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shpI

Gene
shpI
Protein
Neutral metalloprotease ShpI
Organism
Staphylococcus hyicus
Length
438 amino acids
Function
Protease that has a low substrate specificity. Catalyzes the hydrolysis of glucagon, melittin and oxidized beta-insulin at various positions in vitro. Is not able to cleave elastin or the synthetic substrates FAGLA (a substrate for neutral proteinases) and FALGPA (a substrate for collagenase).
Similarity
Belongs to the peptidase M30 family.
Mass
49.693 kDa
Sequence
MINKKKLVTSLVTSSLLATFTLGSFADAHTYIINNEDINKNAQESSIGTLKQNNFKQSTIDSMKPRNLQSFQEDKVFKAPKEKTPITERARKSENALSNSKLNDVRSFTTVNMRTNENERTAAKLKYNGKNTNVWVADNYITDKQAKNIGEEFDNKIDPLVKEKFGEPSDVDHDGKVNILVYDIKDDFETTGSYTGGYFHPRDLYDVPHSNKAEVFYMDTYPSMGTDKNNLNEKKVYSTLAHEYQHMVNANQKLLKEQKEDGMDVWLDEAFAMASEHMYLQKPLDHRIEYYNNSTSIANGHSLIKWNHRGDVLSNYALSYLFSQYLSAQSDNGDKIFKEILQDPANTSEALENAIHKHVDPKMSLGEFMTNFRVALEKKEATGLHGFNGAPGLNSISPKPVRELPQTLAPQGSVMFETTSPIKVPKDKDEKVNYVKVK