTISLSVDETLMSSSAQAIFLQQLDALLIAFDKSAPEISLSGLNAHFPLDLLSIASSKVSAQYTSTVPPSHYIETWAKTHPEWKAVEVATGFLGSQKIVTEDWTYKKLNETANQVANLIIHASLHGRAIAVSLDRSLIAFAIIVGIMKSGNTYVPIEAGLPNDRKSFLLRDSRAAMAFVCDNNFDGVELPPETKVLDTKNQSFIENLSTQDTSDILNNYPENLDAYLLYTSGSTGAPKGVRVSRHNLSSFSDAWGKLIGNVAPKSLELGGVGKFLCLASRAFDVHIGEMFLAWRFGLCAVTGERLSMLDDLPRTFRELGVTHAGIVPSLLDQTGLVPEDAPHLVYLGVGGEKMTPRTQQIWSSSDRVALVNVYGPTEVTIGCSAGRILPDSDTRCIGHPLGDSVAHVLAPGSNEHVKKGMAGELVIEGSLVANGYLNRPDAKGFCDINGRKMYRTGDIVRMDADSSILFLGRKDEQVKVRGQRLELGEVSEVIRSLSPTDIDVVTLLLNHPGTSKQFLVSFVASSGAAVRGELRWINENYKEINNSLRQACEQTLPAYMVPDFIIPISFIPLRDTSAKTDAKALEHMFHTLSLGELFGESSSLVNKPTTAPSRDLTSIEKQILTVVKSVVGQDDKRDARPGSTLFQLGLDSIASVKLSFKLKKLGFSTTVARLLQNPTIEELGRMKNALKGSHHAEPSNSESITTRFEELEKETMNSLKDRETTHIESIRPCMPLQEVLVAHTMSHGSEADNAYVSHMIFELDPAVVVEHVKAAWAAVVKNTELLRTCFIDRENDIVQLVIKENHATPVWKHLSNGTNMLKEELLSCKKEIADDIVTNIDKSPPVRFTLASCDGADETNEMSLFMLSIHHALYDMVSIEMIFQDFEVAYTDSSLSRRPSTLPLLEHIAAQQQNESKAKSYWTTLFDGYDHRIEKISPRTAQTTARTLNASLTTLESLCSQTNMTLSALIQGVFAYVLARTLKRPDLIFGVVLSGRSIDVEGIDAMAAPCISTIPQRLNIGTDGETIAELITTVQDRLFKSMEYQYTSLRSLSRWLEISGPLFSSLFSFTKLSPPEDSGSSKSRILKPTEGEMFLDFELALECEADPGTDTVTLRTRSTMFDKMEELDALLEQMESLVTSFTRGENKAVDGDFGSMLHTRLLPPHGSLQEESDDWSVLEQQIRDVVVAFSGASPNEVKRTTPFIKYGIDSITTIRFSTLLRKNGFWVSGADVLRNPSVAKLATHIQTTSSFNGTAKDSDDEASESAGIGNWSKALLAGAVSTKVLDDVVAVYPLTPLQAGMISATVMMDPTLYAHHHPFRLPQGTSIDQVRSAWSRLVAKHDILRTSFHEINQPRPQLVGAVHQESILNWHEVATEDVQVAIDDLIKRTQFPSVSSFETPPVKATVIRSPEDMLLVVSLHHATYDGTSIRFIFEDLWAILRGNRVPERNPFYETAMKIHNMSSGSVGFWADSLSGYGGAAAIAEAEDIQNKMTSKTMLLAQDTSALEQWCTEKGITIQTICQLAVSKAVCAQTKSRDVVLGQVHAARLDINGADKVAGPMLNTVPLRLCIHDDSFTNHDYLRDLQAFQNKSLDHLHASLSDIQRLWRKENGRDGQLFEVLFIFRKGEDATEAPFWQPFEPEGSKESLPPSHYDLVIEVHQKSRGGLELEVHSRFADDTTSNLMSLLVESFESIRKHPDELAISSPGVLSKVPKPGLTRETGAVPTSPFDQSAIDQFLDPLRKVLSETTDTPVSSIDAQTSIFSIGVDSIVAIRVAGACRKAHIPLHTMEIMRNAKIGKLCEVAFAKSGQAAPNRSTTESNGVAPLLDQEVKKAAASKLGRAEAEIQEILPVLPGQEYHLACWLTSGKTLLEPVWVFKAENGLDAGRLRDTWISLVQKNDSLRTCFAQVKPTLAVQAILKPDCVDAAKSFTVQQVPENMTMEEYVKSEIHHLSLSPSSLYEPPVRIVLIQGGREGVSVLLRLHHALYDAWSMGILIDELSSLYCGTMQKPCPPLSVSHFAQFTQQKLRGKNEEQFWTETLGQCDPTILTPKADINTDSKSCNRAFVSFECVDVSMGALKSAARAFGITPQCLIQVAFGRMLSDVTESSSPVFGYYTAGRSAELEGIEALASPTLNMLPVAVPKDLVASQLAGTSLSILLQSFQDRTNSQSDYEQSRLRDVIKWAPNKGVSPLFNAHLNILWNDEILLKPQVSKDTLLRPWPLGVPSDYASPTPLSRGSSVDGLDTSFLPTNVLFADVGPSRETANLAIGIGCDPTLRDAQGLEEIARMFSGHLSRLVGSRDLV

sidN

Nonribosomal peptide synthase sidN

4690 amino acids

Nonribosomal peptide synthase required for the biosynthetis of epichloenin A, an extracellular siderophore that plays a crucial role in endophyte-grass symbioses (PubMed:23658520). SidN assembles epichloenin A by activating and incorporating three trans-anhydromevalonylhydroxyornithine (trans-AMHO), 1 glutamine and 4 glycine moieties (PubMed:23658520). Trans-AMHO is produced from L-ornithine via 2 steps involving a L-ornithine N(5)-monooxygenase and an AHMO-N(5)-transacylase that have still to be identified (PubMed:23658520). The third adenylation domain (A3) of sidN incorporates the hydroxamate groups of the siderophore which forms an octahedral iron complex (PubMed:23658520). The other component amino acids are assembled by sidN adenylation domains A1 and A2 (PubMed:23658520).

Belongs to the NRP synthase family.

516.466 kDa

MDQVAVTRFPALHCFEGPKQRQSVGSNARHHTIRGNIDTQHQSQDETLRRFANFVSSLVGDDEISFDFIISPSNGGSDIAESGTAQAKKDPTQATSDYNGITLLRSTPFVESGHSEFGIIIRRQLRNNDSSLFTLEKSFVVTVDKSSYSVRICRDLVPRPFLQSISTSLCSYMGWTNPSQHSEEESNQELQLQTLNFQGQSVLNHPPLMTPPDFESQLCLPKRPQEYAKPLLHNAFLARVRENPGRIALDALSSTGRATYTYKNLDDLSSDLAEKILQIIGVDADHTDRNITVALSTSAELYIAWLGILKAGCVVCPVPTDCPSELLQHMTGLTSSKVVLGSAETLEYFDRIIGDSSIFTFINVETIARQNCEHLLQRPPPLVNTSENDVAYILFTSGSTGKPKGVQITHHAAVCSIAANIAASPHSFESGPSSIRWFQMAAPTFDLSVLEIFVTFSIGGTICACDRTMMLTDAESVITQLEATITMTTPTLASLLRPSRIPKLREVWVCGEMLKREASELFARDRDPSVADGDTNLLNAYGPTEATITCTVDARVSLKHRGSLIGPPLPTCSNIILDSSEPPKAVPLGFAGELAIGGPQLSIGYLKSPEKTAAAFVDVESYGKLYRTGDMARLIMGPDGTLQVEFLGRLSSDQIKILGRRVELGEIEAGLRNPLIAEVAAVALKPEVSGLPQVQLIAVVTCRTEKSDSDVLAACQERAENVLQPHMRPSIYYVMDKLPRLASEKTDRKTLAKYCLSPEKSGLRRLRNGDVDGHREAGSSSIPMLQSVIEAVSSVAIVGSDKITSATTLLSLGIDSLRSVRLLQNFREIGIEGLQVTDILTCHNLGDLDTKAQQALNRSTPSLAKARNLQTLLIDFENRHKKQCLSALGFNEDNIVSFLPVTTSQAVALASFLLTADANGFQAAPGGKAFIQHTVYTVKPELNSQRIVESWTRVLSRYDIMRSVFVEVNDDLTPFAQCILSPDHEAAQIKPHFYSAKSDNECKDVIQAAQKAAEEKISLYEPPRRLSVVQSPTQTIIVFSQLHSVFDGGSETLLLEDIEREYFGQPSIERTGVLTAVERHFSENRAEAAQFWQAYMDGFLSPSFPCLRSTVPGPDENVCGGYSFMSDLSLESLTRQAAALQCSPLSILQAAWAQILFTYTGERDVAFGNTMSDRFTTELANCSAPVLTIQSTRVNLNEENDKRNIDILLERTAQNTAALSYLHTPITGARYDTTIALQMYLNSGKGEALYERVCHPGMHNDLAVMIEVYPDRSGLLEFRLTYQTALLDDDAAYTMLANLARVTNHIMSYPNAKYMDPSVWTSLQGPGQLEQINGYHHLGQQLLHECVAEFAQKSPNAIALAFYDDLSVDHPKVQLTYADLEVKATRVAGFLMSQLPAKEGSKHVVPIFMEKCPELYITLLGILKAGAAWCPVDPSYPPARQIFLIEKTTAGICFTSKSTTSQLSSILPASFKSISVSDLLEGGSCSTSRTLKASESARLDNLSIQRSDIAYVIFTSGTTGTPKGVPISHESASLSIDSYIQRVNVDLDLRGCEVRFLQFANYTFDAFVCDVFTAWRLGGTLVSATRDILLGSFIALANKVGATHTSMTPTFASTLQPQDFETLRVATMGGEVLPQILADKWKSRMSLCNVYGPAETAINTTINRLSAASRSGNIGTALPAVNAYVMASGYPVMKHMLGELVISGPQLSPGYWDNVHSSNNRFRWNSTLQCRVYHTGDYVRQLADGSFDFVGRKDDLVKIRGMRVELTEISTVCSAGHESVVHSEVLLAKLPGSTQSSLICFVDCGLQKSSDVDNFCILKNEEAQLVAQAVKRHATAELPRHMVPDVFMPLNCLPRNQSSKVNRKRLLEVVGREWSMQPMSPVADEQVDPAWCIKHRPLLEKIQGVIKIMPTTLSRSTTLSELGVDSIGAIRLSSRLKNDGHDISAIQVLDSVTIEDLINHLSVKRQGTSNWKTLLSRYLDHWKPLVSRHLARDPAHFSLVPTTVFQDGMLVETLRDPMLYWASYSWRLPSTVDIARVRQAWQHVSKNHDILKVSFVPTAYFEQEETQSSGPSSMFIQLIDYNASMDWQEIVSDSGDWQQSIHALCANLQRTQHENNFSSPPWRVTILAQQDQRIMNLTIHHSLCDGEMLRSLMHDVAWAYSTAELPVKRCQVQEAVSRLAVRYSEPEGHKFWGDMLSPLVSQTSLGDATSNSPKAVVRKIRHRTTELQATRSTSKLTGLARRLGASSLSPLFRVTFGIMLTEYYEQQSVLFGEVRSERLLESQLVGAMAPLSATYPVPFRSSGNLKDMVHSQQILVMDSIRYGPPQPSDVRKILKKSRDEALYSAVYVLRQRSEDDGGSLAPWEEFKDIFEIFVDHEFALNVLEGADDTVTISLSVDETLMSSSAQAIFLQQLDALLIAFDKSAPEISLSGLNAHFPLDLLSIASSKVSAQYTSTVPPSHYIETWAKTHPEWKAVEVATGFLGSQEIVTEDWTYKKLNETANQVANLIIYASLHGRAIAVSLDRSLIAFAIIVGIMKSGNTYVPIEAGLPNDRKSFLLRDSRAAMAFVCDNKLDGVELPPETKVLDTKNKSFIENLSTQDTSDILNNYPENLDAYLLYTSGSTGAPKGVRVSRHNLSSFSDAWGKLIGNVAPKSLELGGVGKFLCLASRAFDVHIGEMFLAWRFGLCAVTGERLSMLDDLPRTFRELGVTHAGIVPSLLDQTGLVPEDAPHLVYLGVGGEKMTPRTQQIWSSSDRVALVNVYGPTEVTIGCSAGRILPDSDTRCIGHPLGDSVAHVLAPGSNEHVKKGMAGELVIEGSLVANGYLNRPDAKGFCDINGRKMYRTGDIVRMDADSSILFLGRKDEQVKVRGQRLELGEVSEVIRSLSPTDIDVVTLLLNHPGTSKQFLVSFVASSGAAVRGELRWINENYKEINNSLRQACEQTLPAYMVPDFIIPISFIPLRDTSAKTDAKALEHMFHTLSLGELFGESSSLVNKPTTAPSRDLTSIEKQILTVVKSVVGQDDKRDARPGSTLFQLGLDSIASVKLSFKLKKLGFSTTVARLLQNPTIEELGRMKNALKESHDAEPSNSESITTRFEELEKKTMNSLKDRETTHIESIRPCMPLQEVLVAHTMSHGSEADNAYVSHMIFELDPAVVVEHVKAAWAAVVKNTELLRTCFIDRENDIVQLVIKENHATPVWKHLSNGTNMLKEELLSCKKEIADDIVTNIDKSPPVRFTLASCDGADETNEMSLFMLSIHHALYDMVSIEMIFQDFEVAYTDSSLPRRPSTLPLLEHIAAQQQNESKAKSYWTTLFDGYDHGIEKISPRTAQTTARTLNASLTTLESLCSQTNMTLSALIQGVFAYVLARTLKRPDLIFGVVLSGRSIDVEGIDAMAAPCISTIPQRLNIGTDGETIAELITTVQDRLFKSMEYQYTSLRSLSRWLEISGPLFSSLFSFTKLSPPEDSGSSKSRILKPTEGEMFLDFELALECEADPGTDTVTLRTRSTMFDKMEELDALLEQMESLVTSFTRGENKAVDGDFGSMLHTRLLPPHGSLQEESDDWSVLEQQIRDVVVAFSGALPNEVKRTTPFIKYGIDSITTIRFSTLLRKNGFWVSGADVLRNPSVAKLATHIQTTSSFNGTAKDSDNEASEPAGIGNWSKALLAGAVSTKVLDDVVAVYPLTPLQAGMISATVMMDPTLYAHHHPFRLPQGTSIDQVRSAWSRLVAKHDILRTSFHEINQPRPQLVGAVHQESILNWHEVATEDVQVAIDDLIKRTQFPSVSSFETPPVKATVIRSPEDMLLVVSLHHATYDGTSIRFIFEDLWAILRGNRVPERNPFYETAMKIHNMSSGSVGFWADSLSGYGGAAAIAEAEDIQNKMTSKTMLLAQDTSALEQWCTEKGVTIQTICQLAVSKAVCAQTKSRDVVLGQVHAARLDINGADKVAGPMLNTVPLRLCIYDDSFTNHDYLRDLQAFQNKSLDHLHASLSDIQRLWRKENGRDGQLFEVLFIFRKGEDATEAPFWQPFEPEGSKESLPPSHYDLVIEVHQKSRGGLELEVHSRFADDTTSNLMSLLVESFESIRKHPDELAISSPGVLSKVPKPGLTRETGAVPTSPFDQSAIDQFLDPLRKVLSETTDTPVSSIDAQTSIFSIGVDSIVAIRVAGACRKAHIPLHTMEIMRNAKIGKLCEVAFAKSGQAAPNRSTTESNGVAPLLDQEVKKAAASKLGRAEAEIQEILPVLPGQEYHLACWLTSGKTLLEPVWVFKAENGLDAGRLRDTWISLVQKNDSLRTCFAQVKPTLAVQAILKPDCVDAAKSFTVQQVPENMTMEEYVKSEIHHLSLSPSSLYEPPVRIVLIQGGREGVSVLLRLHHALYDAWSMGILIDELSSLYCGTMQKPCPPLSVSHFAQFTQQKLRGKNEEQFWTETLGQCDPTILTPKADINTDSKSCNRAFVSFECVDVSMGALKSAARAFGITPQCLIQVAFGRMLSDVTESSSPVFGYYTAGRSADLEGIEALASPTLNMLPVAVPKDLVASQLAGTSLSILLQSFQDRTNSQSDYEQSRLRDVIKWAPNKGVSPLFNAHLNILWNDEILLKPQVSKDTLLRPWPLGVPSDYASPTPLSRGSSVDGLDTSFLPTNVLFADVGPSRETANLAIGIGCDPTLRDAQGLEEIARMFSGHLSRLVGSRDLV

sidN

Nonribosomal peptide synthase sidN

1928 amino acids

Nonribosomal peptide synthase required for the biosynthetis of epichloenin A, an extracellular siderophore that plays a crucial role in endophyte-grass symbioses (PubMed:23658520, PubMed:19923209). SidN assembles epichloenin A by activating and incorporating three trans-anhydromevalonylhydroxyornithine (trans-AMHO), 1 glutamine and 4 glycine moieties (PubMed:23658520). Trans-AMHO is produced from L-ornithine via 2 steps involving a L-ornithine N(5)-monooxygenase and an AHMO-N(5)-transacylase that have still to be identified (PubMed:19923209). The third adenylation domain (A3) of sidN incorporates the hydroxamate groups of the siderophore which forms an octahedral iron complex (PubMed:19923209). The other component amino acids are assembled by sidN adenylation domains A1 and A2 (PubMed:23658520, PubMed:19923209).

Belongs to the NRP synthase family.

214.117 kDa

single

LVAQAVKRHATAELPRHMVPDVFMPLNCLPRNQSSKVNRKRLLEVVGREWSMQPMSPVADEQVDPAWCIKHRPLLEKIQGVIKIMPKTLSRSTTLSELGVDSIGAIRLSSRFKNDGHDISAIQVLDSVTIEDLNNHLSVKRQGTSNWKTLLSRYLDHWKPLVSRHLARDPAHFSLVPTTVFQDGMLVETLRDPMLYWASYSWRLPSTVDIARVRQAWQHVSKNHDILKVSFVPTAYFEQEETQSSGPSSMFIQLIDYNASMDWQEIVSDSGDWQQSIQAVCANLQRTQHENNFSSPPWRVTILAQQDQRIMNLTIHHSLCDGEMLRSLMHDVAWAYSTAELPVKRCQVQEAVSRLAVRYSEPEGHKFWGDMLSPLVSQTSLGDATSNSPKAVVRKIRHRTTELQATRSTSKLTGLARRLGASSLSPLFRVTFGIMLTEYYEQQSVLFGEVRSERLLESQLVGAMAPLSATYPVPFRSSGNIKDMVHSQQILVMDSIRYGPPQPSDVRKILKKSRDEALYSAVYVLRQRPEDDGGSLAPWEEFKDIFEIFVDHEFALNVLEGADDTVTISLSVDETLMSSSAQAIFLQQLDALLIAFDKSAPEISLSGLNAHFPLDLLSIASSKVSAQYTSTVPPSHYIETWAKTHPEWKAVEVATGFLGSQKIVTEDWTYKKLNETANQVANLIIHASLHGRAIAVSLDRSLIAFAIIVGIMKSGNTYVPIEAGLPNDRKSFLLRDSRAAMAFVCDNNFDGVELPPETKVLDTKNQSFIENLSTQDTSDILNNYPENLDAYLLYTSGSTGTPKGVRVSRHNLSSFSDAWGKLIGNVAPKSLELGGVGKFLCLASRAFDVHIGEMFLAWRFGLCAVTGERLSMLDDLPRTFRELGVTHAGIVPSLLDQTGLVPEDAPHLVYLGVGGEKMTPRTQQIWSSSDRVALVNVYGPTEVTIGCSAGRILPDSDTRCIGHPLGDSVAHVLAPGSNEHVKKGMAGELVIEGSLVANGYLNRPDAKGFCDINGRKMYRTGDIVRMDADSSILFLGRKDEQVKVRGQRLELGEVSEVIRSLSPTDIDVVTLLLNHPGTSKQFLVSFVASSGAAVRGELRWINENYKEINNSLRQACEQTLPAYMVPDFIIPISFIPLRDTSAKTDAKALEHMFHTLSLGELFGESSSLVNKPTTAPSRDLTSIEKQILTVVKSVVGQDDKRDTRPRSTLFQLGLDSIASVKLSFKLKKLGFSTTVARLLQNPTIEELGRMKNALKESHDAEPSNSESITTRFEELEKKTMNSLKDRETTHIESIRPCMPLQEVLVAHTMSHGSEADNAYVSHMIFELDPAVVVEHVKAAWAAVVKNTELLRTCFIDRENDIVQLVIKENHATPVWKHLSNGTNMLKEELLSCKKEIADDIVTNIDKSPPVRFTLASCDGADETNEMSLFMLSIHHALYDMVSIEMIFQDFEVAYTDSSLPRRPSTLPLLEHIAAQQQNESKAKSYWTTLFDGYDHRIEKISPRTAQTTARTLNASLTTLESLCSQTNMTLSALIQGVFAYVLARTLKRPDLIFGVVLSGRSIDVEGIDAMAAPCISTIPQRLNIGTDGETIAELITTVQDRLFKSMEYQYTSLRSLSRWLEISGPLFSSLFSFTKLSPPEDSGSSKSRILKPTEGEMFLDFELALECEADPGTDTVTLRTRSTMFDKMEELDALLEQMESLVTSFTRGENKAVDGDFGSMLHTRLLPPHGSLQEESDDWSVLEQQIRDVVVAFSGALPNEVKRTTPFIKYGIDSITTIRFSTLLRKNGFWVSGADVLRNPSVAKLATHIQTTSSFNGTAKDSDNEASEPAGIGNWSKALLAGAVSTKVLDDVVAVYPLTPLQAGMISATVMMDPTLYAHHHPFRLPQGTSIDQVRSAWSRLVAKHDILRTSFHEINQPRPQLVGAVHQ