Protein
Fusarinine C esterase sidJ
Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)
Function
Displays specific fusarinine C (FsC) esterase activity but does not hydrolyze triacetylfusarinine C (TAFC), which has the same core structure as fusarinine C (PubMed:24038704). Both extra- and intracellular siderophores have been shown to be crucial for the virulence (PubMed:24038704). Subsequent to chelation of iron and uptake, FsC and TAFC are hydrolyzed and the iron is transferred to the metabolism or to the intracellular siderophore ferricrocin (FC) for transport and storage of iron (PubMed:24038704).
Sequence
MYSKFWPKGGLPGILHHYTETLVTFEYTTTTTRKPHSLLFVGGLGDGLATTSYLADLAHALQPTEWSLFTLTLTSSYQSWGLGHLDRDTNEIAQCLKYIKEYKTEKFGGSASSGKIVLMGHSTGSQCVLHYLSRPNPHTHTPAFDPYLEHVERMPLDGAIMQAPVSDREAIQWVLAEGLGDRTPAEIRPVFEKLTSMAREAARDADAGTDVLLPLAMTSLVYPAHTPLSARRFLSLTSPESPESPSEDDLFSSDLSDEQLGKTFGMIREQGLLRGKLMVLFSGADQSVPAWVDKDTLLSRWRNATDHNGEAAIWDENSGIIPNASHALSNDDQAEPRNFLVNKVLGYLSALVKA